<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11261

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNVNVGGAGQEPGIHESKNGLSNPGGPGSSTELRNGTTHVNGVSGTASGQLWKTEALAASGEPPALVHITQGFFPFSMLVNRSVQQCWNDLSELIAELAEMQVPYQDQSSLSVTPHGKSSGNQTSANVQKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSQLIDLQGFIRTRHQAYAAALQWVGDMKRDLVMAQVANPDLKTALEVLSKGRVMAMSDLGYKPPKPLTAKRTLKKLQKLNKIISIRLTLHDQVPRAFQTYRVHDGRVTFSVPGEFELDLSVGEENKSSQFFFVDIRFLFSPSSAIPKGRVLNELDIRINDVLRDSGLTGCFDLLHSLVLTFKANVLFKQAIELARGLWSDVLRVELLHRTLIVQYWALKPGAKSWLEVGIKSGRRRGSHGNPRVPCLGLRWVRDGQEVDNADIEFNTQNLSMECVLRSVIALHVSHILSSVYTSISENSLFSTGTLSLCAQLSRMEPGDCQLDIQLTSSRRLRVTVEPMSGASVLSTTPSILDRFDSDRGPDKSLTDEIASRVARIRCFSAIEEIESDLRILGFETVNPRSLKVDIRRIFLSNIIRFTFFRHHLWEPNWLIAATSSMDSDNWWVIQLRPTLSANKHPTLGAQNTSMLRSAQVISSRFFTAQQHTSYAACADLGHCLTGILAIYANARFLVELQCIHFHPPLHKLQIETGLRTPDIFIRYEASNLPPALQIAQPAGLKKSYIKNTIRVAFHGIDPHKNIAILVAYGSLSMPVKSLGTLVSKWDPSIVFRQKGDGFAIRLLAPAGQVVIVDLIEKLQRLERILSIIESLQRKKMDVLSLSLSHIAFSYGPGKALRANINVSTSGPSPSADTDLAGIPSKTDSVSLQRLGISFDYPTPHRRIQESLTTSLNNASSEAGLDSFFELLTLTLPLLRALDQITVNQSHNEPLKAQITVRNAKTYQIHYPIAKFRFQLVTGQHLNRMTWILKDVSGTQDRSHQGQITGRLREKLYNAKGDGWRGLGTGMVADVDKVSNLILELDGCFSDSRSTIATPGHSAVGHGTRNVSQQQAVGQGGPRQTSKAGVPPSGGAPAVGAPGRKPEQKTSDDVIMID
Length1091
PositionTail
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.176
Instability index42.53
Isoelectric point9.39
Molecular weight120221.14
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.83|      25|     219|     769|     796|       1
---------------------------------------------------------------------------
  769-  796 (34.02/27.18)	FRQKGDGFaiRLLApAGQVVIVDLIEKL
  990- 1014 (46.81/25.68)	YNAKGDGW..RGLG.TGMVADVDKVSNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.33|      45|     269|     251|     301|       2
---------------------------------------------------------------------------
  251-  301 (65.86/51.81)	LHDQVprAFqtyRVHDGRvTFSVPGEFELDLSV.GEENKSSQFFFVDIRFLF
  479-  502 (28.25/ 9.96)	.......................PGDCQLDIQL.....TSSRRLRVTVEPMS
  527-  572 (70.23/37.88)	LTDEI..AS...RVARIR.CFSAIEEIESDLRIlGFETVNPRSLKVDIRRIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.15|      13|     641|      60|      76|       3
---------------------------------------------------------------------------
   60-   76 (17.34/23.50)	ASGEPPALvHITQgffP
  703-  715 (25.81/15.02)	ASNLPPAL.QIAQ...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.68|      38|     645|     201|     246|       4
---------------------------------------------------------------------------
  201-  238 (62.65/30.30)	PDLKTALE.VLSKGRVMAMSDLGYKPPKPLTAKRTLKKL
  847-  885 (59.03/27.87)	PSADTDLAgIPSKTDSVSLQRLGISFDYPTPHRRIQESL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11261 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDNVNVGGAGQEPGIHESKNGLSNPGGPGSSTELRNGTTHVNGVSGT
2) STIATPGHSAVGHGTRNVSQQQAVGQGGPRQTSKAGVPPSGGAPAVGAPGRKPEQKTSDDVIMID
1
1027
47
1091










Molecular Recognition Features






MoRF SequenceStartStop




NANANA