<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11407

Description Pyruvate dehydrogenase
SequenceMGLTGLARWINAPPDGLLAIRKNIQENHNGFLKGPWNLAVKSFRSTLSQTPGIHLPLERTMFTLQMNDNVFVLLEDPLAPTRADVVQAIADKTAPPNFHPTHYRTTFLTLNPPGALEQLLAQLKARWVPVRQTSTNNAQRGQASGHQLLIEGQVFGIGSDWLVRAGIVTMTGGEMKGMLLEAEYLPLPGLNVGPAADGTSELLSNLLTSVLPNVPDAKTVAVTISEAQWEDVLWDREEDEKAQKEVAQAKERESNGENDDIFVYGLEDIPIKRRGDWTGNKQLELYASKEPKPMTLRQLVFFGRSMDEDRLVKSANYVRTELPVRIAHRLRDLQKLPYIVVTQEGIAKVYELYWSAFEKFRKYPPITNIKENEAFCEFLAGLLDEHAIVIPSLSLGMSLSSPYLAPDDLDSFMRRMLVSRISRRVLAQHHIALSENYAGKKKPWESAEPNVGIITTGLNVKASIEKCANLLRHQSLEAEDAGGNAEIPAEVVIEGDVDMRFSYIREHLEYIVFELLKNSIRATRLNQAGSVTLPPITATIAAGDNAVGIRISDQGGGLITVQNPVQNPSDLFSFSHIRNSARMEHSRLISLRTASSYRRGIWATVNEQVENWNRSPDPEKDAGVGRHARMGIGLPMSNIFATYFGGSLDLKSLDGYGTDAYVRLPKLGTNLEAVNF
Length676
PositionHead
OrganismLentinula edodes (Shiitake mushroom) (Lentinus edodes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Omphalotaceae> Lentinula.
Aromaticity0.07
Grand average of hydropathy-0.271
Instability index36.89
Isoelectric point6.03
Molecular weight75077.63
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
mitochondrial matrix	GO:0005759	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11407
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.70|      18|     190|      67|      84|       1
---------------------------------------------------------------------------
   67-   84 (32.98/24.78)	NDNVFVL.LEDPLAPTRAD
  258-  276 (29.72/21.55)	NDDIFVYgLEDIPIKRRGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.53|      29|     341|     293|     323|       2
---------------------------------------------------------------------------
  293-  323 (48.41/37.86)	PMTLRQLVFFGRSMDEDRL..VKSANYVRteLP
  635-  665 (49.12/32.00)	PMSNIFATYFGGSLDLKSLdgYGTDAYVR..LP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.61|      12|     344|      23|      34|       4
---------------------------------------------------------------------------
   23-   34 (23.77/15.33)	NIQENHN..GFLKG
  368-  381 (16.85/ 8.88)	NIKENEAfcEFLAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.19|      52|     167|     402|     453|       5
---------------------------------------------------------------------------
  402-  453 (93.74/64.99)	PYLAPDDLDSF..MR...RMLVSR.ISRRVLAQHHIALSENYAGKKKPW.ESAEP..NVGI
  564-  624 (72.45/48.51)	PVQNPSDLFSFshIRnsaRMEHSRlISLRTASSYRRGIWATVNEQVENWnRSPDPekDAGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.26|      31|     162|     335|     367|       9
---------------------------------------------------------------------------
  335-  367 (53.16/47.35)	KLPYIVVTQEGIakVYELYWSAFEKFR.......KYPPIT
  500-  537 (48.09/35.67)	RFSYIREHLEYI..VFELLKNSIRATRlnqagsvTLPPIT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11407 with Med20 domain of Kingdom Fungi
Unable to open file!