<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11313

Description Mediator of RNA polymerase II transcription subunit 15a-like protein
SequenceMDNNNWRPSLPNGEPAMDTGDWRTQLPPDSRQKIVNKIMETLKKHLPFSGPEGINELRRIAARFEEKIFSGALNQTDYLRKISMKMLTMETKSQNAAGSSAAIPAANNGTSIDSIPTNQGQLLPGSLSTNQSQAPQPLLSQTMQNNTASGMTGSTALPSSMPPVSSITNNNTTSVVNQNANMQNVAGMLQDSSGQHGLSSNMFSGPQRQMLGRPHAMSSQQQQQPYLYQQQLQQQLLKQNFQSGNVPNPNSLLPSHIQQQQQNVLQPNQLHSSQQPGVPTSATQPSTVNSAPLQGLHTNQQSSPQLSSQQTTQSMLRQHQSSMLRQHPQSQQASGIHQQQSSLPQQSISPLQQQPTQLMRQQAANSSGIQQKQMMGQHVVGDMQQQHQQRLLNQQNNVMNIQQQQSQQQPLQQPQQQQKQQPPAQQQLMSQQNSLQATHQNPLGTQSNVAGLQQPQQQMLNSQVGNSSLQNNQHSVHMLSQPTVGLQRTHQAGHGLYSSQGQQSQNQPSQQQMMPQLQSHHQQLGLQQQPNLLQQDVQQRLQASGQVTGSLLPPQNVVDQQRQLYQSQRTLPEMPSSSLDSTAQTESANGGDWQEEVYQKIKSMKETYLPDLNEIYQRVAAKLQQDSMPQQQRSDQLEKLRQFKTMLERMIQFLSVSKSNIMPALKDKVAYYEKQIIGFLNMHRPRKPVQQGQLPQSQMQPMQQPQSQTVQDQSHDNQTNPQMQSMSMQGAGPRAQQSSMTNMQSNVLSSRPGVSAPQQNIPSSIPASSLESGQGNTLNNGQQVAMGSMQQNTSQLVNNSSASAQSGLSTLQSNVNQPQLSSSLLQHQHLKQQQDQQMQLKQQFQQRQMQQQQLQARQQQQQQQLQARQQAAQLQQMNDMNDLTSRQGMNVSRGMFQQHSMQGQRANYPLQQLKPGAVSSPQLLQGASPQMSQHLSPQVDQKNTVNKMGTPLQPANSPFVVPSPSSTPLAPSPMQVDSEKPGSSSLSMGNIARQQATGMQGVVQSLAIGTPGISASPLLQEFTSPDGNILNSSTITSGKPSATELPIERLIRAVKSISPQALSSAVSDIGSVVSMVDRIAGSAPGNGSRASVGEDLVAMTKCRLQARNFMTQEGMMATKKMKRHTTAMPLSVASLGGSVGDNYKQFAGSETSDLESTATSDGKKARTETEHALLEEIKEINQRLIDTVVEISDDEDAADPSEVAISSIGCEGTTVRFSFIAVSLSPALKAHLSSTQMSPIQPLRLLVPCSYPNGSPSLLDKLPVETRYKQILQSQVNRTIDFPYRVEQTSTIQLKSSQESSTRNPLLETALSSYRNTVWFLEQQRKRGPVVQSYGKVQHIAKKFVTADVAQRHSQDMGRLCSGSDL
Length1366
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.03
Grand average of hydropathy-0.789
Instability index70.93
Isoelectric point9.49
Molecular weight150232.21
Publications
PubMed=11130712
PubMed=27862469

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11313
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|    1000.38|     109|     110|     690|     798|       3
---------------------------------------------------------------------------
  140-  289 (82.26/15.21)	SQT....MQ.N.NTASG...M..............TGST.............ALPS.....SMppvssiTN.....NNTT.SVV......NQ.....NAN.M..QN.V......AGML....QDSS...G....QHGLSSNMFSGPQRqmlgrphAMSSQQQQQPylyqqqlqqQ.LLKqnfqsgnvpnpnsllpshiQQQ...QqnvLQPNQ........LH......SSQ....Q...PgvptsatQ..PSTVN
  290-  406 (84.98/15.99)	SAPlqglHT.NqQSSPQ...LS.SQ......QTTQSMLR.............QHQS.....SM...............LR.QHPqsqqasGIhqqqsSLP.Q..QS.IsplqqqPTQLmrqqAANS.........SGIQQKQMMGQHV........VGDMQQQHQ.........QrLLN...................QQN...........N........VM......NIQ....Q...Q.......Q..S....
  424-  518 (105.73/21.97)	AQ........Q.QL..........M......SQQNSLQA.............THQN.....PL.......G..TQSNV.....A......GL.....QQP.Q..QQmL......NSQV....GNSS...L....QNNQ.HSVHMLSQP.......TVG..LQRTH.........Q..AG................hglYSS...Q...GQQSQ........NQ......PSQ....QqmmP.......Q.....LQ
  519-  625 (97.60/19.63)	..S....HH.Q.QLGLQ...QQpNL......LQQDVQQR.............LQASgqvtgSL......LP..PQ.NVVD.QQR......QL.....YQS.Q..RT.L......PE.M....PSSS...L....DSTAQTESANG............GDWQEEVY.........Q.KIK.................smKET...Y...LPDLN.........E......IYQ....R...V.......A..AKLQQ
  626-  711 (107.23/22.41)	DSM....PQ.Q.QRSDQ...LE.KL.............R..............QFK.....TM......LE..RMIQFLSvSKS.....................N.I......MPAL....K................DKVAYYEKQ.......IIGFLNMHRP.........R.KPV...................QQG...Q...LPQSQ........MQ......PMQ....Q...P.......Q..SQTVQ
  712-  826 (172.64/41.26)	DQS....HD.N.QTNPQ...MQ.SM......SMQGAGPR.............AQQS.....SM......TN..MQSNVLS.SRP......GV.....SAP.Q..QN.I......PSSI....PASS...L....ESGQGNTLNNGQQV.......AMGSMQQNTS.........Q.LVN...................NSS...A...SAQSG........LS......TLQsnvnQ...P.......QlsSSLLQ
  827-  918 (91.02/17.73)	HQ.....HL.K.Q..QQ...DQ.QM......QLK...................QQF.....QQ......RQ..MQQQQLQ.ARQ.............QQQ.Q..QQ.L......QARQ....QAAQ...L...............QQ.........MNDMNDLTS........rQ.GMN..................vSRG...M...FQQHS........MQgqranyPLQ....Q...L.......K..PGAV.
  919-  976 (59.28/ 8.59)	.............SSPQ...L...........LQGASPQ..................................M.SQHLS...P......QV.....D...Q..KN.T......VNKM....................GTPL..................QPANS.........P.FVV..................pSPS...S...TPLAP.........S......PMQ......................V.
  977- 1060 (70.22/11.74)	..........D.SEKPG...SS.SL......SM.GNIAR.............QQAT.....GM......QG..VVQSLAI.GTP......GI.....S.........................ASP...LlqefTSPDGNILNSS.TI.......TSG......................................kpSAT...E...LPIER........L........IR....A...V.......K..SISPQ
 1061- 1189 (70.64/11.86)	ALS....SA.V.SDIGS...VV.SMvdriagSAPGNGSR.............ASVG.edlvAM......TKcrLQARNFM.TQE......GM.....MAT.KkmKR.H......TTAM....PLSV...A....SLG.GSVGDNYKQF.......A.GS...ETS.........D.LES................tatSDG...K...KARTEtehalleeIK......EIN....Q...R.......L..IDTVV
 1190- 1309 (58.77/ 8.44)	EIS....DDeD.AADPSevaIS.SI......GCEGTTVRfsfiavslspalkAHLS.....S.......TQ..M.SPI....................QPlR..LL.V......PCSY....PNGSpslL....DKLPVET..RYKQI...........LQ...S.........Q..VN..........rtidfpyrvEQTstiQ...LKSSQ........ES......STR....N...P.......L..LET..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.47|      15|      19|       1|      19|       4
---------------------------------------------------------------------------
    5-   19 (30.81/23.54)	NWRPSLPNG......EPAMDT
   21-   41 (23.65/ 6.73)	DWRTQLPPDsrqkivNKIMET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.50|      17|      20|      48|      64|       5
---------------------------------------------------------------------------
   48-   64 (30.21/20.56)	FSGP.EGINELRRIAARF
   69-   86 (26.30/16.88)	FSGAlNQTDYLRKISMKM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11313 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKQNFQSGNVPNPNSLLPSHIQQQQQNVLQPNQLHSSQQPGVPTSATQPSTVNSAPLQGLHTNQQSSPQLSSQQTTQSMLRQHQSSMLRQHPQSQQASGIHQQQSSLPQQSISPLQQQPTQLMRQQAANSSGIQQKQMMGQHVVGDMQQQHQQRLLNQQNNVMNIQQQQSQQQPLQQPQQQQKQQPPAQQQLMSQQNSLQATHQNPLGTQSNVAGLQQPQQQMLNSQVGNSSLQNNQHSVHMLSQPTVGLQRTHQAGHGLYSSQGQQSQNQPSQQQMMPQLQSHHQQLGLQQQPNLLQQDVQQR
2) MDNNNWRPSLPNGEPAMDTGDWRTQLPPDSRQKIVNKIMETL
3) MHRPRKPVQQGQLPQSQMQPMQQPQSQTVQDQSHDNQTNPQMQSMSMQGAGPRAQQSSMTNMQSNVLSSRPGVSAPQQNIPSSIPASSLESGQGNTLNNGQQVAMGSMQQNTSQLVNNSSASAQSGLSTLQSNVNQPQLSSSLLQHQHLKQQQDQQMQLKQQFQQRQMQQQQLQARQQQQQQQLQARQQAAQLQQMNDMNDLTSRQGMNVSRGMFQQHSMQGQRANYPLQQLKPGAVSSPQLLQGASPQMSQHLSPQVDQKNTVNKMGTPLQPANSPFVVPSPSSTPLAPSPMQVDSEKPGSSSLSMGNIARQQ
4) QASGQVTGSLLPPQNVVDQQRQLYQSQRTLPEMPSSSLDSTAQTESANGGDWQEE
5) SMKMLTMETKSQNAAGSSAAIPAANNGTSIDSIPTNQGQLLPGSLSTNQSQAPQPLLSQTMQNNTASGMTGSTALPSSMPPVSSITNNNTTSVVNQNANMQNVAGMLQDSSGQHGLSSNMFSGPQRQMLGRPHAMSSQQQQQPYLYQQQLQQ
237
1
682
542
83
540
42
995
596
234










Molecular Recognition Features






MoRF SequenceStartStop




NANANA