<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11263

Description Mediator of RNA polymerase II transcription subunit 20
SequenceMPITGVFFIPSNPNSSTVLSTISERLHTVLSDEPIPIGRWALEHKLMRDTPSCLPASASQRPAQPRWMQFLSLSYHPFHGFVYASEADKSQFGGAAHAQPQAPGQQPQAQAPGAVPGAPPQQSQLQQQQPQSTPGPGTSTATATNSGMIMTTVPLPSSVALFQHFVYACQPFWSHRHTHAIPGGMVYDIGDFRVRIGDVRQTQPVARIRGTVVEVEWRGPSLLDSLMQNHPVTETQENGEDDDSGIDVGLGLIEEADVDAEFAATAGLIREFWGRLGVEGAREAILVPDVGKEVKEQLRRWKALQQEGKKDVHGHGVGEGNGQLLDEDPDPQAGVDVARQFMEIFRFNR
Length349
PositionHead
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.423
Instability index48.65
Isoelectric point5.35
Molecular weight38087.20
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364152
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11263
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      17|      20|      99|     118|       1
---------------------------------------------------------------------------
   95-  117 (22.14/14.89)	AahaQPQAPGQQPQAqAPGavPG
  118-  137 (30.11/11.38)	AppqQSQLQQQQPQS.TPG..PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.94|      64|      81|     180|     249|       3
---------------------------------------------------------------------------
  180-  248 (103.16/73.07)	AIPGGMVYdigDFRVRIG..DVRQTQPVARIRGTVVEV..EWRgpSLLD...SLMQNHPVTETQEN..GEDDD..SGIDV
  263-  337 (88.78/46.65)	AATAGLIR...EFWGRLGveGAREAILVPDVGKEVKEQlrRWK..ALQQegkKDVHGHGVGEGNGQllDEDPDpqAGVDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.66|       9|      25|      31|      40|       4
---------------------------------------------------------------------------
   31-   40 (15.18/ 9.49)	SDEPiPIGRW
   59-   67 (19.49/ 8.26)	SQRP.AQPRW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11263 with Med20 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGGAAHAQPQAPGQQPQAQAPGAVPGAPPQQSQLQQQQPQSTPGPGTSTATATNSGMI
92
149










Molecular Recognition Features






MoRF SequenceStartStop




NANANA