<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11410

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSHTNRSGTLSNNDLLRAHRVASTASRLFALASPSPVNTPAAVPTPGVPTPGTVSVPTPGGRSSPSSLPLMNIPGSTTSTLHQTAAEVSAYVEYVAREREKERERLKEVQAQRNRVTSSSSVANSGASTSASSNSNFGLRSVPPISIPPSIPPPFTGAIMHSGTDAQLFYPSPPTNPPSVSAAGVAVSPTAYQGTALLPQIPQGLPSMHDASVASSRISPSVSGTTSEVNKIVEGIMDISTIEISHDTTQGPLPETDASGTDIDNGIVNTGLPLTNVSAPPLVTTERLSSAPMTAPEPIVRSAPATNSDPTSGWTYFGSEGADFDGLGMLGNVGMNGIDNLTGNGMTTDNVDMTLFGAGGGNTFNFENLDSFGGGMDWNMDSTFSFGSGLTPSTSTSDQVTKSSTGVHTGMYADTRSTNTSFSSFQSADVFSQPMPPPTAPAVTAPTQTNASGTQQLGGGPGSGLGIGMDFEADFTDDDFSFFDNKASNTVNPVEPTSDSLILSASAPPNAATSPDPLAFLNSDDSSSFFSSLGLAPPLPIGSAPTPGFYGYPSHPTPFSISHPTPGGPTGFTPLTVDVEVEVEMNPGLPSPPEETNHPFARAYEVQLEQGTETSPFRLSSVHTPPPTLTSYSPPAPSSPSKDKKFAPIPFAKSHSQADGKYRVAGGKFALLRNSGRWLHKKYRPAYFTLDAPRRARAASWTGIMQGESSNGCFGEQVDLSEKDSRINGPSQGRWCLPSPPVDSDTTDSSAGESDDDQPHTSLEPPPPPTSISDASPPPPGSTDISMSSSYTHKTSRPGWRPRYDRATDPRIGVVRRLTGSKQRSKKRLKRAGWSEIHTRPKWLKDWEDDTGRHIDVANTGQSQEDEAEDDEDEDGGTADEEQDTDGGTLEELDDTPDMKASRRSGGREWSRSATPLPAYLPPGPSLVSTCFHWVHLASMAVGDNVSQTSTIEGMIHDSAPTPIHLNRGVGTTHGAPTPVSPVALAGSSAASFPTPAPTWPQALTPSADIDFIPTEEEKAWSLETAVNCIAQECVENPFWADAWKSMDEFMAWSPPTPESTPKMTSSTQTSRPICSSGSTPSTSSCILTPLSPPLLSVAKSEAIIHIMPAALRFWDKLGLGPKSGKKDVTVFVLYEQGYPEAEQHDRLGKAKIWRDEQIGFWLRNACALYKVKRLGEMFLGKSSLCQKDGLVSFQFGTSFRRSLTSFIASLPAPRDSFVFFILVPLAVMNLASETLHHVSSTINKVLSQYSEVQAVFQLIPEPYVLNTVVHPSSLHDFRSESFVHSVYNRILIPTDRAMSRKFFTYGQREKRYFEVPAFTLAHSLSENKVSYSSSVDPALDVLDRHTFLHVGYRISLCGRWILAACIDQRGEAHAMGVWSTQPYTPTDKNKKNDDSGVDVPVISDEMYIVNKVWDFAMQLAEKANVEWRIVIAKSGNMSVIELDAWITHLYTALHSNVQAPMHVSLLNVEQSVPWIILPFPAPQSTGHSAPNSKNPTLFRSTPGSVKISSKNQFFVDTATTTYGLLQKDTLPISVPPTLNDIGLSTDLVINKPLSIDDDDYSLVDDYPLLPLSSSTLICIPDSSVLPQMVNIHLIYATKSEECAYPNITSDAADSPQNLLHDITNSFYSLSVLSTARRDIAGTSLPFHLSAVETMRKALSTRNGVDSIR
Length1670
PositionKinase
OrganismLentinula edodes (Shiitake mushroom) (Lentinus edodes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Omphalotaceae> Lentinula.
Aromaticity0.07
Grand average of hydropathy-0.359
Instability index51.66
Isoelectric point5.18
Molecular weight179279.67
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11410
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.79|      15|      15|     322|     336|       1
---------------------------------------------------------------------------
  322-  336 (30.05/23.12)	GA...D.FDGLGM.LGNVGM
  338-  354 (18.44/10.42)	GI...DnLTGNGMtTDNVDM
  361-  377 (20.30/12.46)	GGntfN.FENLDS.FGG.GM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     205.48|      36|      36|     716|     751|       3
---------------------------------------------------------------------------
   48-   78 (33.24/ 8.24)	GVP...TPGTVSV..PTPGGRSSP.SSlplmniPGST......
  544-  566 (32.13/ 7.70)	.............SAPTPGFYGYP.SH......PTPFSISHPT
  568-  598 (43.06/13.02)	GGPTGFTPLTVDVEVEVEMNPGLP.SP......PEETN.....
  716-  751 (52.75/17.74)	GEQVDLSEKDSRINGPSQGRWCLP.SP......PVDSDTTDSS
  976- 1008 (44.30/13.63)	GAPTPVSP....VALAGSSAASFPtPA......PTWPQALTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     183.77|      80|     140|     622|     705|       4
---------------------------------------------------------------------------
  622-  662 (49.01/14.91)	..........................................................................................................SVHTPPPTlTSY...SPPAP.......SSPSKDKKFAPIPFAKSHSQADGK
  663-  704 (43.32/17.24)	YRVAGGK...FALLRNSGrWLHKKYRPAY...FTLDAPRRARAASwTG.............................................................................................................
  763-  812 (47.19/11.90)	................................................imqgessngcfgeqvdlsekdsringpsqgrwclpsppvdsdttdssagesdddqphtSLEPPPPP.TSIsdaSPPPPgstdismSSSYTHKTSRPGWRPRYDRATDPR
  817-  862 (44.24/10.86)	RRLTGSKqrsKKRLKRAG.WSEIHTRPKWlkdWEDDTGRHIDVAN.TG.............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.11|      17|      44|     478|     497|       5
---------------------------------------------------------------------------
  478-  497 (27.77/23.84)	DDDFSFFdnkASNTVNPVEP
  525-  541 (32.34/18.62)	DDSSSFF...SSLGLAPPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.58|      10|      44|     179|     188|       6
---------------------------------------------------------------------------
  179-  188 (17.22/ 7.37)	PSVSAAGVAV
  221-  230 (16.35/ 6.59)	PSVSGTTSEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.38|      21|     139|     291|     319|       9
---------------------------------------------------------------------------
  142-  178 (24.31/13.17)	SVPpisippsIPPPftGAIMHSGtdaqlfyPSPPTNP
  291-  311 (38.58/11.92)	SAP.......MTAP..EPIVRSA.......PATNSDP
 1480- 1497 (30.49/ 9.16)	..P.......FPAP..QSTGHSA.......P.NSKNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.48|      30|     137|     238|     272|      10
---------------------------------------------------------------------------
  238-  267 (54.78/27.72)	MDISTIEISHDTTQGPLP...........ETDASG..TDIDNG
  381-  407 (38.60/15.41)	MD.ST..FSFGS..GLTP...........STSTSDqvTKSSTG
  421-  456 (30.09/10.84)	TSFSSFQ.SADVFSQPMPpptapavtaptQTNASG..TQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.89|      45|     288|     901|     954|      14
---------------------------------------------------------------------------
  908-  954 (81.74/56.32)	GREWSRSATPLPAYLP.PGPSLVstCFHWVHLASMAVGDNVSQ..TSTIE
 1198- 1245 (70.15/31.79)	GTSFRRSLTSFIASLPaPRDSFV..FFILVPLAVMNLASETLHhvSSTIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11410 with Med13 domain of Kingdom Fungi
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