<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11373

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQETVEFSALVSRTAEESFLTLKGLVENSKSSELTDTDKKISLLKYLVKTQQRVLRLNVLAKWCQQVPLIQYCQQLASTLSSHDACFTQAADSLYFMHEGLQQARAPIYDVPSATEILLSGTYQRLPKCIEDMGIQSTLTEDQQKPALKKLDTLVRSKLLEVPLPKEISEVRVSDGTALLRVEGEFQVLVTLGYRGHLSLWRILHLELLVGEKSGLVKIEESQRHILGDDLERRMAAAEDPFITLHSVLHELCVALVMDTVIRQVQALRQGRWKDVIRFELISDGSGTSTQLNQDGESDSIGFRTPGSKIIYWLDHDKSSGTSDSASCPFIKIEPGPDLQIKCIHSTFVIDSVTGKESEFFLDQSCIDVENLLLRAIHCNRYTRLLEIQKDLAKNVQICRAIGDVLLQSQMNRSDVDNKMKHSKSEAREYQGQEVLRVRAYGSSFFTLGINIRNGRFVLQSSPNILHPSALLECEEALNQGSMTAAEVFISLRRKSILHLFASIGRFLGLAVYEQGFAAVKIPKNLSNGSSMLLMGFPECGGSYFLMMQLDKDFKPLFELLETQPDPSGKARSLNELDHVMRIKKIDIGQMQILEDELNLSILDRGKLLSFLPTAVVSSQSSEHGLLPEFNFEGSMHIGGGPTSSFSSVVDEVFELEKGAPAPTLFVQNISSPFNMSPASHVGSIPINVHSVKSGTPSPRWERGMQVSQINNVVKVPNGGNHYNGSVYLSNNLKSPGHSSSFNSLSSGPGRIKKLSASKSDQDLTSLRSPHSVEIGPVDEDQLRLLNDTSKDAVSGSRLSRLLSPPRTTGPRVPASIAKPNGPRSSPNGPLAGSFRGTVSSPLASTPVSQAAEAAICNSTSLDNVLKHDKNPRKRTLSDILSSIPSLQGVEANARLIKKWKFSEPAHSHQPSSESVIPTEMISNTEGYSYGNLIAEANKGNAPSSVYVSALLHVVRHCSLCTKHARLTSQMEALDIAYVEEVGLRSASSNIWFPLPFARGDSWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNITPWGTGVRIANTSNLDSHIRYDQEGVVLSYQTVEPDSIKKLVADIRRLSNARMFALGMRKLLGVRADEKLEESSGNSDVKTLVGGRAAVEAADKLSEQMRRAFKIEAVGLMSLWFSFGSGSLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTTGPLHALAAATRPARAGPVPGAPAVAAAVIASIPKQSGYLPSQGTLPSSTPSSIQATSSPVGNPIASTATGSLGNHGFHGAAMLAASGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPEGGPFVGGSLPCPQFRPFIMEHVAQELNGLDANFTGGQQTVGLANANNPSSVPQLSTSNGNRVNLPHSAAMTRTANQVAGLNRVGSALTGSSNLAVVNSGLPIRRSPGTGAPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQNSSSAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGVAQAQGGDVTPAQKPCIELCLENHTGINGGENSENSYTAKSNIHYDRPHNSVDFSLTVVLDPAHIPHINPAGGAAWLPYCVSVRLRYSFGENFSLSFLGMEGSHGGRSCWSRVDDWEKCKQRVARTVELNGSSTGDITQGRLKVVADSVQRTLHMCLQGLRDGTGGVTATSGAT
Length1814
PositionTail
OrganismCephalotus follicularis (Albany pitcher plant)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Oxalidales> Cephalotaceae> Cephalotus.
Aromaticity0.06
Grand average of hydropathy-0.169
Instability index45.40
Isoelectric point7.44
Molecular weight197255.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11373
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     502.76|     186|     291|     622|     837|       1
---------------------------------------------------------------------------
  623-  837 (269.80/227.80)	SQSSEHGLLPEFNFEGSMHIGGGPTS.SFSSVVDEVFELeKGAPAPTLFVQNISspFNMSPASHvgsIPinvhSVKSGTPSPRWERGMQVSqINNVVKVPNGGNhYNGSVYLSNNLKSPGHSS..............................................................................................................................................................................................sfnslSSGPGRIKKLSAsksdqDLTSLRSPHSVEIGPvdeDQLRLLNDTSKDAVSGSRLSRLLSPPR.TTGPrVPASIAKPNGPRSspnGPLAG
  853-  963 (147.15/75.73)	SQAAEAAICNSTSLDNVLKHDKNPRKrTLSDILSSIPSL.QGVEANARLIKKWK..FSEPAHSH...QP....SSESVIPTEMISNTEGYS.YGNLIAEANKGN.APSSVYVSALLHVVRHCS............................................................................................................................................................................................................................................................................................
 1159- 1235 (85.81/40.16)	...........................................................................................................................lctkharltsqmealdiayveevglrsassniwfplpfargdswqhiclrlgrpgsmywdvkindqhfrdlwelqkgsnitpwgtgvriantsnldshirydqegvvlsyqtvepdsikklvadirrlsnarmfalgmrkllgvradekleessgnsdvktlvggraaveaadklseqmrrafkieavglmslwfSFGSGSLARFVV.....EWESGKEGCTMHVSP...DQLWPHTKFLEDFINGAEVASLLDCIRlTTGP.LHALAAATRPARA...GPVPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     452.74|     154|     220|      19|     185|       2
---------------------------------------------------------------------------
   19-  185 (229.06/190.12)	AEESFLTLKGLVENSKSSELTDT.DKKISLLKYlvKTQQRVLRLNVLAKWCQQvpliqyCQQLASTLSSHDACF.TQAADSLYFM.HE...GL.QQARAPIYDVPSATEILLSGTYQRLpkCIEDM.GIQSTLTEDQQKPALKKLdtLVR.......SKLLEV..PLPKEISEVRvSDGTALLR
  242-  412 (223.68/151.04)	AEDPFITLHSVLHELCVALVMDTvIRQVQALRQ..GRWKDVIRFELISDGSGT......STQLNQDGESDSIGFrTPGSKIIYWLdHDkssGTsDSASCPFIKIEPGPDLQIKCIHSTF..VIDSVtGKESEFFLDQSCIDVENL..LLRaihcnryTRLLEIqkDLAKNVQICR.AIGDVLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.66|      17|      19|    1415|    1432|       3
---------------------------------------------------------------------------
 1265- 1279 (21.08/ 8.97)	..PSSIQATSSPV...G.NPI
 1403- 1419 (30.25/16.39)	NNPSSVPQLSTSN...G.NRV
 1420- 1440 (21.32/ 9.16)	NLPHSAAMTRTANqvaGlNRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.82|      17|     255|    1457|    1490|       4
---------------------------------------------------------------------------
 1473- 1490 (28.51/42.51)	GElNTAIIGLGDDGGYGG
 1730- 1746 (33.31/ 9.28)	GE.NFSLSFLGMEGSHGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.54|      33|     255|    1342|    1396|       5
---------------------------------------------------------------------------
 1349- 1385 (54.66/64.35)	WLQPATPPEGGPFVGGSLPCPQFrpFIMEHVAqeLNG
 1637- 1669 (60.88/22.75)	WKKGVAQAQGGDVTPAQKPCIEL..CLENHTG..ING
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.24|      19|     291|     202|     220|       6
---------------------------------------------------------------------------
  202-  220 (34.14/18.52)	LSLWR..ILHLELLVGEKSGL
  494-  514 (29.10/14.75)	ISLRRksILHLFASIGRFLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.32|      13|     159|     981|     997|      10
---------------------------------------------------------------------------
  981-  997 (20.58/22.45)	AY.VEEVGLRSassnIWF
 1145- 1158 (21.74/12.08)	AFkIEAVGLMS....LWF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11373 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HSSSFNSLSSGPGRIKKLSASKSDQDLTSLRSPHSVEIGPVDEDQLRLLNDTSK
2) QQTVGLANANNPSSVPQLSTSNGNRVNLPHSA
3) VSGSRLSRLLSPPRTTGPRVPASIAKPNGPRSSPNGPLAGSFRGTVSSPLA
742
1394
798
795
1425
848










Molecular Recognition Features






MoRF SequenceStartStop




1) RLIKKWK
899
905