<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11303

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSSGGVGDVPIEQLLQELPLEDSNLVNLSVLVERLSNLAYQTIQSLSDTLPSLTSHAKRAKIFSTAIELRKIFVKLLVIVRWSKDVEMLNRARNVIGLLVEQQWAHEDVFSGLTQVRKILPNARMFDADLVTAIDILRTGTYNRLPKAIKDSTVPQEPMTDSEALEVMSQLDMVLRERLAYSELTPLGLYLSKIESGKAYFEAPELYNICLTTSGPAEDDRWWLLDFSFVDQVSELENLDTILTDPYLDHVYGTSDSILEQSSSNDDARPTLTRLHEFLEQESLQRQLHILYHQLENMFRFNWGSSIRFMLNAESRSLEIFYWTSHSVGATQKTEKTLLQGQLTLTLKTKERIGKDKVVSEIFSGSDAVSHSSFIEVNWSTDDRIQTYLTPEERNIQLKNLDGEELVLRTIQMHSMALMKFFQERIISHNGLSAGSSNICTLRMHAGSKYEPRNCLQLYVTDTIKIVLFVSVITGRLGLKMLESVDSANGLSLSLSQSHDVSLLRLADQINANISQLTELLFTFRLKCLRTDVQTQASWMGLPYLTSVMLGPGELKKLGISDGHPLLFLPLIVIPGFYLMLYFVPGRPLSMALISILTQNDEGKSMQTINSVKWLDKDQLSQYSITGQDLVHVPKRNAPEVSMTTSRYEGIQSRELELALHYCIATVVYSHLEVQFRLKLIPFMLVGATTNMTAPPESSPDPLLPSLCIHAKELLGPSADLASPNVSLQICDWWLPAQRRVEISMKLHLKTTLEGGDIVLFEGAILNLGTGVLKLICKDLTTVIDTLHQYWDQAARMCLLVNSISQYSGKRLNVSLKSVDHTYVRFLYEPTEKEAQKLHLSASIKFYGPNQSNRQRFGLDFSVDEYGHENKEATRRNPHSLIATVLGRSLDSLAKERMDIWYSMFQTNYQMLEITFPVLQTLEPLYYEALTNPDCPDVEIRDYNWFRIHFSENYTMDIRIISKERIMLSDSKSDLYLGQSNHQVHRESQDKNVLSAWTVMQQQQSLHLPNKPNDIPEEKKQIRNKENNIIILNYKDIICLNDIINFLK
Length1048
PositionTail
OrganismMalassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.08
Grand average of hydropathy-0.184
Instability index43.45
Isoelectric point5.68
Molecular weight119378.53
Publications
PubMed=28100699

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11303
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.87|      11|      45|     901|     911|       1
---------------------------------------------------------------------------
  901-  911 (24.73/17.86)	WYSM.FQTNYQM
  945-  956 (19.14/12.06)	WFRIhFSENYTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.04|      24|      46|     211|     234|       3
---------------------------------------------------------------------------
  211-  234 (44.43/28.16)	LTTSGPAEDDRWWLLDF.SFVDQVS
  259-  283 (35.61/21.15)	LEQSSSNDDARPTLTRLhEFLEQES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.32|      18|      46|     584|     603|       4
---------------------------------------------------------------------------
  584-  603 (26.94/22.47)	VPGRplSMALISILTQNDEG
  633-  650 (30.38/17.64)	VPKR..NAPEVSMTTSRYEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.88|      26|      44|     383|     426|       7
---------------------------------------------------------------------------
  383-  408 (43.62/43.22)	DRIQTYLTPEERN.IQLKNLDGEELVL
  442-  468 (40.26/12.34)	LRMHAGSKYEPRNcLQLYVTDTIKIVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.77|      20|      21|     680|     700|       8
---------------------------------------------------------------------------
  680-  700 (32.34/23.34)	LIPFMLVGAtTNMTAPPE..SSP
  703-  724 (30.43/17.08)	LLPSLCIHA.KELLGPSAdlASP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11303 with Med14 domain of Kingdom Fungi
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