<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11303
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MSSGGVGDVPIEQLLQELPLEDSNLVNLSVLVERLSNLAYQTIQSLSDTLPSLTSHAKRAKIFSTAIELRKIFVKLLVIVRWSKDVEMLNRARNVIGLLVEQQWAHEDVFSGLTQVRKILPNARMFDADLVTAIDILRTGTYNRLPKAIKDSTVPQEPMTDSEALEVMSQLDMVLRERLAYSELTPLGLYLSKIESGKAYFEAPELYNICLTTSGPAEDDRWWLLDFSFVDQVSELENLDTILTDPYLDHVYGTSDSILEQSSSNDDARPTLTRLHEFLEQESLQRQLHILYHQLENMFRFNWGSSIRFMLNAESRSLEIFYWTSHSVGATQKTEKTLLQGQLTLTLKTKERIGKDKVVSEIFSGSDAVSHSSFIEVNWSTDDRIQTYLTPEERNIQLKNLDGEELVLRTIQMHSMALMKFFQERIISHNGLSAGSSNICTLRMHAGSKYEPRNCLQLYVTDTIKIVLFVSVITGRLGLKMLESVDSANGLSLSLSQSHDVSLLRLADQINANISQLTELLFTFRLKCLRTDVQTQASWMGLPYLTSVMLGPGELKKLGISDGHPLLFLPLIVIPGFYLMLYFVPGRPLSMALISILTQNDEGKSMQTINSVKWLDKDQLSQYSITGQDLVHVPKRNAPEVSMTTSRYEGIQSRELELALHYCIATVVYSHLEVQFRLKLIPFMLVGATTNMTAPPESSPDPLLPSLCIHAKELLGPSADLASPNVSLQICDWWLPAQRRVEISMKLHLKTTLEGGDIVLFEGAILNLGTGVLKLICKDLTTVIDTLHQYWDQAARMCLLVNSISQYSGKRLNVSLKSVDHTYVRFLYEPTEKEAQKLHLSASIKFYGPNQSNRQRFGLDFSVDEYGHENKEATRRNPHSLIATVLGRSLDSLAKERMDIWYSMFQTNYQMLEITFPVLQTLEPLYYEALTNPDCPDVEIRDYNWFRIHFSENYTMDIRIISKERIMLSDSKSDLYLGQSNHQVHRESQDKNVLSAWTVMQQQQSLHLPNKPNDIPEEKKQIRNKENNIIILNYKDIICLNDIINFLK |
Length | 1048 |
Position | Tail |
Organism | Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina>
Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.184 |
Instability index | 43.45 |
Isoelectric point | 5.68 |
Molecular weight | 119378.53 |
Publications | PubMed=28100699
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11303
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.87| 11| 45| 901| 911| 1
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901- 911 (24.73/17.86) WYSM.FQTNYQM
945- 956 (19.14/12.06) WFRIhFSENYTM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.04| 24| 46| 211| 234| 3
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211- 234 (44.43/28.16) LTTSGPAEDDRWWLLDF.SFVDQVS
259- 283 (35.61/21.15) LEQSSSNDDARPTLTRLhEFLEQES
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.32| 18| 46| 584| 603| 4
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584- 603 (26.94/22.47) VPGRplSMALISILTQNDEG
633- 650 (30.38/17.64) VPKR..NAPEVSMTTSRYEG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.88| 26| 44| 383| 426| 7
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383- 408 (43.62/43.22) DRIQTYLTPEERN.IQLKNLDGEELVL
442- 468 (40.26/12.34) LRMHAGSKYEPRNcLQLYVTDTIKIVL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.77| 20| 21| 680| 700| 8
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680- 700 (32.34/23.34) LIPFMLVGAtTNMTAPPE..SSP
703- 724 (30.43/17.08) LLPSLCIHA.KELLGPSAdlASP
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