<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11277

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMEDGINVDDLFGEPASLELGLPSTTSTKGLAERLDEMRLLGCCQKIAWSKLGCIAYVAQDPSKVHVRYLQCQPTDGKWTLSDETPLLPVTEAHGGTALVHLSWNESGSELAVVDLSGRLSIYSIPIALNSVNGLRPPSFEPDDSAQIVGMLWLNTQRSVHAFYQAAKVQGRWAYSPYRRRPIGPFHPANKAALVYITRSGLIKLLYQNPDGKWAEISAELKNTSYSDRMLTHAALVATQTGILVATYSACQKICVYRVQINWNPPQYDPAQQPKQTPPQFPVPSFRFAHCKVETSCNVPGPARNNGDPSDNIHQPLPNSLYCLTRLDVILPTSDNAAGSSATPWIVATFSILPQIAPDHPHQQGPSSIIVRWQLESAPITLHPKFDEVTTKRNSMQMKAKAVLNRLDDIFCDRYVVSIDHIEYANVLAVTYDDSSISFYDPKTMAAFNGVDDANTVTSLAQAGFHYSPDTPGLHLSFSPSACAAVMLDSSGHVQLRVMEHSYGADNGLYDENKFSAAIASLTLAFCRGCGSEVNTDDILLILIRQLSSDAQTSFINEVYRALPINCNFTVEQDKLMNHPYIPRCLSIQAALGNKGKNHQRGFASSVSWFILQLRHASILYPFFFQYNKGIQAEPHDPDVLRMVLGNTKWALDFSLYILHELFNLADEFEDVSSDQEAFNQKLKTTNSLSLIILLSSMSRAFLRFICRGLRGIHAGYANAPLTGDARVYYAEICQAVETSPAAIDVYEKFLAGVDSAVRHAYHGAGFGDAERPGPEKELLVSARIPPVLVTAVSTILRQTIPSLRSDVNRMDIYMRDYSWLGVDSDRRTELYRRTRGLDIIKKIPIRLTPATNGAAQPSPGETKSKDGNAATGVAAGQPLRRRCVRCCEVSEGSYPPRSVLAFRMIFKLGHLRACICCGMWILESGSGSSEVGKPMGA
Length941
PositionTail
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.09
Grand average of hydropathy-0.155
Instability index41.00
Isoelectric point6.68
Molecular weight103732.08
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11277
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.95|      16|     205|      47|      77|       1
---------------------------------------------------------------------------
   47-   77 (17.15/44.58)	CQKIawsklgCIaYVAQ........DPSKvhvrylqcQP
  254-  277 (27.79/14.81)	CQKI......CV.YRVQinwnppqyDPAQ........QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.15|      33|      40|     139|     177|       2
---------------------------------------------------------------------------
  139-  177 (49.68/51.14)	RP..PsFEPDDSAQIVgmlWLNTQRSVHAFYQAAkvQGRWA
  184-  218 (57.47/37.48)	RPigP.FHPANKAALV...YITRSGLIKLLYQNP..DGKWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.86|      44|     300|     427|     476|       3
---------------------------------------------------------------------------
  427-  476 (61.04/62.74)	YANV.LAVTYDDSSISFYDpKTMAafnGVDDAnTVTSLAQAGFHySPDTPG
  733-  777 (74.82/49.37)	YAEIcQAVETSPAAIDVYE.KFLA...GVDSA.VRHAYHGAGFG.DAERPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.78|      35|     371|     104|     138|       4
---------------------------------------------------------------------------
  104-  138 (58.87/45.03)	HLSWNESGSELAVVDLSGRLSIYSIPIALNSVNGL
  478-  512 (61.91/47.79)	HLSFSPSACAAVMLDSSGHVQLRVMEHSYGADNGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.77|      17|     177|     516|     532|       6
---------------------------------------------------------------------------
  516-  532 (31.28/18.09)	NKFSAAI..ASLTLAF....CRG
  690-  712 (21.49/10.41)	NSLSLIIllSSMSRAFlrfiCRG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11277 with Med16 domain of Kingdom Fungi
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