<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11282

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGIFLHRCLLHRIDAAEFKSLSRLLLQRCPITEALLLDVLLETRLSTGIKWDPLLPLYIDCLCKMGLVQTSTVLKALLKHSSIHDKNQSSSVEVYPGKKSRSCYTLMTDIRVVQDAMLSVSTGSVPKSFSEAISIFTAIIDWIQAVVAWNSSHIDSGHQNPGLISSPDAVSLFESLGILLAALSGTTKGLEVLSADSQEALKVKLGQALSAYLPICVEVSLPLRNRLDSLQKEFNLYGETPAKPLDVSMMEGVNVNALQFEASVMDGPMINSRAGLFVYINAMLVGRPLVDDSMLLNYLSNRYGGHYEVLIEETITAAFDVLSNASYRSESNRSMFLFRSFLVNKLPAFFAAMLAASMVTLPMELCISHALGRLDPNTFPSFSQMFTMQSNTALSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDDLVNQINANPERAEHLIGEIESMEGNAGAIVGAIIEVMHNLCNQKETMTLKNICNSLSRRPQAMDVILLFRSTKQVLQPLCSLLDAWHWDEDQGESQPVYDEFGSILLLVLAFTYRYGLRAHDLGLGGSNSFVLQILGGGSCSQKLDSLSDKQNKNLGGWITALFIAEGISEETMSACSPQEFYLLVATLFSQSLGACEAGKLEFDTLKGGSEYLLEPFLLPSLVLALNWLGNHIWETEGDPSIPLKALHSLINPTSISGEAKEIHRTVLNMTARRLEEQLKDVRARHPSRTDIKPILDALEPCLSFERSGSCHRSELDSWTSHSPGGLLGSIRSAFQSLVLWSASPHVSVAPHSYTHRQLVTGVLLLGATRVLGALVEELKLQTETGSGDIALDIAATLICAPMAEYFAIDQNNHSHQPLDPTKESFPRCPILTLRSALNLLHDNIPKISEKDPSRAEVIVRLYRRVNALMTPPAQVPNLDMNNIIQHMQLGVGGPGQMDLDPQGASGHGVTDDDAANLNRMLDNAAAAAVVGMDGGQTMGGIGLESSSGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF
Length1024
PositionTail
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy0.032
Instability index46.18
Isoelectric point5.08
Molecular weight111733.74
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11282
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.40|      24|      72|     926|     949|       1
---------------------------------------------------------------------------
  926-  949 (43.56/25.86)	MNNIIQHMQLGV.GGPGQMDLDPQG
  967-  988 (22.63/ 9.91)	LDNAAAAAVVGMdGGQTMGGIG...
  999- 1022 (39.20/22.53)	IDDVLNAADMAV.GNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.36|      69|      72|     181|     252|       3
---------------------------------------------------------------------------
  181-  252 (95.41/76.99)	SL..GILLAALSGTTKGLEVLSADSQEALKVKLGQALSAYlPIcVEVSLPLrNRL.DSLQKEFN.LYGETPAKPLD
  254-  326 (100.95/66.48)	SMmeGVNVNALQFEASVMDGPMINSRAGLFVYINAMLVGR.PL.VDDSMLL.NYLsNRYGGHYEvLIEETITAAFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.03|      24|     211|     661|     686|       5
---------------------------------------------------------------------------
  661-  686 (42.70/29.02)	PFLlpSLVLALNWLGNHIWE.TEGDPS
  875-  899 (39.33/20.49)	PIL..TLRSALNLLHDNIPKiSEKDPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.17|      29|      64|     339|     368|       6
---------------------------------------------------------------------------
  339-  368 (47.29/36.67)	RSMFLFrSFLVNKL.P.AFFAAMLA.ASMVTLP
  404-  435 (40.89/26.14)	RQEFLF.ACASHKLiPeSSIERLLGeNPMQTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     227.12|      55|     622|     104|     160|       8
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  104-  158 (90.30/53.59)	KKS.RSCYT...LMTDIRV....VQDAM...LSV.STGSVPKSFSEAIS......IFTAIIDWIQAVVAWNSS
  725-  789 (70.57/39.55)	KDV.RARHP...SRTDIKP....ILDALepcLSFeRSGSCHRSELDSWTshspggLLGSIRSAFQSLVLWSAS
  798-  860 (66.25/38.70)	SYThRQLVTgvlLLGATRVlgalVEELK...LQT.ETGSGDIALDIAAT......LICAPMAEYFAIDQNNHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11282 with Med5 domain of Kingdom Fungi
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