<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11236

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDGINVDDLFGESTSLELGLPPNTSPAPVKGLAQRLDEMRLVGCCQKIAWSRLGCVAYISQDSSRVNVRHLQCQKSNGKWTLSDETPLNQVAEAHDGYALVHLCWNESGSELAIADTSGRVSIYSIPIALNSVNGARQAAFDVADDGAQIVGMMWLNQNRSVHSFYQAAKVQGRWAYSPFRRRPIAPFHPANKAALLCITRSGSMKLLYQNPDNKWAEITTELKSTSYSDRFLTHAALVATQAGILIATHSACQKISVYRVSIQWNPPQWDPAQQKQGTQQYPVPSFRSIHSKVEMPYNIPNTRGSAGENPDEQSTLTSSLYCLTSLQIILPASDNSAGSTPNPWVVAVFSIPPHAILHQQPQAPASAIIRWQLETGIPTLHPKFDEVASKKSNVQIKPKTILRRLDDITSARHVISVDQTEYGNVLAVSYDDSSISFYDPKTMTAFDIVDDANTVTSLAQAGFNYPLDSPATHIAFSPSACAAVGLDSDGQIHLRIMEHSYGAENGEYDENKFSAAIASLTLAFCRGCGGEVNTDDILLLLIRQLPQDSQTGFLNEVYRALSINCNFTTEHDKLMNHPYISRALSIQAALGFKNKYKTRNIASNVPWAIIQLRQAAIIYPFFFQYNKGSQPPEPHDPDVLRMVLGNTKWVLDFFLYTLNELFDLADEFESVPADQEAFNQKLKSTASLPLIVVLSSMSRAFLRFICRGLRGIHSGYANAPLTGDARVYYTEICHALETSPVRTDVYEKLLAGVDSAVRHAYTGAGFGDNERPGPEKELLVSSRIPPVLVTAVSTILRQTIPSMKAEVDRMAIFMGDYSWLGFGSDARTEAYRRSREVDIIKKTPIFRAVAGAGTGRLGTLEMGDLGAKSGTQGHLSRRCVRCCEASEAVYPPRSVPAFRMIYKLGHLRSCICGGMWDLESGLMN
Length930
PositionTail
OrganismAspergillus sydowii CBS 593.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.08
Grand average of hydropathy-0.187
Instability index41.36
Isoelectric point6.55
Molecular weight102506.30
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11236
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.91|      14|     178|     523|     536|       1
---------------------------------------------------------------------------
  523-  536 (28.06/16.97)	IASLTLAF....CRGCGG
  700-  717 (21.85/11.69)	LSSMSRAFlrfiCRGLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.81|      48|      94|      63|     115|       2
---------------------------------------------------------------------------
   63-  115 (75.77/62.19)	YISQDSSrVNvRHLQCQKSNGKWTLSdetPLNQ..VAEAHDGYALVHLCWNESGS
  160-  209 (85.04/52.74)	WLNQNRS.VH.SFYQAAKVQGRWAYS...PFRRrpIAPFHPANKAALLCITRSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.01|      25|     213|     452|     477|       3
---------------------------------------------------------------------------
  452-  477 (40.65/31.06)	FDIVDDANTVTSlAQAGFNYPLDSPA
  668-  692 (43.36/28.40)	FDLADEFESVPA.DQEAFNQKLKSTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.65|      21|     177|     551|     581|       4
---------------------------------------------------------------------------
  551-  572 (33.22/35.61)	LPQDSQTGFlNEVYRALSINCN
  590-  610 (34.43/13.58)	LSIQAALGF.KNKYKTRNIASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.90|      27|     866|      26|      55|       8
---------------------------------------------------------------------------
   26-   55 (44.89/34.67)	PPNTSPAPVK.GLAQRLDEMRlvGC.CQKIaW
  272-  287 (26.55/12.01)	PPQWDPAQQKqGTQQ................Y
  897-  922 (46.45/26.20)	PPRSVPA.FR..MIYKLGHLR..SCiCGGM.W
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11236 with Med16 domain of Kingdom Fungi
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