<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11228

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDQNTACGRDPDLRDNVNSNQSTQMNPSHSGNAVELKNGLLHTNGFRHVDQYPDTETAESAETTTASPTAKKSPELQHITQGFLPLSKLVNRSVQQCWNDLADLVAELAGIEVPSQASNTSSMVVNGKVPGNQSAENVRKKLRALEFTQARREEFIKLLVLSQWSRQAADVSKLIDIQNYIRTQHQAYAAALQWMGDMKRDLVRAQVANPDLRTALEVLSKGEVASMPDLGYKPPKTLTPKSALGKLRKINRVISARLALHENVPLPFQNYRIHNGRVTFLVPEEFELDLSIGEEDATSQLFFVDIRFIFKPSPSVPAGRLFSELDLKLNDILQNCGLPGCYDWLHSLVLTNKINVLAKQAFSLTRGLWANVLRIELLHRTLVLQYWSSKPGAKSWLEIGIRRGLSANNGEGQHSPALGLRWIMDGREVNSEGIDFDTQNLSVEYLLQSVIALHISHILSSAFRIIGEKLLYSNGSLSLQGHLTKSEPGHCQLDVQLTASRRLRVGIEPMSGMIILAATPNTLERFDTDRNTERPIIDDIVSRVTQLRCAAAIEEIESQVKMFGFESVSHRNVKIDARKVFPANVIRFSFFWHRLWDHTCLLAATSGMDGDNWWVVQTRSADLTTANRSFGARAHANCFVCSTQVICNTLLPVQKAGHSPLADLGHCLSGFLAIYANGRFLEDLQFAKILPPLKRLKIGCALQVPDLSIEYEPTKLPQALRIALPAGFKKKAFLKNTLRLTFHGIDRHRNVAIMVAYGKLSAQFQNLRDLIPKDDHSLTFQKTGSGFALRLIASPGYPVILTLLANLQKLECALSIYDLLQLKNMDTRSLSLSCISFAYGPDRDLLAQFDIGGSNPHLSTETDPAKLASRTDPLFYLRLAIKFDYSNPHRRIQGALTSNLNRPTTDAGLDTFAELLSFTLPLMRALNRLLVNAAHNERLKVHVTVRGTKAFQINYPLERCQFKITAHQHQNQPVWVLKDLSNTQNGCDENTSKYKLQKSLYNRNGLGWRGLGNGAVAKPDAVGNLLDELDKCLAAIRAEVTSKPLDSKPNPDNMVNNELQDTGLAKPTEAFTDPCEGTGNRNKQQKKVAGQKADIIMID
Length1104
PositionTail
OrganismAspergillus sydowii CBS 593.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.255
Instability index36.97
Isoelectric point8.95
Molecular weight122830.19
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11228
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     219.77|      72|     173|     479|     580|       1
---------------------------------------------------------------------------
  479-  573 (103.35/106.54)	NGSLSLQ..GHLTKSEPGHCqldvqltasrrlrvgiepMSGMIILAATPntleRFDTDRNTERPIIDDIVSRVTQLR..CAAAIEEIeSQVKMFGFESV
  653-  712 (82.21/46.33)	NTLLPVQkaGHSPLADLGHC..................LSGFLAIYANG....RFLEDLQFAK.....ILPPLKRLKigCALQVPDL............
  803-  835 (34.20/ 8.27)	...............................................................PVILTLLANLQKLE..CALSIYDL.LQLKNMDTRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.23|      38|     832|     205|     254|       2
---------------------------------------------------------------------------
  205-  243 (63.24/49.19)	RDLVRAQVANPD.LRTALEVLSK......GEVASMPdLGYKP.PKTL
 1014- 1059 (51.99/21.94)	RGLGNGAVAKPDaVGNLLDELDKclaairAEVTSKP.LDSKPnPDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.95|      57|     264|     309|     376|       3
---------------------------------------------------------------------------
  309-  376 (83.82/74.83)	VDIRFIFkpspsvPAGRL.FSELDLKLND....ILQNCGLPGCYDWlhsLVLTNKINV.LAKQAFSlTRGlWAN
  580-  642 (92.13/53.53)	IDARKVF......PANVIrFSFFWHRLWDhtclLAATSGMDGDNWW...VVQTRSADLtTANRSFG.ARA.HAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.44|      30|      40|      16|      46|       4
---------------------------------------------------------------------------
   16-   46 (47.59/31.86)	PDlRDNVNSNQSTQMNPS..HSGNAVELKNGLL
   58-   89 (45.85/26.30)	PD.TETAESAETTTASPTakKSPELQHITQGFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.20|      41|      45|     840|     880|       6
---------------------------------------------------------------------------
  840-  880 (72.97/46.67)	ISFAY.GPDRDLLAQFDIGGSNPHLSTETDP.AKLASRTDPLF
  886-  928 (63.23/39.41)	IKFDYsNPHRRIQGALTSNLNRPTTDAGLDTfAELLSFTLPLM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11228 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HTNGFRHVDQYPDTETAESAETTTASPTAKKSPELQH
2) MPGVVMDQNTACGRDPDLRDNVNSNQSTQMNPSHSGNAVELKNGL
3) VTSKPLDSKPNPDNMVNNELQDTGLAKPTEAFTDPCEGTGNRNKQQKKVAG
47
1
1045
83
45
1095










Molecular Recognition Features






MoRF SequenceStartStop




1) QKKVAGQK
1090
1097