<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11271

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMATAPESSLEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDPTSNNASLAIQANYNEAFRQFIETREAFEGRLATMQGLEFIVSYDPLQAAAQPDGRFAHEPSNIWVIRKQTRRKRAGQDDEVEVLSTYFVVGDCIYMAPSVASVIGNRILSAVTSLTSLLKTASTLPTFTPSHGHTYLPPSAKQPDSAAQAAGTAAAQQSKENTPMPDAPTKAPLVGSQVAQTGGSVYQDTRTLAESFSLLTRYGDEFMDENPLVGEPGSFLMSKAGDAAAGGMSRQGPNAGGGATAARVATPQVRVDTPGRGSEKGAATPSAGLEDSKSRKKKVKVGA
Length332
PositionHead
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.08
Grand average of hydropathy-0.352
Instability index49.24
Isoelectric point6.01
Molecular weight35323.11
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	PIRNR:PIRNR013286
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11271
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.03|      36|      38|     185|     220|       1
---------------------------------------------------------------------------
  185-  220 (59.29/31.94)	AKQPDS..AAQAAGTAAAQQSKENTPMPDAPTKAPLVG
  224-  259 (57.22/30.58)	AQTGGS..VYQDTRTLAESFSLLTRYGDEFMDENPLVG
  261-  291 (30.52/13.07)	...PGSflMSKAGDAAAGGMSRQGPNAGGGATAA....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      16|      39|     128|     143|       2
---------------------------------------------------------------------------
  128-  143 (30.29/19.48)	LSTYFVVGDCIYMAPS
  169-  184 (32.15/21.08)	LPTFTPSHGHTYLPPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11271 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEFMDENPLVGEPGSFLMSKAGDAAAGGMSRQGPNAGGGATAARVATPQVRVDTPGRGSEKGAATPSAGLEDSKSRKKKVKVGA
2) TPSHGHTYLPPSAKQPDSAAQAAGTAAAQQSKENTPMPDAPTKAPLVGSQVAQTGGSVY
249
173
332
231










Molecular Recognition Features






MoRF SequenceStartStop




1) ARVATPQVRVD
2) KGAATPSAGLEDSKSRKKKVKVGA
291
309
301
332