<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11289

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMFTGWRHAVETLAQPVKPAGSPEAAASGEDAPVRSSLDSLAIRTSTSSPAHLAESALSTLRKTLVAQRPASPANAANGNAQASTSSPEPAPTPATKPRSGTRTTLEDRLRAKFAIGDASNQSTPATSSRASPAPVSAADHPLALPSSGSSTSDIPIVKGPPNPLSPTSTPLPDSPMVSPTPVHAQSMIATAANISVASLPGPLSEPSESGAETAEPPAIDAETDVPEATPTPEVAGPPAVSADDVQEDSSEHSPPEEVSDAPPASATTESPEPVEITPEVTEPIEVPNEESAAEAVPAPLPLPEVSQEVAPTIEDAPVNQQPEPEVEPESLPAAVELVEPSPEPQPVIVEDTAPSSDVSPPVALASPALLDADASLPRRSLDIPSRATTPDVEDVSTSFKRLQAEKLAADRVLRELTSVESVTEVDALRDFLQNLTLKNEMAQDEIRRLSGKLTRQDERIEELRDIHRLESKSQSDQIDKLKAQVEEAEKLLKAAQSTTAQIEQESAKRKAEIDRLHGEVEHATGSAKDEEEKRTKAITLLKTVRQKLVKAEKERDDAVKEVGTVREAEKAEREKERAERARLQGEIEKANAERETAVQGLRAQFDKEVAGLRDKHEKEIAALRGQFELEAITTKTTHVREIENKKNRISDLESRVKTLSEEKDELFDQLQLRQAELESSQSALESLQGQNTELQYQLREANDRAALMQDEFSDVRREQDVRTLSPGPSAEEVARLLASAESKYESKMGDLRRRLSEAERERDEADARWSRKFAERAKEVDELTAAIRSSQQSKEEDTEGRQALQAQVEALQAEIRAYQQQIADLHTELEKAAELEVSAKTQLAEVASKIADLQQHVDESKNREAQLRAQNKTLREELRKVQSSVALLEKQRNPGVGYWASRNESTSELRSPRSSVSDLARETPSRPSTPTAAKSDEEVNFEYLRNIIMQFLEHKEMRWIGLCKLFISKNLSHSSSHSIETDISNSVLILFRDYPGDPALQAYLKQAIQDGVLSLPTFLTTFLAAAQSPELHNTATLDMLCSVALEHHYASGLPPTGSLIPYGEPTARLLNTVQNAMALLRTAYGLPMAHFHQLTTGASQLLVLLLSCATEPAQLATAQAVMHLADVHELLQLARLSPPNVRGVLEGFVWSLGMLMGDDAKVAREAQLMHLSSGKGDTILGSSSDTDIVTCTLVLNHLIFNRAGDFGSGDGPHAVAILVSLLRWSAWTPATFYSQLIISALTCFAQSISPTGPTRASSIWRAFTIGRLPHLLAQFQKSAQSEGIGEAEWHTALQFALPAILHRGDLLEKIDNIGQTGGSDTGSEKSVIFTSEFLYQLLHVGLIEQAVVTTINPNFPNDFHPRVAAEAHEAGLDLPGYFEVKLSPDASPEDIEVLLYRAWKDPCCHSAFAEVVEKRFTSSTKNVDTETLSLVCKMLCQHEMALDMLSLHTKISDLVAHALAFVEDYDCETVGDPQTAVTHLGDVVLFVEATIARFNLGTHSFSVGERHLNPEFLRTSGPNLRVDELKEEDLSAFNSWIKALFDPSSEGIEDTILRATRPKVLLRIAPTLFSHAITQCMERKMDKEALLNGISYFLAPLLNWTLARVIKFLLSEIQRRG
Length1617
PositionTail
OrganismTrametes pubescens (White-rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.04
Grand average of hydropathy-0.399
Instability index56.72
Isoelectric point4.98
Molecular weight176523.87
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11289
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.81|      17|      19|     298|     314|       1
---------------------------------------------------------------------------
  227-  241 (21.49/ 6.48)	EATPTPEVAGP..PAVS
  270-  285 (25.25/ 8.97)	SPEPV.EITPEVTEPIE
  298-  314 (30.07/12.17)	APLPLPEVSQEVAPTIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     267.22|      59|      64|      97|     155|       2
---------------------------------------------------------------------------
   22-   73 (60.56/23.27)	.........PEAAASGE.D........APVRSSLDSLAIRT.STSSPAHLA.....esAL.....STLRKTLVA.......QRPASPA
   74-  114 (58.01/21.96)	..NAANGNAQASTSSPE.P........APTPAT........................kPR.....SGTRTTLED.......RLRAKFA
  115-  187 (90.35/38.50)	IGDASNQSTPATSSRAS.P........APVSAADHPLALPS.SGSSTSDIPivkgppnPL.....SPTSTPLPDspmvsptPVHAQSM
  188-  217 (28.10/ 6.67)	IATAANISV......ASlP........GPLSE.......PSeSGAETAEPP.....................................
  341-  387 (30.20/ 7.74)	..............SPE.PqpvivedtAPSSDVSPPVALAS.........P.......ALldadaSLPRRSLDI.......PSRA...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     423.52|      63|      64|     791|     853|       3
---------------------------------------------------------------------------
  496-  550 (39.27/20.19)	...........Q..S.TTAQI....EQESAKRKA...EIDRLHGEV...........EHA.TgsakdeeEKRTKAITLLKTVRQKLVK.
  553-  612 (57.04/33.28)	...KERD....D..A.VK.EVgtvrEAEKAEREKERAERARLQGEI...........EKAnA.......ERETAVQGLRAQFDKEVAGL
  613-  659 (43.22/23.10)	.....RDKHEKEiaA.LRGQF....E.LEA...........ITTKT...........THV.R.......EIE.NKKNRISDLESRVKTL
  660-  721 (72.52/44.68)	SEEKDELFDQLQ..L.RQAEL....ESSQSALESLQGQNTELQYQL...........REA.N.......DRAALMQDEFSDV.RREQDV
  727-  783 (61.05/36.23)	GPSAEE..VAR.....LLA.........SAESK.YESKMGDLRRRL...........SEA.E...rerdEADARWSRKFAERAKEVDEL
  791-  853 (94.62/60.95)	QQSKEEDTEGRQ..A.LQAQV....EALQAEIRAYQQQIADLHTEL...........EKA.A.......ELEVSAKTQLAEVASKIADL
  854-  919 (55.79/32.36)	QQHVDE.SKNRE..AqLRAQN....KTLREELRKVQSSVALLEKQRnpgvgywasrnEST.S.......ELR.SPR.......SSVSDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.52|      47|      64|     996|    1046|       4
---------------------------------------------------------------------------
  996- 1046 (70.41/60.01)	GDPAlqAYLKQAIQDGVLSLPTFLTtfLAAAQSPELHNTAT..LDMLCSVALE
 1063- 1111 (76.11/51.15)	GEPT..ARLLNTVQNAMALLRTAYG..LPMAHFHQLTTGASqlLVLLLSCATE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      17|      17|     436|     452|       5
---------------------------------------------------------------------------
  436-  452 (28.23/18.80)	TLKNEMAQD..EIRRLSGK
  454-  472 (23.83/14.64)	TRQDERIEElrDIHRLESK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11289 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKAAQSTTAQIEQESAKRKAEIDRLHGEVEHATGSAKDEEEKRTK
2) RDDAVKEVGTVREAEKAEREKERAERARLQGEIEKANAERETAVQGL
3) TGWRHAVETLAQPVKPAGSPEAAASGEDAPVRSSLDSLAIRTSTSSPAHLAESALSTLRKTLVAQRPASPANAANGNAQASTSSPEPAPTPATKPRSGTRTTLEDRLRAKFAIGDASNQSTPATSSRASPAPVSAADHPLALPSSGSSTSDIPIVKGPPNPLSPTSTPLPDSPMVSPTPVHAQSMIATAANISVASLPGPLSEPSESGAETAEPPAIDAETDVPEATPTPEVAGPPAVSADDVQEDSSEHSPPEEVSDAPPASATTESPEPVEITPEVTEPIEVPNEESAAEAVPAPLPLPEVSQEVAPTIEDAPVNQQPEPEVEPESLPAAVELVEPSPEPQPVIVEDTAPSSDVSPPVALASPALLD
492
555
3
536
601
371










Molecular Recognition Features






MoRF SequenceStartStop




1) LEDRLRAKFAIG
2) MFTGWRH
3) SALSTLRKTLVA
105
1
55
116
7
66