<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11257

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGNITNVHVIDGFSSLHWRIYTEEPGITNHPSEAPTNGHTVLKHLSRLKDLELRLRNLGCLVSCYPRRLGLWAFSPNSNFDSLAPLNQGNDGLNRLQVGSLTLKVSASGSVSSRELVRTLSTEPQAPNVNTVGSQRSQNVPNPPRRIEGYGTSAAIYASFISAVTGAISLQLMRRHGAIPLGSRTFFTAIEKDGYETRIANDSYTAIPSLSTLHIQLMSGGKLTVALQTIAQHGMSRLQSPKNDPDELRDTQPGLDIWLSPSGTVARLVSFNASTQDSISPNPSGSNGTSGLAAAKRSQWKQSVLEWLGNFGLLVDSHEELWIEVEVWEPFYSRLAGEIFRQSEEGPTAFPLKRILWPARYCFRRTKSIALDASYGKQDSCHLADSPLGLAEEWHVTGNFVHDEATSIAPSGGFQDQPMRDSEISPSKAEFPEPMKSLSRIAQYPDLQATNLVYPTPPDGATAISSDMFADQPDLPLPQTQHRDQQKPKQASFKEQAGSGITMDFGPSAGLTVGSGLYDMNGDDDLFGEMNDRDFGTRGITDADFSFFDDPDFGDMGGAPATDHIQSTPNIVETNLEEDDEQPSPDVPLPDNHAVTTAEEMNVPQTNVAEQEAEIPSKREISEIRMSSPREESSQPISPPLSPVEVKKILFSGPDDGDQSNVKRERKQSHFTPVSFKQNIGDWNQKYGAEGRFWFSAPGTSTAMESVNPPSDIPTIGLPRRSGKAAVKFDNPTKVTGERDALSGGPKGSLHSTSDSSSISSDDDDSDEVMSEREPSPVNLTRKRKRAQSNTSGSITQVLDNPLIENAQLVSANKAENSTFLGNLLSTFSDWSLLGYFSVSQNQHPPTISQKDEQIQVAQLLVDQITQSSLDHVFDGQVGLSGLDNEMYPLRNILEDTVFTDEVDRLDLKSYASLQNGSSPPSSEGLTPRQLPQRKEAAKGAISKLLPPHLRIRRGKGYLEALPPAVSFWETFDLEPAHGPKDISAYCIHPRATTDAADAFLERLGLLYSACNLGNHARGDMCFERGLGSWNTETSNYLSTVQSLRDLCEELGNALSGSQPRTENFVVYVINPFTHAAALADICAAFWQLFQKYIMGTDKQQVGKLNELVLQIIPISFVMSPESIVVPSQSDYLSLALEVYSRCPPKDSESNLVHCAPPVLLTESAPKAISFKLVPERLSPLQDGKSLHIACSRSLDQRWITVAWSDNTGALQRMMSYCLRYRNSGTARGISDVRNEIWGTTQTIMDRIKARWRIIIVNTEPVDQDELDTWTNLAEQHNKSKPIPLELMILHVNAITDFSLEPPSLLIPTSVFNAQASSTPVATPGPIVASPDQYGNAPTPTNGGNAPMSATTPDFQPESESDFFLTDIRDESWNVILSHRLNSSPHLTEYRPALASGYLLRRKGPTDGDGVFATNVNLIHSQRPTSSHETLLKEILGMYHDLAILARARGTRCVQRNTLPWHIATAVRAQQLLSYVF
Length1481
PositionKinase
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.436
Instability index52.58
Isoelectric point5.20
Molecular weight162571.79
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11257
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.35|      45|      49|      33|      81|       1
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   33-   78 (78.57/45.42)	NHPSEAPTN.GHTVLKHLsRLKDLELRLRNLGCLVS.CYPRRLGLWAF
   83-  129 (64.78/37.38)	NFDSLAPLNqGNDGLNRL.QVGSLTLKVSASGSVSSrELVRTLSTEPQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.47|       9|      14|     943|     952|       2
---------------------------------------------------------------------------
  943-  952 (12.62/10.45)	KGAIsKLLPP
  960-  968 (17.85/ 9.65)	KGYL.EALPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.33|      32|     430|     982|    1038|       3
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 1006- 1038 (56.24/70.13)	ERLGLLYSACNLGnHARGDMCFERGLGSWNTET
 1438- 1469 (59.09/24.97)	EILGMYHDLAILA.RARGTRCVQRNTLPWHIAT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.57|      32|      51|     563|     594|       4
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  563-  594 (55.72/33.98)	APATDHIQSTPNIVETNLEEDDEQPSPDVPLP
  613-  644 (53.85/32.56)	AEQEAEIPSKREISEIRMSSPREESSQPISPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.37|      26|      51|     462|     488|       5
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  407-  425 (23.71/ 8.40)	.DEATSIApS...GGFQDQP........MRD
  462-  488 (45.86/27.53)	PDGATAIS.S...DMFADQPDLpLPQTQHRD
  511-  538 (37.79/17.63)	PSAGLTVG.SglyDMNGDD.DL.FGEMNDRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.43|      81|     433|     262|     404|       6
---------------------------------------------------------------------------
  145-  262 (123.51/100.10)	PNPPRRIEGYGTSAA...............................IYASFISAVTGAISLQLMRRHGAIPLgSRTFFTAIEKDGYETRIAND.SYTaipslstlhiqlmsggkltvalqtiaqhgmsrlqspKNDPDELRDTQPGL.DIW
  285-  398 (125.92/134.35)	PNPSGSNGTSGLAAAkrsqwkqsvlewlgnfgllvdsheelwieveVWEPFYSRLAGEIFRQSEEGPTAFPL.KRILWPARYCFRRTKSIALDaSYG....................................KQDSCHLADSPLGLaEEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.79|      29|     432|     705|     755|       7
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  705-  736 (44.30/59.98)	STAMESVNPPSdiPtIGLPRR........SGKAAVKFDNP
  770-  806 (44.49/15.67)	SDEVMSEREPS..P.VNLTRKrkraqsntSGSITQVLDNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.27|      33|     434|     846|     881|       8
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  846-  881 (53.24/42.72)	NQHPPTisqKDEQIQVAQLLVDQITQSSLD........HVFDGQ
 1279- 1319 (50.03/32.04)	EQHNKS...KPIPLELMILHVNAITDFSLEppslliptSVFNAQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11257 with Med13 domain of Kingdom Fungi
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