Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MTSLNQDQIKTLEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHLSDNRDLLSNIVAYPDASYPSRIPANNVALEQVLRTKLDPRVEDWVARGRRAGAPTTTSDTGAGALGQYHTNNGQGLLSDEAIAELWDWAPVAANEEARKRNWGGNYTLEEREMGIENVVTGLSRVLEDDDEEDESDSEEGEGEADEMEVVGVRRRSGAGAGLEFDIAAANTGSGAAAGAKMVAPVVPLDEILRFMTTGAAPGQR |
Length | 267 |
Position | Head |
Organism | Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.469 |
Instability index | 45.31 |
Isoelectric point | 4.45 |
Molecular weight | 28784.32 |
Publications | PubMed=28196534 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11243 No repeats found |
MoRF Sequence | Start | Stop |
1) AAAGAKMVAPVVPLDEILRFMTTGAAPGQ 2) GLEFDIAAAN 3) MEVVGVRRR 4) SNIVAY | 238 224 210 71 | 266 233 218 76 |
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