Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSDSFPLPLRPLLEKRERPDTLPQEIAQINAQYGSFRDVTEESLRAKIAEEKNKDPWAEEDEAEKPTAEVDTTERMDQLYKRRAEITQFAMQAHMEALFALDFVSLLLSKHTPRQAELSMSAYLKQVAPLGSLNAEIVSPPPKSEAALQDIKTVSRGWRIQNFNAAASKLLRSATRLETEVASETKYWEEVLAVKNKGWKVCRLPRDRQALGVQYGFLEATPIFRDRGLAALRRADDGSLLLDKGLIPQKVRTVRVRVKTQGQFTGCSKVSWSLPDADSIEGRILQARDTVYEEELFHEMVREARIMGSQGVTTRQNLVQVPVSEEQEVLLDLVDVDQGEPADTEVLSNEHDTLADAVAHSIRILLAYAHRQNLRRRTQPPPPLTPKRRHVPEYQLLRPVMAYLQHTAHVRSLESFMGDIVRVLKAAGLRCGFTSAPFSSVRLPTVHASVPKVETLVKQFLMPFESTFTGNLLTPESSFCVKVRTNTVSPPSGTYFEITVNLPHHPEVKPPSRIGLQAEAAAALAHFMLLDIVTTISSKGAKSPGGNDAGKGVLSWEAAYAHHGELRALSSLGNNKKMKVSLSREELTVETYPLRGVDVSGRAEKGKSANSRAQSWRADSSESRPSLMEFVEEVSQDRP |
Length | 639 |
Position | Head |
Organism | Aspergillus aculeatus ATCC 16872 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.419 |
Instability index | 48.11 |
Isoelectric point | 7.28 |
Molecular weight | 71250.22 |
Publications | PubMed=28196534 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11275 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 346.07| 114| 273| 56| 186| 2 --------------------------------------------------------------------------- 56- 186 (170.66/139.13) PWAEE..........DEAEKPTAEVDTTERmDQLYKRRAE.ITQFAMQAHMEALFALDFVSLLLS...KHTPRQAEL.SMSAYLKQVAPLGSLnaeivspppksEAALQDIKTVSR..GWRIqNFNAAASkllrSATRLETEVASETK 322- 452 (175.41/106.85) PVSEEqevlldlvdvDQGEPADTEVLSNEH.DTLADAVAHsIRILLAYAHRQNLRRRTQPPPPLTpkrRHVPEYQLLrPVMAYLQHTAHVRSL...........ESFMGDIVRVLKaaGLRC.GFTSAPF....SSVRLPTVHASVPK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 58.20| 17| 19| 488| 504| 5 --------------------------------------------------------------------------- 488- 504 (33.17/26.18) VSPPS..GTYFEITVNLPH 508- 526 (25.03/17.62) VKPPSriGLQAEAAAALAH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 79.00| 24| 180| 22| 45| 7 --------------------------------------------------------------------------- 22- 45 (42.46/25.51) LPQEIAQINAQYG......SFRDVTEESLR 204- 233 (36.54/21.09) LPRDRQALGVQYGfleatpIFRDRGLAALR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 88.09| 25| 26| 543| 567| 8 --------------------------------------------------------------------------- 543- 567 (46.06/24.44) SPGGNDAGKGVLSWEAAYAHHGELR 571- 595 (42.03/21.80) SLGNNKKMKVSLSREELTVETYPLR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) RAQSWRAD 2) SFPLPLRPLLEKRER 3) SLMEFVEEVSQDRP | 612 4 626 | 619 18 639 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab