<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11239

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGGSITNIRVIDGFSNIYWRIYTEDTSSTNPASDGPNNGHTVLKHISRLKELELRLRSQGSLVLSYPRRLGLLIFSATPDFEHLSPTLLSERGDESNRLLVGSTILKVWTSGSVSSGELAKSHRSDFQTANANSPAPSQRLQGSSVQPRRVDNSGGSAAIYASFISAVTAAFSLQIVRQNNAIPLGPRTLFNTVESDLSGQGAVNDGPTSVPALTTLQVQLTSLGKLTIAFQTVVQTGLTRLNNPGENSLEAAPGTDLWLAPTGSIARLVAAHPEVNNNKLSFSASEGAGQWKQNVLEWLGYFGLPIDTVAGEGWVEVEVWEPFYSKLSGEAARVNQDGSTLPLKRILWPAAYCFRRTKSTQLEGPDKTEESPPFFCDPLDFAEDWYTKEIPKAAETDLELPSEGQERQVSNQDTLSPGFAGLPEGIESLSRASLYPEMQSASLVYPTPPDGTAGIGVNPAVSSDVFAEDLDHGPHLLQNQTKLKQNIRSTSKSGVDPDVTMEFGPAAGLGVGSGLYDTNDDDDLFGDMNERDFGTKGITDADFSFFDDGFDQSGKGSNIGRSQESPDFVDPGKPNAVVELSERIAPSPNSVPIEAKDVTEESPEKTHDPPRHEPIPENNAPMSSSHYGQMQTISPPLSPVEVKRILFPDPSSNKQLVAKGTHVPSHYSPVAFKSNVSSWDKKYGADGKFSFVGTGTTFTQDPYTSTDGIPTIGLPRRKSNVKTLAHSKAPNGDELSPNEIESSSSPDSSSETDESDNGGLENNIPPAALATLKRKRARSSPGNSPISSSDKGLAGLQGISIHKSEDPVFLGNFLSTFSDWSIAGFFSLSESQVFPSLAPQEVQVQVAQLLVDQITQSSLDHKLDGKFGVSCLDNQAFSLRELLGASEYLGSFDKLDLNAFVSLQEQNPFSPDALSGLTPRQNSQRKEPGKGSITRLPVPHLRVRRGKAFLETLPPAISFWETFDLEPTHGPKDITAYCIHPHIMTRTADAFLERLGLLYTSCNLGSHSRGNCSDGFNNGLAEWAVNPSKQTNYSSMMQKLKDICGDLGSALLESPSSNDNIIIYIINPFSHAASLVDICAAFWCLLQNYFASEDKQQPKQLNEVQLQVIPMDFVTSAESLVVPPQPDYLSLALEVYSRCSTSQVQSSLVNCTPPVMLAETLPQSIGFKLASESAPPMQEGKCLHVACSKSQDQRWMSVAWSDNSGVLQRTMSYCIRFRNSTTSRALPSVRSEIWAATKDIMDKSQARWRVILVNTENVDQDEHDTWLNLAEQYNKSRPVPVELTILSVNTAADLTLSPPRSPMPMSVLNPQTSPTPIATPLPSGSILSPDQVGNAPTPPSGTNAPANAPTPTDALFESESESLLTDICDESWSVVLSHRLNGTLHLTEYRPALASGYLLRRKGPTDADGAFSMNVNLLFTQRSSSSHEHTLREIIGMYRDLATLARVRGTRIVQTGTLPWHIATAVRAQEILSYIL
Length1480
PositionKinase
OrganismAspergillus sydowii CBS 593.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.368
Instability index52.31
Isoelectric point5.08
Molecular weight160656.55
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP11239
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.15|      32|      40|     915|     954|       1
---------------------------------------------------------------------------
  248-  276 (23.74/ 6.46)	PGENSLEAAPGtdlwlapTGSIARLVA.AH..........
  923-  954 (60.18/36.86)	PRQNSQRKEPG.......KGSITRLPV.PHLRVRRGKAFL
  971-  996 (42.23/16.58)	PTH.......G.......PKDITAYCIhPHIMTRTADAFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.94|      38|      40|     739|     776|       2
---------------------------------------------------------------------------
  394-  442 (22.78/ 6.63)	...IPKAAETDLelpsegqerqvsnqdtL.SP.........GFaglPEGIESLSrASLYP..EM
  635-  656 (25.76/ 8.59)	QTISPP.......................lSPVEV...KRILF...PDPSS.............
  739-  764 (34.26/14.16)	............................L.SPNEI...ESSSS...PDSSSETD.ESDNG..GL
  765-  800 (43.14/19.98)	ENNIPPAALATL.......................krkRARSS...P.GNSPIS.SSDKGlaGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.66|      34|      42|     157|     198|       3
---------------------------------------------------------------------------
  157-  196 (47.14/45.00)	SGGSAAIYASfiSAVTAAFSLQIvrqnNAIPLGPRTL.FNT
  202-  236 (53.52/28.11)	SGQGAVNDGP..TSVPALTTLQV....QLTSLGKLTIaFQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.21|      18|      40|     823|     841|       4
---------------------------------------------------------------------------
  823-  841 (28.89/27.48)	DWSIAGFFSLS..ESQVFpSL
  864-  883 (28.32/19.65)	DHKLDGKFGVSclDNQAF.SL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.65|      27|      33|    1289|    1320|       6
---------------------------------------------------------------------------
 1289- 1320 (46.41/35.74)	ILSVNtaadlTLSPPR...SPMPMSVLN.PQTSPTP
 1325- 1355 (43.24/22.86)	LPSGS.....ILSPDQvgnAPTPPSGTNaPANAPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.14|      42|      49|    1127|    1172|       7
---------------------------------------------------------------------------
 1127- 1172 (71.07/58.57)	PPQPDYLSLalevYSRCSTSQVQS..SLVNCTPPVMLAETLPQSIGFK
 1179- 1222 (74.08/51.48)	PPMQEGKCL....HVACSKSQDQRwmSVAWSDNSGVLQRTMSYCIRFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.24|      24|      40|    1006|    1031|       8
---------------------------------------------------------------------------
 1006- 1031 (42.43/29.05)	C.NLGSHSRGNCSDgfNNGLAEWAVNP
 1048- 1072 (35.81/17.42)	CgDLGSALLESPSS..NDNIIIYIINP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.36|      30|      44|      74|     108|       9
---------------------------------------------------------------------------
   74-  108 (40.89/38.10)	GLLIFSATPDFEhlspTLLSERGDESNRLLvGSTI
  120-  149 (52.48/31.83)	GELAKSHRSDFQ....TANANSPAPSQRLQ.GSSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.62|      16|      20|     569|     587|      16
---------------------------------------------------------------------------
  569-  585 (24.82/23.11)	SPDFVdPGKPNAVVELS
  591-  606 (27.81/12.48)	SPNSV.PIEAKDVTEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.45|      26|     719|     702|     730|      17
---------------------------------------------------------------------------
  702-  730 (42.91/36.50)	FTQDPYTSTDGI..PTIGLPRrksNVKTLAH
 1423- 1450 (41.55/26.70)	FTQRSSSSHEHTlrEIIGMYR...DLATLAR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11239 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKSHRSDFQTANANSPAPSQRLQGSSVQPR
2) EMQSASLVYPTPPDGTAGIGVNPAVSSDVFAEDLDHGPHLLQNQTKLKQNIRSTSKSGVDPDVTMEFG
3) KAAETDLELPSEGQERQVSNQDTLSPGFAGL
4) LSPVEVKRILFPDPSSNKQLVAKGTHVPSHYSPVA
5) LTLSPPRSPMPMSVLNPQTSPTPIATPLPSGSILSPDQVGNAPTPPSGTNAPANAPTPTDALFESES
6) SFFDDGFDQSGKGSNIGRSQESPDFVDPGKPNAVVELSERIAPSPNSVPIEAKDVTEESPEKTHDPPRHEPIPENNAPMSSSHYGQMQTISP
7) SFVGTGTTFTQDPYTSTDGIPTIGLPRRKSNVKTLAHSKAPNGDELSPNEIESSSSPDSSSETDESDNGGLENNIPPAALATLKRKRARSSPGNSPISSSDK
123
441
396
641
1298
548
694
152
508
426
675
1364
639
795










Molecular Recognition Features






MoRF SequenceStartStop




1) LATLKRKRA
2) VKRILFP
773
646
781
652