<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11269

Description Uncharacterized protein
SequenceMADILTQLQTCLDQLATQFYATLGYLTTYHDNSPATVPPPTQAQTAPAAPALAKIPKNSSAPPVPASAPLAAQQQSNQTQQQTPAEIPQPAQPGAAGAEDTTTGTAQDPALPPAPDSPRTFAARQRELARDLVLKEQQIEYLISVLPGIGSSEAEQEHRIRELEGELRRWEGVRGERMLQLKALRGRLEGVLGAMEVGIYGEREV
Length205
PositionMiddle
OrganismAspergillus aculeatus ATCC 16872
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.04
Grand average of hydropathy-0.479
Instability index62.07
Isoelectric point4.92
Molecular weight22037.50
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11269
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.52|      14|      16|      35|      50|       1
---------------------------------------------------------------------------
   35-   48 (25.72/ 6.02)	ATVPPPTQAQTAPA
   53-   66 (22.80/ 6.80)	AKIPKNSSAPPVPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.78|      22|      23|     156|     177|       2
---------------------------------------------------------------------------
  124-  137 (16.74/ 6.75)	...RQR.ELARDL......VLKEQ
  156-  177 (41.57/25.23)	QEHRIR.ELEGELRRWE.GVRGER
  180-  203 (28.48/15.49)	QLKALRgRLEGVLGAMEvGIYGER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.63|      17|      26|      72|      96|       3
---------------------------------------------------------------------------
   72-   95 (24.88/20.46)	AQQQSNQTQQqtpaeipQPAQPGA
   98-  114 (30.75/ 8.79)	AEDTTTGTAQ.......DPALPPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11269 with Med21 domain of Kingdom Fungi
Unable to open file!