<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11226

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTPSAPLRTGPPSPSSPAPFTSFKDSLQPPITPDQIPQTPTSPPLMSVSAPNNASDFASMQALPNQATSQPASLSSPPSSAPMSTQTSQQPTTGITNSFPTPASSVDPDHSDKSFGTGISETGAPAPASASAAPTQKSEYRRTDHDRNLETPQTGTGVRDFAQMGGSSQVLHGDAMELDTEPSAHTKSNWPSLESLQKEFSSAFHLCKSSHIATGPDPSVDLISLYGLGPVARSVARNDPVTGEKINRLRKSYEGKLKGLGLSGRNKAVKHDPSSSGGLRQMMMWPEEEWQNQKVFGKEIKVADMDSALHNLQMKAMKMEPGPVPNNDYWEDVLGHDKPTKNTNTGEAAKKPAAPQSSVRTAAQPNGTPISAEPERSRPSRGRKRNYDDNSFVGYGEGYADDDDESGFYSNSEGGGKKKRKKDHVSKIPAPPDRGGSYGVGMFGIGAR
Length451
PositionHead
OrganismAspergillus sydowii CBS 593.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.865
Instability index50.75
Isoelectric point6.81
Molecular weight48059.49
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11226
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.97|      29|      31|       3|      31|       1
---------------------------------------------------------------------------
    3-   25 (36.90/11.87)	...........DRTPSAPLRTGPP..SPSSPAPFTS
   26-   59 (36.52/11.67)	FKDSLQppitpDQIPQTP..TSPPlmSVSAPNNASD
   60-   88 (38.79/12.81)	FA.SMQ..alpNQATSQPASLSSP...PSS.APMST
   89-  113 (34.76/10.79)	.QTSQQ........PTTGITNSFP..TPASSVDPDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.96|      19|      37|     282|     302|       2
---------------------------------------------------------------------------
  282-  302 (33.60/35.40)	LRQMMMWP.....EEEWQNqkVFGKE
  317-  340 (31.36/24.55)	MKAMKMEPgpvpnNDYWED..VLGHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.53|      16|      31|     228|     243|       3
---------------------------------------------------------------------------
  228-  243 (30.07/16.31)	LYGLGPVARSVA.RNDP
  260-  276 (25.47/12.83)	LKGLGLSGRNKAvKHDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11226 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRTPSAPLRTGPPSPSSPAPFTSFKDSLQPPITPDQIPQTPTSPPLMSVSAPNNASDFASMQALPNQATSQPASLSSPPSSAPMSTQTSQQPTTGITNSFPTPASSVDPDHSDKSFGTGISETGAPAPASASAAPTQKSEYRRTDHDRNLETPQTGTGVRDFAQMGGSSQVLHGDAMELDTEPSAHTKSNWPSLE
2) SALHNLQMKAMKMEPGPVPNNDYWEDVLGHDKPTKNTNTGEAAKKPAAPQSSVRTAAQPNGTPISAEPERSRPSRGRKRNYDDNSFVGYGEGYADDDDESGFYSNSEGGGKKKRKKDHVSKIPAPPDRGGSYGVGMFGI
1
310
197
448










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHVSKIPAPPD
2) SYGVGMFGIGAR
420
440
436
451