<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11245
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MPGVVMDNANIGGLRHGPGNTYLQDGSSHSRGGDTQFNGDANAQDGPVHVNGVEKNAGQNRTVEAVATNHASRVNKGPPELPHITQGFFPLAKLVNRSVQQCWNDLSDLITEMAEMQVNSHEFHPSPASTSGKSPGNQSPGNIRKKLRILEFSQAKRAEFIKLLVLSQWSRQAADVSKLIDIQNFIRTRHQAYMNALQWVGDMKRDLVQAQVANPDLKTALEVLSRGKVASMSDLGYKPPRPLTVRGTLRKLQKINRLIGARLVVQEDIPPPFRNYQVHDGRVTFVVPGEFELDLSIGEENEKSQFFFVDIHFLFSPSPPVLKGRLLNEIEMTINDVLQKSGLTGCFDLLHNLVLTNKVNILFKQATELARSSWSDGLRVELLHRTLVVQYWTLKPGAKSWLEIGIKSGHRKSDSESPGLPSLKFRWLRDGDEVPCEDIAFDAENLSMETVLRSVIALHVSQILSSAYSKIRQSSLFSTGVLSLCAHLTRTEPGDCQLDVQLTETRRLRVSIEPMSGMSILSATPTISDRFDMERNAERPSVEDIVSRVARLRCNAAIEEIESKVKMLGFEPLNPRAWKADIRRIFPSNVLRFTLFSHQLWGRDWIVAATSSMDGDSWWVGQLRPTVTAKSHPVPQASGRDQSVLRSAQVVADSFFPAHFDIDDAYLANLGHSLSGILAIHSNARYLSDLQSIKFHPPPHKLKIGPDLRVPDILVRYDVSTLPSAFRVVMPAKTKKKGLIRDTIRLAFHGVDPREKCAIMVAYGNLVDSTASLAPLISSWDRSLVFQKGGSGFAMRLLAPAGRPVIVSLLENLQKLECVLSVLESLQRKRVEIRTFSLSSISFVYGPERDLAASLNIHLSRSESLMELSPTELASRPESLFGLRLGIQFGLQNPHRRIQESLASSLNRSSTETGLETVIELLMLTLPLMRALDQLMSNPSYSGPLRLHVTVRNARTYQIHYPGDKARFQLVAASHQNRLVWVLKDANSQGETRNDDEATARLRQTLYTSKGDGWKGLGTGVVAEVNRVGNLLRELEKCFVASRADPKHKPTDYSAHYDGSNNSKLSASAIEKGTADGANLAHSDSLTILPNDKGNLSQTETAAQKEDIIMID |
Length | 1112 |
Position | Tail |
Organism | Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.283 |
Instability index | 48.01 |
Isoelectric point | 9.01 |
Molecular weight | 123369.27 |
Publications | PubMed=28196534
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11245
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 789.15| 276| 405| 362| 689| 1
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362- 689 (397.31/312.19) LFKQATELARSSWSDGLRVELL..HRTLVVQYWTLKPGAKSW.....LEIGiKSG...................................HRKSDSESPGLPSLKFRWlrdGdevPCEDIAfDAEN..LSMEtvlRSVIALHVSQILSsayskiRQSSLFStgvLSLC.......AHLTRTEPGDCQLDVQLTETrRLRVSIE......P.MSGMSILSATPTISDRFDME...RNAERPSVEDIVSRvARLRCNAAIEEieskvkmlgfeplNPRAW...........KADIRrifPSNVLRFTLFSHQlwGRDW......IVAATSSmdgdswwVG....QLRPTVTAkSHPVPQASGRDQSVLRSAQvvADSFFPAH.FDIDDAYLANLGHSLSgiLAIHSNAR.YLSD
739- 1098 (391.84/207.91) LIRDTIRLAFHGVDPREKCAIMvaYGNLVDSTASLAPLISSWdrslvFQKG.GSGfamrllapagrpvivsllenlqklecvlsvleslqRKRVEIRTFSLSSISFVY...G...PERDLA.ASLNihLSRS...ESLMELSPTELAS......RPESLFG...LRLGiqfglqnPHRRIQESLASSLNRSSTET.GLETVIEllmltlPlMRALDQLMSNPSYSGPLRLHvtvRNARTYQIHYPGDK.ARFQLVAASHQ.............NRLVWvlkdansqgetRNDDE...ATARLRQTLYTSK..GDGWkglgtgVVAEVNR.......VGnllrELEKCFVA.SRADPKHKPTDYSAHYDGS..NNSKLSASaIEKGTADGANLAHSDS..LTILPNDKgNLSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.11| 17| 17| 16| 32| 2
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16- 32 (33.01/22.02) HGPGNTYLQDGSSHSRG
36- 52 (32.10/21.20) QFNGDANAQDGPVHVNG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.98| 21| 378| 315| 347| 5
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315- 340 (30.94/20.64) FSPSPPVLK.GrllneIEMTINDVLQK
695- 716 (36.04/13.89) FHPPPHKLKiG.....PDLRVPDILVR
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