Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAEVQSALSTFESRLNSLVTTLTTSPTASGAPAAAVNLLAADDTLTSTIDTLKQHQANYARILQLRAEAQSLEERVKDIVRLVVRYEKDIREVCGDDGSDSDSDDSDSDEDMDGEDKPEPVSHKRNEIDYKLLLDFARRISKYNNEAAADAAAGMTKKGHAITSQDTEMGGITANGAQDGSSDAEPVAAVTKDATSWLDESANMTRQVYMLPYPMEDRIRMGLMGQIQLAAAEGRPGFDTDNEVERLIREAEGEGVADAVAPAPVGEETKRVNEAAMAAAHAGSAAATGVSVAPAPKPKAALDLDLYDPDEDED |
Length | 315 |
Position | Middle |
Organism | Aspergillus sydowii CBS 593.65 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.520 |
Instability index | 40.77 |
Isoelectric point | 4.35 |
Molecular weight | 33603.52 |
Publications | PubMed=28196534 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11225 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 40.68| 12| 31| 252| 265| 1 --------------------------------------------------------------------------- 252- 265 (18.25/16.15) AEGEGVadAVAPAP 286- 297 (22.43/12.54) AAATGV..SVAPAP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KAALDLDLYDPDEDED 2) SAAAT | 300 285 | 315 289 |
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