<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11247

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSSDAPGDSSATADSFTLPLRPLIEKRDRPDTLPVEIAQINAQWGSFRDVNEDELQAKIQEEKDKEGIEDEDEGEKSAGEVDSTERLEQLYKRRAEITQFALQAQMETMFALDFVSLLLSKHAPRQAETSMSAFLKQAVPLGSLNSEIVNPPPKPESAAQDPKAVSRGWRLQSFDAAANKLLKSASRLETEVASETRYWSEVLAVKDKGWKVSRLPRERQALGVQYGFLEATPIFRDRGLASLRRADDGSLILDKGLVPSKSRRIRVRVKVNDRITGCSKSTRSTADGEESIETRILQARDTVYEEELFHELVREARIMGGQGVTTRQNLIRFAVSEEQEIMLDLADTDLESFSEDTDVIDSHEDDVLADTIAHSTRILLSYAHRQNLHRRTQPPPPLSQKRRHTPEYQLLRPILAYLQHRSHVQWLESFIKDMYGVLKSAGVDCDHSANLFSSVNPQRKNHSLPRVEALVQGFLVPLESTVSGSLITPQSPFRVRIRTSLVSPPFGTNYDISMTMPQHPGIQPPARVGLRDEAAAIITHFLMLDVVSAISSYRPQPGVDGHLTWQAAYPHHGELLTVSPTFGEQKKKMKVTLARGEMTLDVSHVRAADGTSTHSQTWKADPTVPQQPGLMEFVADVSKQ
Length640
PositionHead
OrganismAspergillus glaucus CBS 516.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.504
Instability index50.45
Isoelectric point5.90
Molecular weight71558.84
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11247
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.48|      33|      36|     490|     522|       1
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  490-  522 (61.21/36.47)	QSPFRVRIR...TSLVSPPFGTN................................Y..DISMTMPQHPGI
  523-  559 (42.32/23.04)	QPPARVGLRdeaAAIITHFLMLD................................VvsAISSYRPQ.PGV
  566-  630 (40.95/22.07)	QAAYPHHGE...LLTVSPTFGEQkkkmkvtlargemtldvshvraadgtsthsqtW..KADPTVPQQPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.10|      26|      27|     183|     209|       2
---------------------------------------------------------------------------
  183-  209 (39.57/30.31)	KsASRLETE.VASETRY.WSEVLAV.KDKG
  211-  239 (32.53/19.63)	K.VSRLPRErQALGVQYgFLEATPIfRDRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.26|      21|      26|     124|     146|       5
---------------------------------------------------------------------------
  124-  146 (31.10/22.21)	PRQAETsmSAFLKQAVPLG.SLNS
  152-  173 (33.16/17.43)	PPKPES..AAQDPKAVSRGwRLQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.20|      30|     380|      17|      47|       6
---------------------------------------------------------------------------
   17-   47 (52.03/33.59)	TLPLRPLIEKRDR.PD...TLPVeIAQI....NAQW.GSF
  392-  430 (40.17/21.08)	TQPPPPLSQKRRHtPEyqlLRPI.LAYLqhrsHVQWlESF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11247 with Med17 domain of Kingdom Fungi
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