<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11312

Description Mediator of RNA polymerase II transcription subunit 15a-like protein
SequenceMNFVDVIKFAYFEFLDSRSENLMDNNNWRPSLPNGEPAMDTGDWRTQLPPDSRQKIVNKIMETLKKHLPFSGPEGINELRRIAARFEEKIFSGALNQTDYLRKISMKMLTMETKSQNAAGSSAAIPAANNGTSIDSIPTNQGQLLPGSLSTNQSQAPQPLLSQTMQNNTASGMTGSTALPSSMPPVSSITNNNTTSVVNQNANMQNVAGMLQDSSGQHGLSSNMFSGPQRQMLGRPHAMSSQQQQQPYLYQQQLQQQLLKQNFQSGNVPNPNSLLPSHIQQQQQNVLQPNQLHSSQQPGVPTSATQPSTVNSAPLQGLHTNQQSSPQLSSQQTTQSMLRQHQSSMLRQHPQSQQASGIHQQQSSLPQQSISPLQQQPTQLMRQQAANSSGIQQKQMMGQHVVGDMQQQHQQRLLNQQNNVMNIQQQQSQQQPLQQPQQQQKQQPPAQQQLMSQQNSLQATHQNPLGTQSNVAGLQQPQQQMLNSQVGNSSLQNNQHSVHMLSQPTVGLQRTHQAGHGLYSSQGQQSQNQPSQQQMMPQLQSHHQQLGLQQQPNLLQQDVQQRLQASGQVTGSLLPPQNVVDQQRQLYQSQRTLPEMPSSSLDSTAQTESANGGDWQEEVYQKIKSMKETYLPDLNEIYQRVAAKLQQDSMPQQQRSDQLEKLRQFKTMLERMIQFLSVSKSNIMPALKDKVAYYEKQIIGFLNMHRPRKPVQQGQLPQSQMQPMQQPQSQTVQDQSHDNQTNPQMQSMSMQGAGPRAQQSSMTNMQSNVLSSRPGVSAPQQNIPSSIPASSLESGQGNTLNNGQQVAMGSMQQNTSQLVNNSSASAQSGLSTLQSNVNQPQLSSSLLQHQHLKQQQDQQMQLKQQFQQRQMQQQQLQARQQQQQQQLQARQQAAQLQQMNDMNDLTSRQGMNVSRGMFQQHSMQGQRANYPLQQLKPGAVSSPQLLQGASPQMSQHLSPQVDQKNTVNKMGTPLQPANSPFVVPSPSSTPLAPSPMQVDSEKPGSSSLSMGNIARQQATGMQGVVQSLAIGTPGISASPLLQEFTSPDGNILNSSTITSGKPSATELPIERLIRAVKSISPQALSSAVSDIGSVVSMVDRIAGSAPGNGSRASVGEDLVAMTKCRLQARNFMTQEGMMATKKMKRHTTAMPLSVASLGGSVGDNYKQFAGSETSDLESTATSDGKKARTETEHALLEEIKEINQRLIDTVVEISDDEDAADPSEVAISSIGCEGTTVRFSFIAVSLSPALKAHLSSTQMSPIQPLRLLVPCSYPNGSPSLLDKLPVETSKENEDLSSKAMARFNILLRSLSQPMSLKDIAKTWDACARAVICEYAQQFGGGTFSSKYGTWEKYVAAS
Length1357
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.03
Grand average of hydropathy-0.753
Instability index71.04
Isoelectric point9.16
Molecular weight149010.93
Publications
PubMed=11130712
PubMed=27862469

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions
[Q15648<-->P03372: ESR1]	NbExp=3	EBI-394459,EBI-78473












Repeat regions





Repeats

>MDP11312
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     992.07|     109|     110|     712|     820|       3
---------------------------------------------------------------------------
  105-  181 (65.78/11.82)	..................................................................SM....KMLTM....ETKSQNA..AGSSA.......AIPAANNGTS.......idS.IPT...................NQG.....Q...LLPG..................S........LS......TNQ....S...Q.......A..P.QPLLSQT....MQN.N.TASGM..............TGSTALPS
  182-  343 (89.43/19.32)	SMppvssiTN.....NNTT.SVV......NQ.....NA.........NM..QNV......AG....ML....QDSSG....QHGLSSNMFSGPQRqmlgrphAMSSQQQQQPylyqqqlqqQ.LLKqnfqsgnvpnpnsllpshiQQQ.....QqnvLQPN..................Q........LH......SSQ....Q...PgvptsatQ..P.STVNSAPlqglHTNqQ.SSPQLS.SQ......QTTQSMLRQHQS
  344-  479 (74.62/14.62)	SM...............LR.QHPqsqqasGIhqqqsSL.........PQ..QSIsplqqqPT....QLmrqqAANS......SGIQQKQMMGQHV........VGDMQQQHQ.........QrLLN...................QQNnvmniQ...QQQSqqqplqqpqqqqkqqppaQ........QQ......LMS....Q...Q.......N..SlQATHQNP....LGT.Q.SN................VAGLQQPQQ
  480-  566 (83.73/17.51)	QM......LN....SQV............GN.....SS.........LQ..NNQ......HSvhmlSQ....PTVGLqrthQAGHGLYSSQGQQ..................................................................S..................Q........NQ......PSQ....QqmmP.......Q......LQ..S....HHQ.Q.LGLQQQpNL......LQQDVQQRLQAS
  572-  666 (102.30/23.39)	SL......LP..PQ.NVVD.QQR......QL.....YQ.........SQ..RTL......PE.....M....PSSSL....DSTAQTESANG............GDWQEEVY.........Q.KIK.................smKET.....Y...LPDL..................N.........E......IYQ....R...V.......A..A.KLQQDSM....PQQ.Q.RSDQLE.KL.............R.QFK
  667-  760 (139.30/35.11)	TM......LE..RMIQFLSvSKS.............................NI......MP....AL....K.............DKVAYYEKQ.......IIGFLNMHRP.........R.KPV...................QQG.....Q...LPQS..................Q........MQ......PMQ....Q...P.......Q..S.QTVQDQS....HDN.Q.TNPQMQ.SM......SMQGAGPRAQQS
  761-  866 (145.51/37.08)	SM......TN..MQSNVLS.SRP......GV.....SA.........PQ..QNI......PS....SI....PASSL....ESGQGNTLNNGQQV.......AMGSMQQNTS.........Q.LVN...................NSS.....A...SAQS..................G........LS......TLQsnvnQ...P.......QlsS.SLLQHQ.....HLK.Q...QQDQ.QM......QLK......QQF
  867-  952 (85.32/18.01)	QQ......RQ..MQQQQLQ.ARQ.............QQ.........QQ..QQL......QA....RQ....QAAQL...............QQ.........MNDMNDLTS........rQ.GMN..................vSRG.....M...FQQH..................S........MQgqranyPLQ....Q...L.......K..P.GAV..............SSPQL...........LQGASPQ....
  953- 1019 (76.72/15.29)	............M.SQHLS...P......QV.....D...........Q..KNT......VN....KM.................GTPL..................QPANS.........P.FVV..................pSPS.....S...TPLA..................P.........S......PMQ.......................V..........D.S.EKPGSS.SL......SM.GNIARQQAT
 1020- 1115 (65.61/11.77)	GM......QG..VVQSLAI.GTP......GI.....SAspllqeftsPD..GNI......LN....S.......STI....TSGKPSA....TEL.......PIERLIRA........................................................................................................vK..S.ISPQALS....SAV.S.DIGSVV.SMvdriagSAPGNGSRASVG
 1120- 1231 (63.76/11.18)	AM......TKcrLQARNFM.TQE......GM.....MA.........TKkmKRH......TT....AM....PLSVA....SLG.GSVGDNYKQF.......A.GS...ETS.........D.LES................tatSDG.....K...KART..................EtehalleeIK......EIN....Q...R.......L..I.DTVVEIS....DDE.DaADPSEV.AI......SSIG........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.47|      15|      19|      23|      41|       4
---------------------------------------------------------------------------
   27-   41 (30.81/24.76)	NWRPSLPNG......EPAMDT
   43-   63 (23.65/ 7.07)	DWRTQLPPDsrqkivNKIMET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.77|      13|      20|      70|      82|       5
---------------------------------------------------------------------------
   70-   82 (24.26/19.50)	FSGP.EGINELRRI
   91-  104 (19.50/13.82)	FSGAlNQTDYLRKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11312 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKQNFQSGNVPNPNSLLPSHIQQQQQNVLQPNQLHSSQQPGVPTSATQPSTVNSAPLQGLHTNQQSSPQLSSQQTTQSMLRQHQSSMLRQHPQSQQASGIHQQQSSLPQQSISPLQQQPTQLMRQQAANSSGIQQKQMMGQHVVGDMQQQHQQRLLNQQNNVMNIQQQQSQQQPLQQPQQQQKQQPPAQQQLMSQQNSLQATHQNPLGTQSNVAGLQQPQQQMLNSQVGNSSLQNNQHSVHMLSQPTVGLQRTHQAGHGLYSSQGQQSQNQPSQQQMMPQLQSHHQQLGLQQQPNLLQQDVQQR
2) METKSQNAAGSSAAIPAANNGTSIDSIPTNQGQLLPGSLSTNQSQAPQPLLSQTMQNNTASGMTGSTALPSSMPPVSSITNNNTTSVVNQNANMQNVAGMLQDSSGQHGLSSNMFSGPQRQMLGRPHAMSSQQQQQPYLYQQQLQQ
3) MHRPRKPVQQGQLPQSQMQPMQQPQSQTVQDQSHDNQTNPQMQSMSMQGAGPRAQQSSMTNMQSNVLSSRPGVSAPQQNIPSSIPASSLESGQGNTLNNGQQVAMGSMQQNTSQLVNNSSASAQSGLSTLQSNVNQPQLSSSLLQHQHLKQQQDQQMQLKQQFQQRQMQQQQLQARQQQQQQQLQARQQAAQLQQMNDMNDLTSRQGMNVSRGMFQQHSMQGQRANYPLQQLKPGAVSSPQLLQGASPQMSQHLSPQVDQKNTVNKMGTPLQPANSPFVVPSPSSTPLAPSPMQVDSEKPGSSSLSMGNIARQQ
4) QASGQVTGSLLPPQNVVDQQRQLYQSQRTLPEMPSSSLDSTAQTESANGGDWQEE
259
111
704
564
562
256
1017
618










Molecular Recognition Features






MoRF SequenceStartStop




NANANA