<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11255

Description Uncharacterized protein
SequenceMIPLSSAGAQPRGHHPLRAVNTASGQPKTFQALAQSDANLPTPVPQAQFRQQPTVIDLTSGEDAQEREPPAKRPRLDIPTGRSSGTASPVPGVGGGDLRSAPGGPTTPRPPSTASWRGRPVWSFQSLVSETPGVGDVYGDNAAALSQGGKPASPPPLPTPPWRFVPQRPLSGRSRDSSPVKAVQTTPYRIETPPAAPALKGEKVADFSPWTGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFASAFEKRQNHNTVATSSTFKPPPRVTLTDNKRESWLRDLANPAVPLRRLSRTIPHGIRGKVLLDQCLGKWVPVARAVWLAKCVGANEIRAFKRKGTSGPLAVGLEAKWVRDWTVNVQQFLETVIAACGTADWKMKMTYAVSLTARLFHENLLDHDHYTGWFLLCLEAAPLKTLPVWLLMLGIYWDSIMRYRKRGRRLAELLLAKLTQVSKSEHAGALKPLIDRLSLYVKRLVREHTSSAILPTSWATYRNLVSSSLDLDDKVDRAIFQNIAERNIRVQRPMRCQSAAHRSGQQQQQHIIRLFDSIRTAHDISSVSVACLDTFEDRDTLIYKLLEWTATPFRHGLRRVYIAVRLLRKWKMACIDVDSHILGFLSDSPKANENMDMVYHAISELVRSQTFSVGRYLQWLMAKGVSRDSLSDHNIIPGGVGLLSHLPVSHLPEHVRNLRDTLLVRVGIASSEEATTIAQVKSFIATRLPRVFGGYEADSTFEPAYQSLTWAVKSEIGQWIRHAVAQHCRDPTRSISGVPFLTDLKVSSLTPDEFYEIRGLLESFGDISMLADVVKQAASSDDNIVLASAADTVNYHCDSFNVIGAATDLFRRLVDAYSLLKRLGTADLDLIYSLIELGLQLPNEYNTVAILRQDLSRIENRSAQAAPSPLSDHIPDTVYETDPSFLEKLDQFLSSGSGMDEPTMDAIFDALVKVLDMGDGQTKLSANDACRYLAHLRPFHPKPFDARLVRWVCGALKMSDRTEFFKSLPPLIGVGCVTIQAFLSLVKKLLQVKPASVPNVDELQMDLFELLAPSTTQDGCRDLVTYRFYLAQHEFRTKHLEETLEVIRGAVASTEQNKGPSPDPTQNHLETSMVILLCDLLTNEPGNAAQQSMQKLTDQQPAFRVALQNALDRLLGLDSASQAENNLSEAERVISMTSDFSLPFCQLKLQMLFNVASGEEVKNGVVDVMFKMAVEDSRSKRSNWVGLVALMNQDAVRQIRERAEKEFLSVPMLPLEASADENGFSSVNYTNAIETARIYLMIIEELAYSVPESGVPSIAPVLVEKMDLLLNKFVVMQTNFTNFAENRNDTSGEGQQNTAGSNFERGLAFWFSVLLRMVVIHRSAFTSSTKPTSLQEQTRILISIFSIALARFPNSLLRLFPTADYFPHPHQPDDYRPCPGILLQTHALDVAASLIDIFPDEARHHCARFLKEKCPPFAQFQNDSRFLYLLGPLPGYGASANSAQPASLPSPAASGSTPTPSQTQAPAAAAAPSPSLSAGLPSAERPNCMSNSLRLQHRGRIVGAYHIRPWELLEDAAPLAGVNDTAISLRYFDARRIRA
Length1589
PositionKinase
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.238
Instability index48.19
Isoelectric point8.32
Molecular weight175794.29
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11255
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.15|      13|      15|     317|     331|       1
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  317-  331 (19.39/20.42)	PhgIRGKVLLDQCLG
  335-  347 (24.76/16.30)	P..VARAVWLAKCVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     184.55|      38|      39|      57|      94|       2
---------------------------------------------------------------------------
   57-   88 (43.30/16.13)	.................DLTS..GEDAQE......REPPAKRPRLDIPTGRSSGTAS
   89-  129 (55.74/22.91)	PVPGVG.........ggDLRSapGGPTTP......R.PPSTASWRGRPVWSFQSLVS
  130-  178 (56.38/23.26)	ETPGVGdvygdnaaalsQGGK..PASPPP......LPTPPWRFVPQRPLSGRSRDSS
  179-  208 (29.12/ 8.39)	PVKAVQ.......................ttpyriETPPAA.PAL...KGEKVADFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.93|      43|      98|     668|     717|       3
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  668-  717 (68.16/51.33)	QWLmakgvsRDSLSDHNIIP....GGVGLLSHLPVSHL.PEHVRNLRDtLLVRVG
  768-  815 (70.77/38.17)	QWI......RHAVAQHCRDPtrsiSGVPFLTDLKVSSLtPDEFYEIRG.LLESFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.11|      18|      18|    1152|    1169|       4
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 1138- 1155 (26.16/17.07)	AAQQSMQKLTDQQPAFRV
 1156- 1173 (24.95/15.89)	ALQNALDRLLGLDSASQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.54|      11|      16|       7|      17|       6
---------------------------------------------------------------------------
    7-   17 (22.08/11.75)	AGAQPRGHHPL
   23-   33 (18.46/ 8.53)	ASGQPKTFQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.86|      10|      15|     220|     229|       7
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  220-  229 (19.38/12.42)	NE.QTAKQGYY
  237-  247 (14.47/ 7.25)	NEsNTARPSLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.92|      65|      98|     934|    1005|       9
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  934- 1005 (96.68/92.56)	SFLEKLDQFL....SSGSGMDEPTMDaIFDALVKVLDMgDGQTKLSandACR.YLAHlRPFHPKPFDARLvRWVCGA
 1031- 1100 (101.24/69.25)	AFLSLVKKLLqvkpASVPNVDELQMD.LFELLAPSTTQ.DGCRDLV...TYRfYLAQ.HEFRTKHLEETL.EVIRGA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11255 with Med12 domain of Kingdom Fungi
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