<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11316

Description Mediator of RNA polymerase II transcription subunit
SequenceMDQSQRTVAATPSSSRSYQFHPARAAIIDLFNLYLGRGSRQKPDESLRDPPNKSQKRVHAPNRDLPPRNEQFLLDFELLQSQFNDPEQLRTITESVLISLVVQCSNHAPRAEFLLFALRTLCRISYINWDTFLPSLLSSVSAAEASLSQGVQAAAATAGSSATSSQSVVPVSVNPTSLLPSAHGIGSPSASEVKSVENGQQIARAGQIVRENAMRNSQRIRAAAVNSLRQLSCKIILIGVESSLKPVTHAEIFQYMMNWLVNWDRRDLGTEDSVGKSWRSEKTLAEWLRSCLDVIWLLVEEGESRIPFYELLRSGLQFIENIPDDEALFTLIMEIHRRRDAMAMHMLMLDQHLHCPSFGTHRIVSQITANVPPEAVPHLRHSPITYPSVLGEPLYGEDLAMSIPKGSLDWERAVRCIRHAIRTTPSPDWWKRVLVVAPCYRPSTQAGPIPGAVFTSDMICEAIIDRIVELLKLTNSDANCWQEWLVFSDIFFFLIKSGCTDFVDFIDKLVLRLNGVDNHILRTNHVTWLLAQIIRVELVMTALNSDAKKVETTRKILSFHREDRNSDPNNPQSVLLDFVSSCQNLRIWSLSTTTRAYLNNEQLLKGKQIDEWWRSKGERMMDYMNMDDRSIGMFWVVSYTMAQPACETVINWLSSAGMAELPGLQPNDRVMMTQEVTPLPMSLLSGFSMNLCLKLALQMEEALFVSQVVPSIAMVETYTRLLLISPHSMFRSHFSQLAQRNASLLSKPGVTLLVLEILNYRLLPLYRYQGKSKTLMYDVTKIISALKGKRGDHRIFRLAENLCMNLILSLRDFFSVKREGKGPTEFTETLNRITIMTLAITIKTRGIADPDHMVYLQTMLEQILATSQHTWSEKTMRHFPSLLRETLKGRVDKRGLSIQAWQQAETTVINQCTQLLSPSAEPAYVSTYLSHSFPQHRQYLCAGACLLMQGHAENINSTNLARVLREVSPEEVTANIYTLVDVLLHHVHVDLQQGQSLEAVLDKAGANLAFFFWTHEMLPLDIFLLALIDRDDDPHALIIAMSLLKTPDLLLRIKNYCQNRGSPEHWLVTQVFKRNELQKALGNHLSWKDRYPTFFDDIAARLLPVIPLVLYRLIENNAMEQADNLLLAHSHFLAYHPLRFTFVRDILAYFYGHLPGKLVLRMLKVLDLSKIPFSESFPQYISPTGAPVCPPLDYFASLLLNLVNNVIPPLSSSSNCSSRSGSMADILNSSARPPHGKTPGTSQPGPANASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPVSAAQIVSSLVQIIVNIQSTLIQSGNGFHGAANGVGQGSVLPTSPSGGSTDSMSASRSTCLIPGINTASFVSRSGYTCQQLSCLLIQACGLLLAQLPPDFHVQLYLEAARVTRETWWLKDGKRSQGELDSAVGYALMDPTWAAQDNTSTAIGNIVALLHAFFSNLPQEWLDGTNAIITNLRPVTSVAMLRVVFRIMGPLLPRLASTHTLFNKTLMLLLSALVDVFGKTAQTTAPVEASQIADLIDFLHHIIHYEGQGGAVQTSSKPRPDILALIGRAAETLRPDVQHLLAHLKTNPNSSIYAAAHQQNTAKTNTS
Length1596
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.07
Grand average of hydropathy-0.045
Instability index43.45
Isoelectric point7.17
Molecular weight178083.88
Publications
PubMed=11130712
PubMed=27862469

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11316
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     560.27|     188|     322|    1037|    1239|       1
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 1037- 1239 (277.04/213.59)	LIIAMSLLKT...PDllLRIKNYCQ.NRGSPEHWLVTQVfKRN..ELQKALGNHLSwkDryPTFF..DDIAARLLPVIPLvLYRLIENNAMEQAD..NLLLAH.SHFLAYHPLRFTFvRdILAYFYGHLPGKLVLrMLKVLDLSKIPFSESFPQyISPTGAPVcpPLDYFASlLLNLVNNVIPPLSSSSNCSSRSGSMADILNSSARPPHGKTP
 1366- 1564 (283.24/167.19)	LIQACGLLLAqlpPD..FHVQLYLEaARVTRETWWLKDG.KRSqgELDSAVGYALM..D..PTWAaqDNTSTAIGNIVAL.LHAFFSNLPQEWLDgtNAIITNlRPVTSVAMLRVVF.R.IMGPLLPRLASTHTL.FNKTLMLLLSALVDVFGK.TAQTTAPV..EASQIAD.LIDFLHHIIHYEGQGGAVQTSSKPRPDILALIGRAAETLRP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.85|      72|     544|     131|     206|       2
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  131-  206 (102.79/72.29)	TFLP.SLLSSVSaAEASLSQGVQAAAATAGSSATssQSVVPVSVNPTSLLPSAHGIGSPSASEVKSvENGQQIARAG
  677-  749 (118.05/69.28)	TPLPmSLLSGFS.MNLCLKLALQMEEALFVSQVV..PSIAMVETYTRLLLISPHSMFRSHFSQLAQ.RNASLLSKPG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.57|      23|     181|     296|     331|       3
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  296-  322 (36.65/27.43)	WLLVeegeSRIPFYELLRSG.LQFIENI
  484-  506 (35.55/15.63)	WLVF....SDI.FFFLIKSGcTDFVDFI
  528-  544 (21.36/ 6.58)	WLL.....AQIIRVELVMTA.LN.....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.63|      98|     132|     761|     864|       5
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  761-  864 (153.38/121.20)	RLLPLYRYQGKSKTLMYDVTKIIS.....ALKGKRGDHRIFRLAENLCMNLILSLRDffsvKREGKGPTEFTETLNRITIMTLAITIKTrgIADP..DHM.VYLQ..TMLEQIL
  894- 1001 (145.25/98.76)	RGLSIQAWQQAETTVINQCTQLLSpsaepAYVSTYLSHSFPQHRQYLCAGACLLMQG....HAENINSTNLARVLREVSPEEVTANIYT..LVDVllHHVhVDLQqgQSLEAVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.37|      28|     458|      94|     128|       6
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   94-  128 (38.27/45.18)	ESVLISLVVQCSNhapraeFLLFALRTLCRiSYIN
  572-  599 (50.10/34.62)	QSVLLDFVSSCQN......LRIWSLSTTTR.AYLN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11316 with Med23 domain of Kingdom Viridiplantae
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