<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11291

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAAKVQLPQDNTGSSVLSQMPPSVSLASSILASTISLPESPLIVYHIFACPPATPDSLDHLDLARRKVLHSNKSQAFPESLLPIVHVTRDVCALYVFALGSIHRTCDAHDTLAKLELDNLISSKLHPNGRSVTRLKSGFLLGAVPSSSEWGSGWESHAHSRPLIHCDLQIHIAFSASTPTLARLIVHPVMRPTYYLPLGIALPLPAGTPVILLPHGVPAYYLNTYTGPTGALLAQFDDALLGLGVGNWKSATPCSGSAGNSSRSHRSSSRQDRPIFVIAWLAVQNKQGEDKGMPVVWPASLCVSYHASSPSPHARSPLPYIPELPAQLQSSPPPPMSAVPTSLSFAMATSSSIDIPARSSTPQSQGPGSSNIERERLSISFQRRPSFLRSSPTSDSLRAFRSLTLARRPYGRQMKKVAAEVSGYVESVVRERELVRAQLRRGKQEKEQQEQEAAQRARLAGIQPRQTTEPPTPALVQREPVETAQVNAAVTPPDSAEPAVQEEPVEPESHSTGSDHSGDSLFSPPDAPIDLPSTEDEAPAAPEPAQEATAPPAGEEIVLALPVKSEAEPSSMAFDPFNGFDGTWGQQSTGYMDTNMYDMDFSMNIDPLGGGRTSGVGGGSSSFDMDDGFGVFTEDDFDFFDAPSAQRGAPSAHSMVVDTGSGLTPAAGPPPLGLTPLVAVDGPLSGPGPPSASMNHSSPWTAHLGDPFTPRTHGDMHGMMDSSVPPDLLPPSPTRTPSSYSAPATPSVQLSDPYKGHDARKSSISSLGSSTFDSIPFASSHREADGKYAVGKFALPSPPAELDRPEIMLASATGPPSLAGWKYRYSVVTDPRIGVVRKLIGVKRKVQSQGVRDQRRSSAWDFYREPEEWQSSSPPSAAVDSEESEDDDEPWVEEEETTTSVAPRPSTPPPSYLPLGPTLLQTHFHHAHLLPLCTTLRPPGTAASSPPGHAPIISVPTPVSPAAILGAASEKSKSLEAAAQILVREVVENPVWAEAWRANASLSLTPPTLPAKLWQADARFISKLLGDGRNAHSSAGIQDVFGVVSDEQSAVSLRNLEPPLLAVGKDETVVQLSSTSLRFWEKLGLTPRAGPKDVTAFVFYEGADEERETELESWLDKVSTAYAAKNFGSHVAGISSHCTKPGLVPTRFDTLRKTLMSFVSTIPTRHPYLVFYIATPSHIISPSSTVLRQILSAVRRFRAQSAGDILIHFVPESLIEGIHTHPASNLGGLDDFVCSVYDRILVPVTRAMSREFFARSAVMTGYFEAPAYALICTAGNKSRSEPLPPQVSFALESSVSSLDVMNRHMLLHVGYQVSSCGRWILAACIDAAGEAHEIKAFLTPDDNVESFLVSHVWGFVHDFARRANIEWRIVITKLGIMSHSEVSAWVSHLDSKVSMSSEIPPIHVTLLAVDNENPWTFLAPSDVGPLDIIRRNSAPAVPTRSSIRTSHTVFSDASYATYSLSPPQGLAMHPSYVVERSTKCIPPMVTPGSSDLPYIPDLDDETDTAPPQHPATDALRVPGWSAVVCAPSTADHSSVSTMRVFQLCVTRSLRSTYEISKKNAAVTPSQIHSEHMDDIVRNFYDLSLLARVRWKLRADPALPFHLAALEVMRAALSGGTNES
Length1619
PositionKinase
OrganismTrametes pubescens (White-rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.07
Grand average of hydropathy-0.222
Instability index62.79
Isoelectric point5.80
Molecular weight174248.31
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11291
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1058.94|     179|     183|     689|     867|       1
---------------------------------------------------------------------------
   41-  187 (152.19/56.11)	PLIVYHIF.......AcPPA.TP........................................................................................DSLDHLDlARR..KVLHSNKSQAFpE.......SlLPI..........................V.............HVTRDVCALYV...FALGS.....IH..RTCDAHDTL..AKLELDNLISSKLHPNgrS........VTRLKSGF...LLG...........................................................................avPSSS........EWGSGWE..SHAHSR...PLIHC.DLqiHIAFSASTPTlARLIVH
  188-  391 (139.07/50.62)	PVMRPTYYlplgialP.LPAgTP.VILLphgvpayylntytgptgallaqfddallglgvgnwksA.............................................TPCSG.S.AGN..SSRSHRSSSRQ.D.......R.PIFviawlavqnkqgedkgmpvvwpaslcV.............SYHASSPSPHA..RSPLPY.....IP...EL..PAQLQSSPPPPMSAVPTSLSFA..M........ATSSSIDIPAR....SSTPQSQ.GPGS..sniERERLSISFQR................................................................................................RP.SFLRSS
  392-  541 (150.00/55.20)	PT....SD.......S.LRA.FR.SLTL.....................................A............................................rRPY.GRQ.MKKvaAEVSGYVESVV.RerelvraQ.LRR..........................G.............KQEKEQQEQEAAQR..............ARL..AGIQPRQTTEPPTPALVQ.REP..VetaqvnaaVTPPD........SAEPAVQEE.PVEP.....ESHSTGSD.........................................................................HSGDSlFSP...P.D....APIDLPSTE.DEAPAA
  542-  732 (190.79/72.28)	PEPAQEAT.......A.PPA.GE.EIVL.....................................AlpvkseaepssmafdpfngfdgtwgqqstgymdtnmydmdfsmniDPLGG...GRT..SGVGG.GSSSF.D.......M.DDG..........................F.............GVFTEDDFDF....FDAPSaqrgaPS..AH....SMVVDTGSGLTPAAG...................PPPLGLT.PLVAVDGPLSGP.G...................................................................PPSA......SMNHSSPWT..AHLGDP.FTPRTHG.DM..HGMMDSSVPP.DLLPPS
  733-  916 (268.00/104.60)	PTRTPSSY.......S.APA.TP.SVQL.....................................S.............................................DPYKGHD.ARK..SSISSLGSSTF.D.......S.IPF..........................A.............SSHREADGKYAVGKFALPS.....PP..AELDRPEIMLASATGPPSLAGWKYRYS..V........VTDPRIGVVRKLIGVKRKVQSQ.GVRD.....QRRSSAWDFYREPE.......................................ewqsssPPSAavdseeSEDDDEPWVeeEETTTS.VAPR............PSTPPP.SYLPLG
  917- 1147 (158.89/58.92)	PTLLQTHF......hH.AHL.LPlCTTL.....................................R.............................................PP..GTA.AS......SPPGHAPI.I.......S.VPT..........................PvspaailgaasekSKSLEAAAQILV.REVVEN.....P.vwAEAWRANASL.SLT.PPTLPAKLWQ..............ADARF..ISKLLGDGRNAHSSaGIQDvfgvvSDEQSAVSL.RNLEppllavgkdetvvqlsstslrfweklgltpragpkdvtafvfyegADEE......RETELESWL..DKVSTA.YAAKNFGsHV..AGISSHCTKP.GLVPTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.41|      24|     341|    1058|    1094|       2
---------------------------------------------------------------------------
 1058- 1094 (33.66/42.25)	PP....LLAVGKDETvvqlsstslrfWekLGLTPR.AGPKDV
 1400- 1428 (37.75/19.62)	PPihvtLLAVDNENP...........W..TFLAPSdVGPLDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.45|      38|     341|    1161|    1198|       3
---------------------------------------------------------------------------
 1161- 1198 (66.00/30.02)	TIPTRHPYL.VFYIATPSHIISPSSTVLRQILSAVRRFR
 1504- 1542 (64.45/29.16)	TAPPQHPATdALRVPGWSAVVCAPSTADHSSVSTMRVFQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11291 with Med13 domain of Kingdom Fungi
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