<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11294

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAKGEKEPLPVYELRPPEWLPTAHTSGDIGYIGFYPPRPNDVEETLTEANVKHGLVLKPEVLAEHYSQQHEIRKRLMQDDALSVLEDVMNQIFARKAESVPPIPSSSFRLPSRVTLNDGKRLAWFADLANPDIPLSKLGKNVPHGAKGHDLLDLLHTNNVAIPRAVWFLRVFGANESAGLRNRPSYNPTQYSVEWANVMTSYMKKQLADIALPSAPRLVASIKQTFKGVLSDVDMRQKWISRFTYCLSLLRTFYAEGLVDNRTFLAWLVQQMSTCNLAQAGFVVRLADEYLDGMLVSRALTRPFIEASLVKLEEMKEPPANEFLPDTTNILKSLISRAFLALPDACICPRMHIQYGARLQEVLMENFGADGAESSQVSIQALRQTVLDTLSDIQRRNEAMLFEHLPPRVLGSLSSALSDVKLLNSISGKTDMSSVSLFDDNSEISPSFSRKLDFLMTWSVTPLQYGDHRPYAAACLLQIWRNKAEERALRRDAPSPDGQIQDLLFDWLDGSDVAGESGNLPAVALLFGQLVKRELFSYEQYMQRLIARGETGLSFGEEEGSRHRHFLRWIPLNSSDASVISQRKVILYGFRVRETPEDANEREIRKEFRILVPEVFGGEPQTDEPLTTTFWKSCGALLSAPRYEQLKIMKQWFLPIYKRFLTSQGFDDDGRILRVFTLSTVIMARVRSYGSILDMSLYTLEYANNSALLTAVIETLRQHIEVWACMDRMKDVASALWTVHQTWRSRGLQNRVLLKLLAEVDNEQHLDPAAREQMLSDISAFSHALFPSNENPDQVPQVLPEILLLATDPNPEAPSLLANSLWYKYMTSSDWAYKVWDNTVASLRQIPVMIEDVAGRRACALRYATFLLHVDQHLPRGLDEQIRSWFLAPLGRSEVAALTPETWDVVTVVLLYLICYGALTTTTMLESLIYNEWEEGAKVTSDEKAQARETLLTWSNTLFEHLLLRDECGTGLPPVDVFEAQGLQTRRRDVFREPYFSNLVVRFPDLVLIEQNRYLPEALRQATTNLRRTICRVSVFRQGIYRDLDSVRLAFEERLNPQNDELHEPLVSALRLMLNDPGQDGPVNAAEWSSASSLLSPWKLAATAIEIRLTIKQLGDGMSRESTRIAACASLDKLTGGVFYHCKSPEEADFVAEMITNVHKTVAGKFVNAGLKRIDDIIRETDGANKINSMTLLVSSAGEILRLIANIVAPFRLETSRPEKDQGDESRTEPNLPPIDAAVQEHLFTVLCAKFAEMTGMMAALVQEPWSEDISRGSQAVIFLARLLQFYLGFPAVWSDKSKELAEELCANLTRLALIHGSGEGLNMLAFPLIMDTLCYTLDSIPSDMKATAPFDPFRYYPEFNLSDLPSDMPLEYKARLRLMLPYVALNPTVEDLVYATRDAAGALVPTGPVQNRPWEWTEYIGDVAGAPADGGAVRNSAALALELFEARLTGDRVIPADARADGMMEENLHSMQDDVYAEGAFARDWRETRISLDDVPSSASAGRGRHEQDDGVPPLPALGGTPAAAADHRGLPRKPSPASSVRSVGSAHAFSRLSVSTAGEVIDVDALDGGTSGSGSTHKRKAMSSITEEDDDEVEFVEGPIPARPAKRTAKSKMAGKTTKGKKR
Length1625
PositionKinase
OrganismTrametes pubescens (White-rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index48.46
Isoelectric point5.39
Molecular weight181495.75
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11294
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.68|      45|     111|     203|     257|       5
---------------------------------------------------------------------------
  203-  247 (74.77/34.97)	MKKQLADIALPSAPRLVAS.IKQTFKGVLSDVDMRQKWISRFTYCL
  315-  359 (69.54/31.70)	MKEPPANEFLPDTTNILKSlISRAFLA.LPDACICPRMHIQYGARL
  373-  398 (21.38/20.37)	..........ESSQVSIQA.LRQTVLDTLSDIQRRNE.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     379.68|      93|     909|     423|     523|       7
---------------------------------------------------------------------------
  423-  523 (158.40/108.69)	LNSI.SGKTDM............SSVSLFDDNSEISPSFSRKlDFLMTWSVTPLQYGDH.R...PYAAAcllqiwrNKAEERAL..RRDAPS...P....................DGQIQDLLFDWLDG.SDVAGESGNLPAV
 1338- 1434 (128.16/72.21)	LDSI...PSDM............KATAPFDP.FRYYPEFNLS.DL...PSDMPLEYKARlRlmlPYVAL.......NPTVEDLVyaTRDAAGalvP....................TGPVQNRPWEWTEYiGDVAGAPADGGAV
 1466- 1574 (93.12/50.29)	EENLhSMQDDVyaegafardwreTRISLDDVPSSASAGRGRH...EQDDGVPPLPALGG.T...PAAA..........ADHRGL..PR.KPS...PassvrsvgsahafsrlsvstAGEVIDV..DALDG.....GTSG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.19|      26|     711|     154|     180|      11
---------------------------------------------------------------------------
  154-  180 (43.87/34.80)	LLHTNNvAIPRAV......WFLRVFGANESAGL
  867-  898 (42.32/28.28)	LLHVDQ.HLPRGLdeqirsWFLAPLGRSEVAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.24|      29|     821|     272|     302|      12
---------------------------------------------------------------------------
  272-  302 (47.42/42.02)	MSTCNLAQAGFVVRLADEYL.DGMlvSRALTR
 1095- 1124 (46.82/34.29)	LSPWKLAATAIEIRLTIKQLgDGM..SRESTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.94|      28|     421|     535|     568|      13
---------------------------------------------------------------------------
  535-  568 (45.22/46.31)	LFsyeqymQRLIARGE..TGL...SFGEEEG..SRHRHFLR
  958-  992 (35.72/22.11)	LF......EHLLLRDEcgTGLppvDVFEAQGlqTRRRDVFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11294 with Med12 domain of Kingdom Fungi
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