<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11275

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSFPLPLRPLLEKRERPDTLPQEIAQINAQYGSFRDVTEESLRAKIAEEKNKDPWAEEDEAEKPTAEVDTTERMDQLYKRRAEITQFAMQAHMEALFALDFVSLLLSKHTPRQAELSMSAYLKQVAPLGSLNAEIVSPPPKSEAALQDIKTVSRGWRIQNFNAAASKLLRSATRLETEVASETKYWEEVLAVKNKGWKVCRLPRDRQALGVQYGFLEATPIFRDRGLAALRRADDGSLLLDKGLIPQKVRTVRVRVKTQGQFTGCSKVSWSLPDADSIEGRILQARDTVYEEELFHEMVREARIMGSQGVTTRQNLVQVPVSEEQEVLLDLVDVDQGEPADTEVLSNEHDTLADAVAHSIRILLAYAHRQNLRRRTQPPPPLTPKRRHVPEYQLLRPVMAYLQHTAHVRSLESFMGDIVRVLKAAGLRCGFTSAPFSSVRLPTVHASVPKVETLVKQFLMPFESTFTGNLLTPESSFCVKVRTNTVSPPSGTYFEITVNLPHHPEVKPPSRIGLQAEAAAALAHFMLLDIVTTISSKGAKSPGGNDAGKGVLSWEAAYAHHGELRALSSLGNNKKMKVSLSREELTVETYPLRGVDVSGRAEKGKSANSRAQSWRADSSESRPSLMEFVEEVSQDRP
Length639
PositionHead
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy-0.419
Instability index48.11
Isoelectric point7.28
Molecular weight71250.22
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11275
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     346.07|     114|     273|      56|     186|       2
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   56-  186 (170.66/139.13)	PWAEE..........DEAEKPTAEVDTTERmDQLYKRRAE.ITQFAMQAHMEALFALDFVSLLLS...KHTPRQAEL.SMSAYLKQVAPLGSLnaeivspppksEAALQDIKTVSR..GWRIqNFNAAASkllrSATRLETEVASETK
  322-  452 (175.41/106.85)	PVSEEqevlldlvdvDQGEPADTEVLSNEH.DTLADAVAHsIRILLAYAHRQNLRRRTQPPPPLTpkrRHVPEYQLLrPVMAYLQHTAHVRSL...........ESFMGDIVRVLKaaGLRC.GFTSAPF....SSVRLPTVHASVPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.20|      17|      19|     488|     504|       5
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  488-  504 (33.17/26.18)	VSPPS..GTYFEITVNLPH
  508-  526 (25.03/17.62)	VKPPSriGLQAEAAAALAH
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.00|      24|     180|      22|      45|       7
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   22-   45 (42.46/25.51)	LPQEIAQINAQYG......SFRDVTEESLR
  204-  233 (36.54/21.09)	LPRDRQALGVQYGfleatpIFRDRGLAALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.09|      25|      26|     543|     567|       8
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  543-  567 (46.06/24.44)	SPGGNDAGKGVLSWEAAYAHHGELR
  571-  595 (42.03/21.80)	SLGNNKKMKVSLSREELTVETYPLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11275 with Med17 domain of Kingdom Fungi
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