<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11279

Description Uncharacterized protein
SequenceMIPHPSAGVQPWSRSMRAPNNGLGRVEAFQALSQSEPQSEKPPMPVPSLLPRQPAVIDLTTISADAQESEPPAKRLKLDVTSGAFAATGSPALVSGGEARTTPGTATAKPQSLTWRGRPAWSFQALLSETTGAVEVKDDDATAHGKTSSSPPPLPLLPWKYTPQQMPANDAPKIAEIAPVKEVKTTPYRIEVPTIAPKIKGEKVADFSPWTGNHPEDVLNEHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNMVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGVRGKVLLDQCLGKWIPVPRAIWLARCVGANEIRAFKRKGTSGALALGLESKWVRDWTATVQQFLDGVVGICGAADWKVKMTYAVSLTSRLFFERLLDHDQYLSWFLLSLENASLNTIPVWLLMLGIYWSNIMRYRKRGRKLAEVLLEKLRQIKNSGHHETLQPLIDRLSRCIRRLVLEHTSSLILPNSWTTYKDLISSCLNLKETPDQTMFHNLVERNSRVQLSKSQQEAKVRLPQQKIISLFDSLRSAHDVSATASACLDAVDDKTILVSKLLEWAATPFRHGSRRVYTSVRILRKWKMSGLDIEIHILNFVAGLDSNSRLNMEHIYHIFSELVRSQTFSVGRYLQWLMAKGLAHSPASEDQVISSEIRLLIQLPSHRLPEHVRNLRNMLIDRAGFSLEEENSIIAKLQMSIAGRLPNIFGSERSGSLKTNLSLPADLTWAVRSEIGLWIRRGVAGHYRKPGRKYSNIPLLSDLGISALTPAEFCIIREVLEGFGDLSMLADVLKQATTCDNSIVLASVADTVNYHFDTFRVISAVHDLFKGLVESYVRLKRFGAPSLDLIFSLIELGLRVPSEFNTVALLRQDLARIENRAAVAAPSPLSDHISVSTGQIDSLFQEKLDQTLLSGGGMDESTMDTSFASLTKALQDGHKKLSANEICRYMAYLRTFHPKRFDAMLVRWVCGLLKSQTRLPMARILPPLIGVGCVTIHAFVTLVKKLLQSEKVVAVIPSVAGLKLDLFELLIPPKPDQSRLADMVTYRFRLAQQEFLAKYPEESLDIIRDAIPLIGSENTDAIYGSRRDDLTECATMLLRLLLTQNPERIVQGCLQKFIAQHTASTALLQKALDSLLGFDSDASDKTTFEAEKVIRMNNDFSLPFCQLKLQLLFNAEAAGQDNNGIVDVMFKAAVADIKSHKDHWYGLVSLMSHDAIQQIRERAERGFFSIPMFEENSDSLQSIETARLYLTMIEKLAPCIPEAGVPTIVPVLVEKMEFLLQKFVAMQANHAGTGDARPTNQASPSSERSLAFWFSALLRIVVIHRASFNTPGLAPRSQGLPEQTRLLISIFCISLARLPNRVLRLYPSADYFPQPKPVESYRPCPGILLQTHALDVAACLIDIFPDEARQQCARFLKEKCPPFLQFQNDARFLYLLGPIVDSSNPPQPTSLPSPAAGGSTPTPSGSLVYGQQTPQQSSTAVSSGLSAGLSEGVNCIASHLRVQYRGRAIGAHPVRPWELLEDAAPIVGMNDTALSLKYFDARRIRA
Length1577
PositionKinase
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.146
Instability index49.27
Isoelectric point9.15
Molecular weight175087.69
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11279
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.97|      82|     145|       5|      98|       1
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    5-   98 (127.32/94.52)	PSAGVQPWSRS.MRAPNNGLGRVEAFQALsqSEPQSEKPPMPVPSLLP..RQPAVIDLTTISADAQEseppakrlklDVTSGAFAATG..SPALVSGGE
  152-  238 (131.65/75.50)	PPLPLLPWKYTpQQMPANDAPKIAEIAPV..KEVKTTPYRIEVPTIAPkiKGEKVADFSPWTGNHPE..........DVLNEHTAKQGhyDRTQVSQNE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     524.88|     136|     314|     427|     566|       2
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  427-  566 (217.61/160.81)	SLENASL...NTIPVWLLM.LG..IYWSNIM....................................RYRKRGRKLAEV.LLEKLRQIKNSGhhetLQPLIDRLS...RCIRRLVLEHTSSLILPNSWTTYKDLISS.CLN...LKETPDQTMFH.NLVE.RNSRV.QLSKSQQEAKVRLPQ......QKIISLFD.SLR
  576-  707 (177.71/121.47)	...SACL...DAVDDKTIL.VSklLEWAAT.....................................PFRHGSRRVYTS..VRILRKWKMSG....LDIEIHILN...FVA...GLDSNSRLNMEHIYHIFSELVRSqTFS...VGRYLQWLMAK.GLAHsPASED.QVISSEIRLLIQLPS......HRLPEHVR.NLR
  712-  890 (129.56/86.25)	DRAGFSLeeeNSIIAKLQMsIA..GRLPNIFgsersgslktnlslpadltwavrseiglwirrgvagHYRKPGRKYSNIpLLSD............LG..ISALTpaeFCIIREVLEGFGDLSMLAD..VLKQ.ATT.CDNsivLASVADTVNYHfDTFR.VISAVhDLFKGLVESYVRLKRfgapslDLIFSLIElGLR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.55|      34|     747|     741|     774|       7
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  741-  774 (60.01/38.15)	GS..ERSGSLKTNLSLPADLTWAVRSEIGLWIRRGV
 1489- 1524 (53.53/33.17)	GStpTPSGSLVYGQQTPQQSSTAVSSGLSAGLSEGV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11279 with Med12 domain of Kingdom Fungi
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