<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11260

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTITTTAPSPSSAEQWRLFLDQCLKHRIDANEFKNLSNILAARCSVSESVLVDVLCDVRAVGAAAGVKWDPLVPVYIDCLCKTERVKIPSVLAGLLKRSYILPQSQIQSSDESEKSKQQKKNGYTLMTDIRVIQDVMLAVSTGNSTPRTAAEAMEIFSAAVDWIQAVVAWHQQHQQTGGLMGSPDVVSLFESLGILLAALSGTTKGVDVLSSDNEGLKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFNLYGEPASKSLDMTMMDGMNVNALQFEASVMDGPVINSRAGLYVYINSMLVGRPLIDDNMLLSYLVNRYGGHYKALIEEVITASFDVLSNAMYRNESNRTMFIFRSFLVNKLPAFFATMLAASMVSIPMEICISNALGRLDPNTFPSFSQMFSMQGNTVLSDVRQEFLFACASHQLIPESSIERLLGENPMQAVPVGHVKDDLVSQIYANPERAEQLTNDIESTEGNANAIVGAVTEVIHQLCNQKESMTLKNICNSLSRRPQALDVILLFRSTKQILQPLCTLLDNWHWDSDQGENQPVYDEFGSILLLILNFKYRYDLKPYELGISSDDSFVLKLLDRGSCSQKLEDLTEKQNKDLGAWIGALFIAEGISEETMSNCSPQEFYLLVTTLFSQSLGACEAGKLEFETLKGGFEYLLEPFLLPSLVVALGWLGNRIWESESEPTIALKTLHSLVSPTSISGEAQAIHQTVLSMTARTLEEQLKDVRARHPSRTDIKPILDALEPHLSFQRTGGCHRTELESWSHSGNGGAGGLLGSVRNTFQSLVLWSTNPEISMAPPSYTHRQVVVGVRMLGASRVLRALEEELKLQTEAGSGDLALDVAAMIVSAPMMESFTADQMHYHPPENKDQSQQTKQQQAAANLRSPVLTLRDALSIRHQDVPRVSEKDPLRAEMIVRLYRRVNAVTAPTAQVPSLDVSNILGNMPVADQSSQPQAQPQSQTQQQSQQQQQQSQQAQSQEQQQQNQMDLDADAEDGDFSHMLDTAAAATGDGGGGMDGMDMGTGLDTSIDDVLNAADIAAVGNPEFLDLDMEGMF
Length1062
PositionTail
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.160
Instability index50.97
Isoelectric point4.82
Molecular weight116707.21
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP11260
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.44|      54|     299|     201|     258|       1
---------------------------------------------------------------------------
  201-  258 (84.09/73.40)	SGTTKGV.DVLSSDNEGLK.IKLGQALSAYL.PLCvevSLpLRN.RLDSLQKEFN.LYGEPAS
  498-  556 (76.35/53.51)	SMTLKNIcNSLSRRPQALDvILLFRSTKQILqPLC...TL.LDNwHWDSDQGENQpVYDEFGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.44|      36|     100|     848|     888|       2
---------------------------------------------------------------------------
  848-  886 (56.80/38.75)	LDVAAMIVSAPMMESFTADQMHyhpPENKDQSQQTKQQQ
  943-  978 (64.65/30.99)	LDVSNILGNMPVADQSSQPQAQ...PQSQTQQQSQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.53|      84|     100|     646|     733|       3
---------------------------------------------------------------------------
  646-  733 (131.73/110.19)	LGACEAgKLEFETLKGGFEYLLEPFLLPSLVVALGWLGNRIWESESeptIALKTLHSLVS..PTSISGEAQAIHQTVL..SMTARTLEEQLK
  749-  836 (137.80/100.90)	LDALEP.HLSFQRTGGCHRTELESWSHSGNGGAGGLLGSVRNTFQS...LVLWSTNPEISmaPPSYTHRQVVVGVRMLgaSRVLRALEEELK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     294.57|      93|     272|      87|     185|       4
---------------------------------------------------------------------------
   87-  185 (146.49/109.74)	KIPSVLAGLLKRSYI.LPQ........SQIQSSDESEKSKQQKKNGYTLMTDIRviQDVMLAVSTGNSTPRTAAEAMeifsAAVDWIQAVVAWHQQHQQTGGLMGSPD
  361-  462 (148.08/96.25)	KLPAFFATMLAASMVsIPMeicisnalGRLDPNTFPSFSQMFSMQGNTVLSDVR..QEFLFACASHQLIPESSIERL....LGENPMQAVPVGHVKDDLVSQIYANPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.69|      17|      18|     279|     296|       5
---------------------------------------------------------------------------
  279-  296 (25.94/20.03)	SVMDG.PVINSRAgLYVYI
  298-  315 (25.75/14.36)	SMLVGrPLIDDNM.LLSYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11260 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APTAQVPSLDVSNILGNMPVADQSSQPQAQPQSQTQQQSQQQQQQSQQAQSQEQQQQNQMDLDADAEDGDFSHMLDTAAAATGDGGGGMDGMDMGTGLDTSIDDVLNAADIAAVGNPEFLDLDMEGMF
2) FTADQMHYHPPENKDQSQQTKQQQAAANLR
935
863
1062
892










Molecular Recognition Features






MoRF SequenceStartStop




1) QMDLDADAED
993
1002