<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11252

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASSATFRVGFPSPSSPSVGYLKENDQPYISSDHFPQTPTSPPLMSVSAQSHATHFAPSQTSPRQATSQSADYSSLPSSDPMSSQVSQQPTLSSTTTSFPTPASSVSGHLVDADKSTGTGMQESGSTAMANADAALTQTPPQHTRTDHDRDMGGTDPGSGVRNSANTDAMEIDNNDNSGSSNNGGAASLENNGFSLNSLQREFTSAYHLCKSSHVVTGPDPSLDLVSLYGLGPAARSVARIDPVTGDKINRLRKSYEGKLKGLGLAGRNKPVKNEPSMPGSLRHLTMWPEEEWQNQKVFGKQIKVADMDSALQQLQMKAVKLEPGTVPNNDYWEDVLGHEKPSKHTGAGDSGKKTAAPSGGVRAPSQPNGSPASAELERSRPSRGHKRRYDDNSFIGYGEGYADDDDEGAFYSNSEGIGKKKRKKDHVPKVSTPLSERRGNGMFGIGAR
Length452
PositionHead
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.852
Instability index49.73
Isoelectric point6.68
Molecular weight48111.11
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11252
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.50|      33|      37|      38|      73|       1
---------------------------------------------------------------------------
   38-   73 (53.08/32.79)	FPQTPTSPPlMS..VSAQSHATHFAPSQTSPrqATSQS
   76-  110 (51.42/23.51)	YSSLPSSDP.MSsqVSQQPTLSSTTTSFPTP..ASSVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.50|      23|      38|     115|     137|       2
---------------------------------------------------------------------------
  115-  137 (37.93/18.45)	DADKSTGTGMQESGSTAMANADA
  150-  172 (40.58/20.25)	DHDRDMGGTDPGSGVRNSANTDA
  176-  194 (23.98/ 8.98)	DNNDNSGSS.NNGGAASLEN...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.55|      23|      38|     331|     353|       3
---------------------------------------------------------------------------
  331-  353 (44.34/26.45)	PNNDYWEDVLGHEKPSK.HTGAGD
  371-  394 (37.21/21.04)	PNGSPASAELERSRPSRgHKRRYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.48|      18|      31|     270|     290|       5
---------------------------------------------------------------------------
  270-  290 (28.03/21.10)	GRNKPVKNepsMPGSLRHLTM
  303-  320 (30.46/15.10)	GKQIKVAD...MDSALQQLQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11252 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDEGAFYSNSEGIGKKKRKKDHVPKVSTPLSERRGNGMFGIGAR
2) PNNDYWEDVLGHEKPSKHTGAGDSGKKTAAPSGGVRAPSQPNGSPASAELERSRPSRGHKRRYDDNSFIGYG
3) RASSATFRVGFPSPSSPSVGYLKENDQPYISSDHFPQTPTSPPLMSVSAQSHATHFAPSQTSPRQATSQSADYSSLPSSDPMSSQVSQQPTLSSTTTSFPTPASSVSGHLVDADKSTGTGMQESGSTAMANADAALTQTPPQHTRTDHDRDMGGTDPGSGVRNSANTDAMEIDNNDNSGSSNNGGAASLENNGFS
409
331
4
452
402
198










Molecular Recognition Features






MoRF SequenceStartStop




1) RKKDHV
2) SATFRVGFPS
3) SFIGYGEGYAD
4) SPSVGYLKENDQPYISSDHF
426
7
397
19
431
16
407
38