<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11281

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVIDGFSQIYWRIYTEEPGITNIPGESPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLCLWTFSSTPGFEALASVAASRGKDDTGRLLVGSTTLKVSSSGSVSSSDLVKNLSAEPQHATGAAGPQRPSAPTPFVTIYASFISALMGTLSLQLIQQIGAVPLGSRTLLTLDERGLHETVGYGSGSLAFAPALTTLQVQLISAGKLTVALQTVPQPGLLRLCNPEDSPESHDVPPGTDLWLSPSGSIARLVTTKLAQRVGSSPYPYSIGGVGSDKSDPVNRKQWMANVLGWLANFGLPVNGIGEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSASSDSYGEMESVCAVIDNPLEFAERWHVLEKPNLNETSPKPLSIVQETETKDQDAPTPDTAGLPEGLESLSRASEYPDLQTAGLVYPTPPDGATTAGLNPTTVSSDAVSEDLYNGSAFPQQTRQISFGQPHNKDRSAMDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDEPGFDRMDEADHPDPMHEMPDFAVTEQLETQPTPAEHTFPGFVQEAVEDQRFEPEADKMDVATETQSEQPPHEKDVPLPSPQEDNVGTISPPLSPVEVKKFLFPEPQAESHPSPQQGQMPGYYKPIHFKQGISSWDRKYSTEGKFWFKMRGKDLIENTTTTSSDIPTIGLPRHTTSKRIAGVNPSNEHGSPLDDIYQEATSDSELSDAASIDDVESEAESDLSPATYPTRKRKRSLSNSGTSLALSPEKTSMNAEQDTATQRPEDSVFLGNFLSTFSDWSLTGYFSLSQNQTFPALLQKELQVQIAQILVDQITQSSLDHKYDGTVGLPGCGNEAHSPQSVDDESFMGGLERLDLNSFVSLQDPVALSPTTQARQSSQRRDTSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTATEAADTFLDRLGLVYSGCNLGNHDRGNGSNLFSRGMGSWDIDLSHTRYSSIMQSLKTICEDLGTALLQSPPGKDNNLVVYIVNPFAHAAALVDICSAFWSLFQRYVADADRQQARQLNELVLQIIPFDFLMANESLVVPPQAEYLNLALEVYSRCPPKSPHSSLVNGAPPMLLAEPLPKVINFKLSSEKTSPLQEGRCLHIACSRSQDQRWMSVAWSDNTGALQRTMSYCLRFRNSSAVRSIAEVRGEIWGATKDIMDRTQARWRVIVANTDPVDQEEVDTWTSLTEQYNKSRSANIELTILSVGTTPDLTLEPPFLPLPMSAVNPLASTTPIATPNPSISSPDQISTAPTPPSAANVPLNAPTPTDTNPEIESESLLMDICDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGVYTMGANIIYTRRSSASYDAVLREILGMYRDLATLARARGTRAVQQGTLPWHIATVVKAQALLSYAL
Length1482
PositionKinase
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.374
Instability index51.95
Isoelectric point4.88
Molecular weight161756.04
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11281
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     726.06|     173|     181|     384|     563|       1
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   76-  234 (172.92/77.37)	............WTFSSTPGF.....EAL.....ASVAASRGKD......DTGRLLVGSTT.L.KVSSSGSVSSSDLVknLSAEPQ...HATgAAGpqrpSAPTpfvTIYASFISALMGTLSlQLIQQIGAVPLGSR.TllT..LDE.RGLHETVGYG.SGSLAFAPAL..TTLQVQLI.........SAGKLTVALQTVPQPGLLRL
  236-  361 (152.74/68.90)	........................................NPED....SPESHDVPPGTDLwLSPSGSIARLVTTKLAqrVGSSPY...PYS.IGG....VG.....SDKSDPVNRKQWMAN.VLGWLA...NFGLP.V..NgiGED.SWVEVEV.WEPFYSRLAGE.TWRPND.....GGLSTLPL.KRILWPAIYCF.........
  384-  561 (276.65/149.46)	NPL....EFAerWHVLEKPNLnETSPKPL.....SIVQETETKDQDApTPDTAGLPEGLES.LSRASEYPDLQTAGLV..YPTPPD...GAT.TAG....LNPT...TVSSDAVSEDLYNGS.AFPQQTRQISFGQP.H..N..KDR.SAMDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFgAKGITDADFSFFDEPGFDRM
  568-  690 (123.76/54.52)	DPMhempDFA....VTEQ..L.ETQPTPAehtfpGFVQEA.VEDQRF.EPEADKMDVATET....QSEQPP.HEKDVP..LPSPQEdnvGTI.SPP....LSPV...EVKKFLFPEPQAESH.PSPQQGQMPGYYKPiH..F..KQGiSSWD........................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.79|      14|      29|    1179|    1192|       3
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 1179- 1192 (26.54/18.42)	SEKTSPLQE..GRCLH
 1209- 1224 (21.25/13.06)	SDNTGALQRtmSYCLR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.22|      77|     176|    1091|    1177|       4
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 1092- 1177 (109.90/77.85)	SLFQRYvaDADRQQARQLNELVLQIIPfDFLMANESLVVPPQAeyLNlalEVYSRCPPKSPHSSlVNGAPPMLLAEPLPKVINFKL
 1276- 1352 (131.32/63.37)	SLTEQY..NKSRSANIELTILSVGTTP.DLTLEPPFLPLPMSA..VN...PLASTTPIATPNPS.ISSPDQISTAPTPPSAANVPL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.54|      32|     248|     704|     738|       7
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  704-  738 (53.66/38.25)	RGKDLIEnttTTSSDIP...TIGL.PRHTTSKRIA.GVNP
  953-  989 (48.88/27.28)	RGKDFLE...TLPPAIPfweTFGLgPAHGQKDILAyCIHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.01|      15|     180|     744|     760|      10
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  744-  760 (22.64/15.74)	SPLDDIYQEATSDseLS
  763-  777 (25.37/11.92)	ASIDDVESEAESD..LS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.98|      13|     121|     798|     810|      12
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  779-  794 (17.24/ 7.36)	ATYPtrkRKRSLSNSG
  798-  810 (21.74/11.13)	ALSP...EKTSMNAEQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11281 with Med13 domain of Kingdom Fungi
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