<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11297

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEQAVNGLVMNGTTSHLPLPLQNGDLVLHEPSPEELERELPVVTDGQVPLGELTSRLVQAMYAELTEFAETMPTMSDAARKRSLADWVVKFKRQVVKLYAIAKWSRDASVVQKAMNITAFLMDQNGQFEEAIMGLKYGKESLDPARLRNHDLLTSLDVLTTGTYRRLPSCIKELIIPPVPLTDEEVAKTLADIEDAMRYRLRTSEIVPWELSQYRIADGRVWFTAPKLFEASLCLQGAGKTDGWFFVNVTFLFKVGGDLTGMQDFPRTPTGVLKRNITDEADARLAFYLPPEAPPPPGVEAPPRPELPEGVVDAPLVRVFNFLQMMSLSYQLEILWYQAEHMRSLGWADYLKVEMTNNRQKMVVSYWLWKPLPGQQASSQARNRAPQLGGKLSISITRVKEKTGRQAMRSPKARVLAELQERSKLERARPSDEVEHLRFDVQWEPAQGTLGVNIGPEDAYIPPEQLAIDPNDLDFEGLLRRVIRRHTEGIMKYFQRDLMQNAHTRNVFSAPGEVTFVTNEGTPSLRVHLCADEVVIVTVDPRTGRLTLCDTGDLAAAGRGPRFAAISDRLNDSPQRLPEALIRLRLSTITDLAEQKVQYVGLQSFRERNFLPEEIAKLGPDARGKLYIQLANFTSHYLVLVITDNDYRYALINVKVQRDTMYNNLIMEDIGWLDIHRLHTGDMVVEPGHGPEPVVGQKRKRDDRDEVPVVPAAPAEQNPTSFRLETKVLRELYAYCCARVAYTKVEQQFKLRQIPYTHVNSTASIGALDAAHIQSSLARSIPALCVLSRDILSGAPAEEAAMPNIRVIPLNWWSNDQAKVVTCVKLKYVQQPIGKRASGTSVIRPSKRIVYDTREAIVSFLSDDVDKCVDEFLEEWARVSKMVVIAREVAQMSTKHLWTDVRLLSFDLQTVEFAYAADYTLSLTCTDQLTSTGGSYHLRFGRVEHDDEMEVDGEPLRTTHNPHEDVEPYMRNLLRHGPLTSTLHRLVSLLRETLPIVAELEEIRAAAARSGVVVDTFAKSAGWFRILYGDLRHALDFRLMAGARVVILDGSHSLFDDSADGHTLRRLSGPSKAFASRDREPTAALQPIPDFRALVQDAIKGAVARGVAGQFAPIDIGVICDVSAVRVVGRLLYERVLEKLAAQAGPHL
Length1148
PositionTail
OrganismTrametes pubescens (White-rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.07
Grand average of hydropathy-0.234
Instability index41.90
Isoelectric point6.15
Molecular weight128730.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11297
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.00|      34|      35|     568|     602|       1
---------------------------------------------------------------------------
  568-  602 (50.86/46.00)	DRLNDsPQRLPEALIRL....RLSTITDLAEQKVQYVGL
  603-  640 (51.15/40.46)	QSFRE.RNFLPEEIAKLgpdaRGKLYIQLANFTSHYLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     501.97|     188|     284|     649|     852|       2
---------------------------------------------------------------------------
  176-  321 (182.52/119.93)	...............................................................IPPVPLTDEEVAKTladiedamRYRLRTSeiVPWELSQY...RIADGRV..WF...TAPKLF...EASLCLQGAGKTDGWFFVNVTFLFKVGGD.LTGM.QDFPRTPT.GVLKRNITDEADARLAFYLP.PEAPPPPGVEAPprpelPEGVVdAPLVR.VFN
  322-  386 (37.40/13.03)	FlQMMSLSYQLEILwYQAEHMRSLGWadyLKVEMTNNRQKMVVSYWLWKPLPGQQASSQARNRAP................................................................................................................................................................
  649-  852 (282.05/241.53)	Y.ALINVKVQRDTM.YNNLIMEDIGW...LDIHRLHTGDMVVEPGHGPEPVVGQKRKRDDRDEVPVVPAAPAEQNPT........SFRLETK..VLRELYAYccaRVAYTKVeqQFklrQIPYTHvnsTASIGALDAAHIQSSLARSIPALCVLSRDiLSGApAEEAAMPNiRVIPLNWWSNDQAKVVTCVKlKYVQQPIGKRAS.....GTSVI.RPSKRiVYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.23|      20|     527|      14|      33|       4
---------------------------------------------------------------------------
   14-   33 (35.23/20.15)	TSHLPLPLQNGDLVLHEPSP
  522-  541 (30.85/16.74)	TPSLRVHLCADEVVIVTVDP
  543-  561 (31.16/16.98)	TGRLTLC.DTGDLAAAGRGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.93|      55|     926|      34|      90|       5
---------------------------------------------------------------------------
   34-   90 (86.93/70.33)	EELEREL.PVVTDGqvPLGELTSRLVQAMYAELTEFAETMPTMSDAARKRSLADWVVK
  964- 1019 (85.01/61.97)	EDVEPYMrNLLRHG..PLTSTLHRLVSLLRETLPIVAELEEIRAAAARSGVVVDTFAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11297 with Med14 domain of Kingdom Fungi
Unable to open file!