<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11218

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDSITVDDLFGVSTTLELGLTSPSPSSVTKGLAQRIDELRLLGCCQKVAWSKLGCIACISQDGLRVNVRHLQCRPSDGKWVLSADTPLLPVTEAHGGNPLVHLSWNETGSELAIADSSGRVSIYSVSIALNSIQGLRQAIFDQEDDAAQIVGMMWLNSQRSVHAFHQAAKMNGRWAYSPFRRRPTPPFHPGNKPALLTLSRSGQLKLLYQNPDSRWAELSAELKNTGHSDRLLTHATMVATQNGILVATYSSCQKICLYRVQINWTQLDNSQPKPAPPSAQFQTPAFRLHHVKIESPGNFLGPNRNLGESSEDFPSFPSSVYCLTHLTIIQNPLDNPTGTATGPYMIAVYANPLCASPDHAGVHGSASVIVRWQLDTASQTLHPKFDEVASKKTSIQAKPKVELRRLEDVYSDKHVISVEVTEYGNVLAFTHDDGSVSFYDPKNMTTFNGVDDTNTVTSLAQVGFLYPIGIPGFHVAFSPNACIYAVLDGDWQMHLRVMEHSFGAEQGLYDDTKFSAAVASLTLAFCRGCGSDVNTDDILFLTLQQLSSEAQNTLISEIYRALPINCNFTAEQEKLLHHPYIPRSLSLQAALGFKTSSKPRDLVAAVPWAILNLRHASLLFVYFFQYNKGPQTEPHDAYVLRMVLGNTKWALDFSHYIMNEVFDLVDEFESVFNDQEAFTQKLKSTSSLALIILLSSMSRAFLRYICRGLRGVYAGFSNAVALSGDARVYYTEICQTLDASPVQIDVYEKFLAGVDSAVRHAYQGAGFGDAERPNPEKELLVNARIPPVLIPAVATLLKQTVPALKPEIDRMAIYLCDYSWLGFTDDRRTELYRKTRSVDVLKKIPLSVVPNPSCEGENGKMTTATPLPSPPRRRRCVRCCEISGDISTPRSLLSFRMVAKMGILRSCLCGGMWTFASGSGDPVDNS
Length932
PositionTail
OrganismPenicilliopsis zonata CBS 506.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicilliopsis.
Aromaticity0.09
Grand average of hydropathy-0.130
Instability index42.74
Isoelectric point6.50
Molecular weight102836.08
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11218
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.24|      56|      61|     787|     847|       1
---------------------------------------------------------------------------
  790-  847 (89.90/70.98)	RIPPVLIPAVAT.....LLKQTVPALKPEIDRMAIYLCDYSwlGFTDDRRTEL.YRKTRSVDVL
  849-  910 (90.33/56.07)	KIPLSVVPNPSCegengKMTTATPLPSPPRRRRCVRCCEIS..GDISTPRSLLsFRMVAKMGIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.60|      68|     179|     526|     605|       2
---------------------------------------------------------------------------
  526-  605 (101.36/82.22)	SLTLAF....CRGCgSDVNTDdilFLTLQQLSSEAQ..NTLISEIYRALPINCN....FTAEQEKLLHHPYiprslslQAAlGFKTSSKP
  702-  779 (106.24/59.10)	SMSRAFlryiCRGL.RGVYAG...FSNAVALSGDARvyYTEICQTLDASPVQIDvyekFLAGVDSAVRHAY.......QGA.GFGDAERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.41|      35|      38|     274|     308|       3
---------------------------------------------------------------------------
  274-  308 (64.52/32.03)	DNSQPKPAPPSAQFQTPAFRLHHVKIESP.GNFLGP
  314-  349 (58.89/28.68)	ESSEDFPSFPSSVYCLTHLTIIQNPLDNPtGTATGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.24|      44|      93|      71|     114|       4
---------------------------------------------------------------------------
   71-  114 (82.58/52.61)	VNVRHLQCRPSDGKWV.LSADTPL..LPVTEAHGGNPLVHLSWNETG
  167-  208 (68.24/42.11)	VHAFH.QAAKMNGRW....AYSPFrrRPTPPFHPGNKPALLTLSRSG
  210-  240 (34.42/17.35)	..LKLLYQNP.DSRWAeLSAE.....LKNT.GHSDRLLTH.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.33|      50|     426|       6|      61|       5
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    6-   61 (67.81/70.75)	DDSITVDDLFGVsTTLElGLtsPSPSSVTkGLAQrIDELRLLGCCQ.KVAWSKLGCI
  439-  489 (88.52/61.56)	DGSVSFYDPKNM.TTFN.GV..DDTNTVT.SLAQ.VGFLYPIGIPGfHVAFSPNACI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11218 with Med16 domain of Kingdom Fungi
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