<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11276

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDTANIGGQIQGSPNDSQNGVSYSAGEKAPMKGSAVVQNGSLYATGLEKGSAYRTDASTVTPVLAKTRELPELPHVTQGFFPFSILLNRSAQQCWNDLLDLITELAEIQVAPNDPGFASVPIVGKPPGNQSSENIQKKLRVLEFSHAKRADFIKLLVLSQWGRQAADVSKLIDIQNFIRTRHQAYTGALQWIGEMKKDLVRAQVANPDIRTSLEVLSKGRVASMLTLGYKPPKLLTPRRALRKLQKINRLLCTRLALHDELPPSFQTYSIHDGRVTFIVPTEFELDLSIGEGSGLSQFFFVDIRFLFRPSSPIPKGRIFNELESKVNDVLQTRGLPGCFDLLHNLVLTNKINVLFKQATEMARGLWTDVLRIELLHRTVVVHYWARKPGSKSWLEIGINSGRRGSIHGSPVPPYLGLRWIKDGEEVNSGLIDFDTANISMERLLRSVIALHVSHTVSSAYHSISQSLLYSTSTLSLRAQLTTTEPGNCLLDVQLTETRYLRVSVEPMSGANVFSTTPNILERPDNDRLADKPAVDDIVTRVARLRCIAAIEEVECYLQMLGFDVINPRILNIDVRRVFPLNVLRFSFFSHKSWERNWIVAATSSMDGDNWWLVQLRLGVVAKRHSAYDVNVGSRPTFRLAQVVSNTFISSRLEKSYMSFVNLGHSLSGILTIYANSRYLADLDAIKSCPPAHKLRIEAGFQIPDISLRYEPAKLPNALRLVLPAGIRQKGFIRETIRLTFLGINSQANLAIIGAYGRLNIPVKAFSALISKWDRSLVFQESHNGFAIRLLAPTGRPVIIGLVEDLQRLECVLSILDTLQRKKIEVTSISLSGISFNYGPERDLAARLEVDIKRNPSLSEADATELATRSDSIFRLQLGIKFDSTNPHRRIEGSLASSLNRTSAEASIETIAELLTSTLPLMRALDHIMDNTSRNESLKVQVTVRNAMTYVIHYPDANLHFQLVARIRSNRLVWVLRNVNSSESGSDQVNSMSKVQQSLYDSKGDGWRGLGNGVIAQVDRVGNILGELHRCIAASVPNPSLNKAGTRELSTVTPTQATALSEVASGVATKPVRQDSSRLAHLQERTTQHSASVASSTADVIMID
Length1108
PositionTail
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.117
Instability index44.16
Isoelectric point9.41
Molecular weight122781.28
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11276
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1102.20|     372|     434|      69|     496|       1
---------------------------------------------------------------------------
   69-  484 (551.07/471.99)	LAKTRELPELPHVTQGFFPFSI...LLNRSAQQCWND...LLDLITELAEIQ.VAPNDPGFASVPIVGKPPGNQSSENIQKK....LRVLEFShakradFIKllvLSQWGRQ..AADVSKLiDIQNF.........IRTRHQAYTGAlqwIGEmkKDLVR.AQ.VANPDIRTSLEvlsKGRVaSMLTLGYKPPKLLTPRRALRKLQKINRLLCTRLALHDELPPSFQtysIHDGRVTF...IVPTEFELDLSigegSGLSQFFFV..DIRFLF.....RPSSPI..PKGRIfnELESKVNDVLQT...RGLpgCFDLLHNLVltnKINVLFKQATEMARGLWTDVLRIELLhrTVVVHYWARKPgskswLEIGINSGRRGSIHGSPvPPYLGLRWIKDGEEvNSGLIDFDTANISM..ERLLRsvIALHVSHTVSSAYHSISQSLLYSTSTLSLRAQ
  499-  911 (551.12/375.80)	LTETRYLRVSVEPMSGANVFSTtpnILERPDNDRLADkpaVDDIVTRVARLRcIAAIEEVECYLQMLGFDVINPRILNIDVRrvfpLNVLRFS......FFS...HKSWERNwiVAATSSM.DGDNWwlvqlrlgvVAKRHSAYDVN...VGS..RPTFRlAQvVSNTFISSRLE...KSYM.SFVNLGHSLSGILTIYANSRYLADLDAIKSCPPAHKLRIEAGFQ...IPDISLRYepaKLPNALRLVLP....AGIRQKGFIreTIRLTFlginsQANLAIigAYGRL..NIPVKAFSALISkwdRSL..VFQESHNGF...AIRLLAPTGRPVIIGLVEDLQRLECV..LSILDTLQRKK.....IEVTSISLSGISFNYGP.ERDLAARLEVDIKR.NPSLSEADATELATrsDSIFR..LQLGIKFDSTNPHRRIEGSLASSLNRTSAEAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.57|      15|      19|      23|      40|       2
---------------------------------------------------------------------------
   23-   40 (22.73/23.47)	QNGVSYSAGEKapmKGSA
   43-   57 (27.84/17.80)	QNGSLYATGLE...KGSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11276 with Med14 domain of Kingdom Fungi
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