<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11406

Description Pyruvate dehydrogenase
SequenceMGLTGLARWINAPPDGLLAIRKNIQENHNGFLKGPWNLAVKSFRSTLSQTPGIHLPLERTMFTLQMNDNVFVLLEDPLAPTRADVVQAIADKTAPPNFHPTHYRTTFLTLNPPGALEQLLAQLKARWVPVRQTSTNNAQRGQASGHQLLIEGQVFGIGSDWLVRAGIVTMTGGEMKGMLLEAEYLPLPGLNVGPAADGTSELLSNLLTSVLPNVPDAKTVAVTISEAQWEDVLWDREEDEKAQKEVAQAKERESNGENDDIFVYGLEDIPIKRRGDWTGNKQLELYASKEPKPMTLRQLVFFGRSMDEDRLVKSANYVRTELPVRIAHRLRDLQKLPYIVVTQEGIAKVYELYWSAFEKYWKYPPITNIKENEAFCEFLAGLLDEHAIVIPSLSLGMSLSSPYLAPDDLDSFMRRMLVSRISRRVLAQHHIALSENYAGKKKPWESAEPNVGIITTGLNVKASIEKCANLLRHQSLEAEDAGGNAEIPAEVVIEGDVDMRFSYIREHLEYIVFELLKNSIRATRLNQAGSVTLPPITATIAAGDNAVGIRISDQGGGLITVQNPVQNPSDLFSFSHIRNSARMEHSRLISLRTASSYRRGIWATVNEQVENWNRSPDPEKDAGVGRHARMGIGLPMSNIFATYFGGSLDLKSLDGYGTDAYVRLPKLGTNLEAVNF
Length676
PositionHead
OrganismLentinula edodes (Shiitake mushroom) (Lentinus edodes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Omphalotaceae> Lentinula.
Aromaticity0.08
Grand average of hydropathy-0.272
Instability index36.74
Isoelectric point5.95
Molecular weight75123.65
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
mitochondrial matrix	GO:0005759	IEA:UniProtKB-SubCell

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11406
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.70|      18|     190|      67|      84|       1
---------------------------------------------------------------------------
   67-   84 (32.98/19.17)	NDNVFVL.LEDPLAPTRAD
  258-  276 (29.72/16.65)	NDDIFVYgLEDIPIKRRGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.32|      32|      76|     479|     511|       2
---------------------------------------------------------------------------
  479-  511 (51.73/38.74)	EDAGGNAEIPAEVVIEGDVdMRFSYIR.....EHLEYI
  553-  589 (51.60/33.58)	DQGGGLITVQNPVQNPSDL.FSFSHIRnsarmEHSRLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11406 with Med20 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) FVYGLE
262
267