Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAHMQSSLSSLESKLNLLITSLTTSPTAAGAPAAASAVLDADDSLTSAVETLRQHQENYAKILRLRAEAENLEERVKGIVSDVETREKEIRTICGDAENDTDSEADDDSSDYDSDEDMDMSKSRSRIRMNKEVDYKLLLDFARRISKYNHQAAADAAAGIPAAQKLKDKRQQITEQDVAMTGVNGATETEEGAEPVSSVTKEATSWLDESANMTREIYMLPYPAEDRIRMGLMGQVQLAAAEGRPGFDSDNEVERLIREAEGQGAAEAIEPAQQGDEPRRVDEAAQAAAHAGSAATSGAKSGPAPAPKPKATLDLDLYDPEDDEM |
Length | 326 |
Position | Middle |
Organism | Aspergillus glaucus CBS 516.65 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.684 |
Instability index | 48.19 |
Isoelectric point | 4.44 |
Molecular weight | 35204.23 |
Publications | PubMed=28196534 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11253 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 242.38| 78| 81| 145| 225| 1 --------------------------------------------------------------------------- 145- 225 (122.74/73.30) RIS.KYNHQAAADAAAGIPAAQKLKDKRQQITEQDvaMTGVNGATE.TEEGAEPvSSVTKEATSWLDESANMTREIYMLPYPA 228- 307 (119.64/63.44) RIRmGLMGQVQLAAAEGRPGFDSDNEVERLIREAE..GQGAAEAIEpAQQGDEP.RRVDEAAQAAAHAGSAATSGAKSGPAPA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IYMLPY 2) PRRVDEAAQAAAHAGSAATSGAKSGPAPAPKPKATLDLDLYDPEDDEM 3) VERLIREA | 218 279 254 | 223 326 261 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab