Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSNSVASTSYRVGPPSPPSPPAGSLKEQHSHPPPFPLLAIEEIPQTPTSPPLMSVSAENYASNITSSQTSPSQTTAQPTNFSSPPSSAPMSTQTSQQPTMMTVTNSFPTPASSVSGHGMGATAADDLDHSENSFPSSDPQSLRSAAPTIHEHRRTDHDRHWTDAQQAAVGVRDFANSGGREDLPKDGDAMDVDKDTTNPNDSDLASLQKDFTSAFHLCKSSYTATGPNPSLDLISLYGLGPVANSVARIDAVTGEKINRLRKSYEGKLKGLGLAGRNKPVKLESGASGGLRQLMMWPEEEWQNQQVYGKQIKVADMDTALYNLQMKAMKMEPGPVPNSDYWEDILGHEKPSKQTGTPAVATVTSAADGKKPTGSIGTPRPNIAANGTPHPAELERSRPSRGRKRHYDDNSFAGYGEGYADDDDDGAFYSNGEGIGKKKRKKDHVSKVSTPIPERGGSYGVGMFGIGAR |
Length | 468 |
Position | Head |
Organism | Penicilliopsis zonata CBS 506.65 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicilliopsis. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.779 |
Instability index | 47.30 |
Isoelectric point | 6.13 |
Molecular weight | 49932.52 |
Publications | PubMed=28196534 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11216 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.18| 23| 27| 183| 207| 1 --------------------------------------------------------------------------- 185- 207 (42.49/26.75) KD.GDAMDVDKDT...TNPNDS.DLASL 209- 236 (29.69/10.94) KDfTSAFHLCKSSytaTGPNPSlDLISL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 149.93| 52| 62| 15| 72| 2 --------------------------------------------------------------------------- 8- 70 (73.87/48.23) TSyrvgpPSP.PSPPAGS.LKEQHSHPPPFpLLAIEEIPqTPTSpplmSVSAENY....ASNITSSQTS 71- 133 (76.05/34.22) PSqttaqPTNfSSPPSSApMSTQTSQQPTM.MTVTNSFP.TPAS....SVSGHGMgataADDLDHSENS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.17| 17| 91| 240| 256| 5 --------------------------------------------------------------------------- 240- 256 (29.54/15.65) GPVANSVARIDAVTGEK 333- 349 (34.62/19.37) GPVPNSDYWEDILGHEK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FPLLAIEEI 2) IGKKKRKKDHVSK 3) YWEDIL | 35 434 340 | 43 446 345 |
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