<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11382

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMWTNVFRIGGLHHISWFQFLPHESDLNPLPDKSVKVEHKDAATLLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDDKIKLWLFLPGHHSSVVETAQSAVSRLRVVASGLWLAPGDSEDVAAALSQALRNCIERALLGLSYMRFGDVFSKYHPSQTEDFFRRGRPTIEFIFSATEEAIYVHVIISSKHIRALSRGDMDGVLNSAYHNSRYILPVIVSPHGMRGGLSGCCPDDLVKQVYFSSGKFRTSNGFIGLPYHVSEGSTCYLRGQNCYVEVTLGYPRSRSDKASQSSSSSVRNLSKNHIAESMAVGRGDHKGSSDYLSVCEKTFIYPVEAVLVPVLQTFARSSLKRFWLQNWIGPSLPGSSFFVHCAGNINSMKGSWIETNGIRTQRGYNSSSNSNSSSISSISSSSSDSDYKMTGESGDLEADADSLTCKQSGLSSNDQLENDGLKLGSKRPRTGITESYGHGGAVSNAPVQDAYKSDFGAMEISNSAITGVTNDESGWDWDDDDRGMGMDIEALLSEFGDFGDFFENDVLPFGEPPGTAELQTLMFSVPECGDVGSSPVGVMDVSDQMLLPVGYPSFESFNLPLPTVTEDLSKYQEVTNSALSSGPVNNTPASSTGEFDHLIKSEALMTFAPEYGAVETPKSEFSSSIYRSPYLPKSRNLESSNSSAKNYIYCATPHSPPDFDEKDEQAGKSMNSKILKHDASAILQSKKCYTHLEGAKEKYDKRLITHDDSNATNEGVASSLFSNFNSTSAIKSVLRNNSEGSFGSDQVSHSMKTVPATQVECIMFQASMCRIRHILVSSSNSVSVGLSRLTGSSVLNQLPGEQSIMTGDISGRFEVKKKESIPVRIAGDFDGGMLDGHLNAPVGVWRSVGVPKLPKPSSSPSFEVSPSLPNNSFSEESMLSYGKRQPLQELLDGMELLVQQATSFVDIALDADCGDGAYGWLALQEHWRRGFPCGPSMVHAGCGGTLASCHSLDIAGVELVDPLAADIHPSSVISLLQSEIKTALKSAFGILDGPLSVTDWCKGRSQLIDTGTTGDGSSAESSISECRDSTSTITLSVGEPISPSQSSAGVSSCLKNGIKVEETCQRRSNQEISSSESEQQLGCRLRPTIFVNPSPAILVGYQDDWLKTSASSLQLWEKAPLEPYALPKPISYHVICPDIDPLTCAAADFFQQLGTVYETCKLGTHSPQSLGNQMEIDSGKWSASGFLLLDCPQSMKIESSNASLVGSISDYFLSLSNGWDLTSYLRSLSKALKGLKIGPCLSTHPKEGISGPCMVIYVVCPFPEPIAVLQTVIESSVALGSIIHPLDKERRSVFHSQVGKALSCCAAADEASVSNVLVLSGFSVPKLVLQIVTVDAVFRVTSPALNELVILKETAFTVYNKARRISRGSSNDVIHSSSLSNRSHSVLSQLNSIPGMWKDPVARMTGPSFSREGEIDSSLRPGAWENSNWQTRTGVLSCDPNRNGEYFLQEETRYMFEPLFILAEPGSLDQAVSPVLYGNLATESSKPLPDDNSGGFMQSAGSADTGSSTRLDGSEPDGFGSGPQKTLPSLHCCYGWTEDWRWLVCIWTDARGEFLDSHIIPFGGISSRQDTKGLQCLFVQVLQQGCQILQTCSSPDTGAAKPRDFVISRIGNFFELEYLEWQKAIYTVGGSEIKRWPLQRRSVPDGIAPSSNGSSLQQQEMSLIQERTLPSSPSPLYSPHSKASGFMKGSLGQPNTRKQLLGGHTVVDNSRGLLQWVQSISFVAISIDHSLHLVYQADLPFPGGTQGGSSVGPPGYIEGFTPVKSLGSTAASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGFAIPLSTGFAVSKAVPSMRKDYRNNLKDEWPSVLSVSLIDYYGNNISQEKIIRGIMKQGGRTLSSEARDFEIETHVVLESLVAELHALSWMTVSPAYLERRTALPFHCDTVLRLRRLLHFADKELYCQPDKTR
Length1975
PositionKinase
OrganismCephalotus follicularis (Albany pitcher plant)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Oxalidales> Cephalotaceae> Cephalotus.
Aromaticity0.08
Grand average of hydropathy-0.241
Instability index53.16
Isoelectric point5.61
Molecular weight214529.91
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11382
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.39|      35|      57|       2|      58|       1
---------------------------------------------------------------------------
    2-   42 (57.22/69.83)	WTNVFrIGglhhiSW..FQFLPHESDLNP....LP.DKSVKVEHKDAA
   62-  103 (53.18/22.68)	WTNSF.VG.....PWdpSQGLHNPDDKIKlwlfLPgHHSSVVETAQSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.28|      38|      62|    1003|    1040|       2
---------------------------------------------------------------------------
 1003- 1040 (64.65/39.17)	SVISLLQSEIKTALKSAFGI...LDGPLSVTDWCKGRS.QLI
 1063- 1104 (54.64/31.89)	STITLSVGEPISPSQSSAGVsscLKNGIKVEETCQRRSnQEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      23.60|       8|      79|     481|     500|       3
---------------------------------------------------------------------------
  472-  479 (14.56/15.30)	GA..VSNAPV
  488-  497 ( 9.05/ 7.71)	GAmeISNSAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.23|      47|      79|    1596|    1644|       4
---------------------------------------------------------------------------
 1596- 1644 (75.45/48.37)	GISSRQDTKGLQCLFVQVLQQgcQILQTCSSP.DTGAAKPRDFVISRIGN
 1678- 1725 (76.79/42.52)	GIAPSSNGSSLQQQEMSLIQE..RTLPSSPSPlYSPHSKASGFMKGSLGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.54|      36|      62|    1268|    1304|       5
---------------------------------------------------------------------------
 1268- 1304 (62.88/56.14)	KIGPCLSTHPKEGISGPCMVIyVVCPFPEPIAVLQTV
 1329- 1364 (58.66/45.47)	QVGKALSCCAAADEASVSNVL.VLSGFSVPKLVLQIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.06|      32|      52|     504|     541|       8
---------------------------------------------------------------------------
  504-  541 (46.98/51.23)	ESGwDWDDDDRGMgMDI..EALLS.EFGDFGDFfendVLPF
  559-  593 (52.09/32.76)	ECG.DVGSSPVGV.MDVsdQMLLPvGYPSFESF....NLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     285.76|      86|     816|     306|     442|       9
---------------------------------------------------------------------------
  234-  302 (76.72/45.69)	PddlVKQVYFSSG..KFRTSNgFIG..LP...YHV.SEGSTCYLRGQncYVEvTLGYPRSRS.DKASQSSSSSVRNLS.......................
  341-  434 (138.47/124.98)	P...VLQTFARSSlkRFWLQN.WIGpsLPgssFFVhCAGNINSMKGS..WIE.TNGIRTQRGYNSSSNSNSSSISSISSSSSDSDYKMTGESGDLEADADS
 1399- 1449 (70.57/18.85)	............................................RGS......SNDVIHSSSLSNRSHSVLSQLNSIPGMWKDPVARMTGPSFSREGEIDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.30|      43|     932|     950|    1000|      12
---------------------------------------------------------------------------
  943-  996 (64.60/68.65)	ADCG...........dgaYGWlalQEHWRRgFPCgpsmVHAGCGGTLASCHSLDIAGVELVDPLA
 1526- 1547 (23.82/ 7.20)	...........................................GGFMQSAGSADTGSSTRLDGSE
 1548- 1590 (40.88/23.87)	PDGFgsgpqktlpslhccYGW...TEDWRW.LVC....IWTDARGEFLDSH..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.72|      34|     536|     641|     687|      13
---------------------------------------------------------------------------
  644-  677 (59.70/40.55)	GAVETPKSEFSSSIYRSPYLPK.SRNLESSNSSAK
  881-  915 (58.02/17.12)	GVPKLPKPSSSPSFEVSPSLPNnSFSEESMLSYGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.24|      19|     536|    1190|    1228|      14
---------------------------------------------------------------------------
  436-  454 (34.66/ 8.89)	TCK...QSGLSSNDQLENDGLK
 1191- 1212 (31.57/42.53)	TCKlgtHSPQSLGNQMEIDSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      15|      31|     183|     197|      19
---------------------------------------------------------------------------
  183-  197 (26.77/14.44)	YV.HVIISSKHIR.ALS
  214-  230 (20.51/ 9.37)	YIlPVIVSPHGMRgGLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11382 with Med13 domain of Kingdom Viridiplantae
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