<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11234

Description Uncharacterized protein
SequenceMIPHSSAGVQSWGHPLRKLDNGSGRVDASQAPSLSDFRSETQQSTPVLPPHTGQPAVIDLTSSVNDVQEREPPAKRLRLDVSAGSSAKDASPAPATGGEPRATPGIANAKPSSLSWRGRPVWSFQAMVSEATNAREVIEDDAGLTPEGKRPASPPPFPPLPWKGAPPEQFGNNATKTSEPATSKEVQTTPFRVQIPSIAPVLKGDRIADFAPWTGNHPEDALNDQTVKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVLMAALEKRQNHNTVNAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKALLDQCLSKLIPVSRAVWLAKCVGANEIRAFKRKGTSGSLAIGLEAKWVREWTSGVQQFLEGVVGACGSTGWKSKMTYAASLTARLFFERLLDHDQYFTWFLASLEASPLNMIPVWLLMLGIYWDSLLRYRKRGRRLAEVLLGKLRQITELRQPILLQPLADRLSSYIRKLVLEHTSSVILPNLWETHRNLILSCLKMKEAADKTIYDTLAERNARVQLPKSRPESTQQSAQQHVVQLFDSVRSSHDISSTSAACLSALEDRISLVAKLLEWSATRFRSGLRRVYTAARLLRKWKMSGIDIDTYIILFVSTVKDTAQLDMGNVYHVISELVRSQTFSISRYLQWLMAKGVARHASGDDDEGLAGDTLLLTQLPMGRLPEHVRNLRFTLLARTGMSATEESSTIQDMKFAISQRLPNVFHVKDSNAIFTQLPQLNLTWAVKSEVSIWIRQGVVKHLRNTTRKIAGRPLSGDSKVSALTSEEFYCIREILEDFGDLSILADVLKQATECDDNTVLASASDTINYHFDALSIIGATSDLFRGLIGAYARLKRFGTLNLDFTFSLIELGLRIPEESSTVSLLRQDLARIESKAALAAPSPLSDHIPTTFSDSDASFQDKLDQLLSCGNGIDESTMGSVFNSLTKILTFGSGTTKLSAKDACRYLAYLRPFSPKYFDIMLVRYVCGLLKSSSRPTMSHILPHLIGVGCVTIHSFVLLVNKLSAPEKTVPAIPNLSRLRLDILELLIPRSEPNADLVTYRFRLAQQEFLVKYSDESLSIINDAIPLLDSLEDVNLGARRPDLQACTAKLLRSLLTQSSSSVAEYCMRELTGHSSFTTVVGKAVDLLLGFDPQDETDPSAQAEKVILMNNDFSLPFCQLKLQLLFHANPGDEVKSNIVHVMFKAAVADSRSRKSHWVGLVNLMNQDAARQIRERAESSFFSVPMFDDPADDLSLSDGAASTDAIENAKLYITIIEKLAYSIPESGVPSVAPLLVERLDLLLQKLIIMQTNTSSFAENRSVSSSGPVVMARFNFERSLAFWFSALLRMTVLHRAAFNAPASLGPKAGSLQEQTRLLVSIFCISLARLPDNILRLFPTANYFPHTIQPKNFRPCPGILLQTHALDVAASLIDSFPDEARLQCGRFLKEKCPPFLQFQNDRRFLYLLGPMTDTAIHSSQLPASISSPAAGGSTPTPTPSGSVSAGPPNQSQQVAASTGVLPGLSEITNPVADRLRIQHRGRVIGPYPVRPWELLEDAAPILGVNDTAVSLKLFDARRVRA
Length1596
PositionKinase
OrganismAspergillus sydowii CBS 593.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.157
Instability index50.19
Isoelectric point9.01
Molecular weight175987.43
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11234
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.97|      21|     150|      12|      48|       1
---------------------------------------------------------------------------
   12-   32 (40.73/13.01)	WGHPLRKL....DNGSGRVDASQAP
   70-   94 (32.24/25.38)	REPPAKRLrldvSAGSSAKDASPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.04|      22|     149|     420|     472|       2
---------------------------------------------------------------------------
  450-  472 (34.93/63.19)	WdSLLRYRKRGRRL..AEVLLGKLR
  598-  621 (36.11/ 6.45)	W.SATRFRSGLRRVytAARLLRKWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.98|      41|     149|     653|     693|       3
---------------------------------------------------------------------------
  653-  693 (66.86/46.79)	ISELVRSQTFSISRYLQ.....WLMAKGVARHASGDDDEGL...AGDTL
  762-  793 (41.86/26.27)	........TWAVKSEVS.....IWIRQGVVKHLR.NTTRKI...AGRPL
  799-  846 (49.26/32.34)	VSALTSEEFYCIREILEdfgdlSILA.DVLKQATECDDNTVlasASDTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     489.94|     113|     255|    1035|    1147|       4
---------------------------------------------------------------------------
  900- 1022 (108.27/73.66)	TVsLLRQDL..ARIEsKAAL..............AAPSpLS....D......HIPTTFSDSD.ASFQ.DKLDQLL.........SCGNG..I.DESTmgSVFNSL......TKILTfgsgttklS.AK......DAcrYL..AYLRPfSPKYFDIMLVRyvcGLLKSSSRPTMSHILP
 1035- 1147 (175.05/125.10)	FV.LLVNKL..SAPE.KTVP..............AIPN.LSRLRLDIL..ELLIPRSEPNADLVTYR.FRLAQQE.........FLVKY..S.DESL..SIINDA......IPLLD........S.LE......DV..NL..GARRP.DLQACTAKLLR...SLLTQSSSSVAEYCMR
 1162- 1288 (82.50/53.81)	AV.DLLLGF..DPQD.ETDPsaqaekvilmnndfSLP..FCQLKLQLL..FHANPGDEVKSNIVHVM.FKAAVADsrsrkshwvGLVNLmnQ.DAAR..QIRERAessffsVPMFD........DpAD......DL..SLsdGAAST.D.AIENAKL.....................
 1290- 1411 (124.13/85.87)	.I.TIIEKLaySIPE.SGVP..............SVAP.LLVERLDLLlqKLIIMQTNTSS.FAENRsVSSSGPV.........VMARF..NfERSL..AFWFSA......LLRMT........V.LHraafnaPA..SL..GPKAG.SLQEQT.RLLV...SIFCISLARLPDNILR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.83|      22|     169|     701|     727|       8
---------------------------------------------------------------------------
  701-  727 (33.29/33.93)	GRLpehvrNLRFTL.LARTGMSATEESS
  877-  899 (35.54/22.11)	GTL.....NLDFTFsLIELGLRIPEESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.31|      19|     328|     103|     122|      10
---------------------------------------------------------------------------
  103-  122 (33.36/22.67)	TPGiANAKPSSLSWRGRPVW
  169-  187 (29.95/15.40)	QFG.NNATKTSEPATSKEVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11234 with Med12 domain of Kingdom Fungi
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