<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11214

Description Uncharacterized protein
SequenceMTSVAAPAGTFLPGTKVHVGSHRVVVEKYLSEGGFAHVYVVRLPQPVDDVDTAVLKRVAVPDKMALANMRTEVETMKKLKGHRHIVTYIDSHASQLRGGGYEVFLLMEYCDGGGLIDFMNTRLQNRLTEPEILHIFDDVAEGVACMHYLKPPLLHRDLKVENVLISRASASVCYKLCDFGSAAPPRPAATTAAEGRLIEDDVQRHTTLQYRSPEMIDVYRKQPIDEKSDIWALGVLLYKLCYYTTPFEEVGQMAILNASFKFPPYPQFSDQLKLLIATMLKETPQKRPNIYEVLSQVCRMRGKEVPIRDIYAGRTTSEARRYQELPPSPVEAPRVGAVFSPPMQETRIIPEIAPMRRGRPSKPSSQQSSAKPSPSPYRGSTDPFAALDGHSTKGAATATTTTSVKTDEISARFPTLDQFSILHEKGDKFDFEPTLADSKATTEDEDLARRLTNALADDAFVKLSSPDSKPSVRDQPSVRESSSHRRPQTSPMETRDSPQQKWQQQQQTPLYQPVPQKPSMVSTGTMTSPPSTPKQPQPSLLSSRPIYRFPPSESTSSTAADHRASSQPQPSPRTSAEKIAGLSGSARPSLETSRPSTLDLLGTVDHDPVTRSKSANAAKVRPVSVHAGGMRERSREPDTTRSSIDVVRTTTAAAANYEGGAPLRHARTEIETERSQIVSDVDYLRAKEEEESNRKREKRYSSNGGVGGGAKHIKRTSLSNLSLAGTKTLFAGRFGEAFRRFESSGSGSDSNKARTPSPDETAVPARQPTPDMREGGVGSSGGNDLPMVEDETAEPEDDISPEMRRELERRRLSQEEKRVAQAAADYRRRVAAGGGGGGGGGGGAGMRSASIQNKVQSLLQDHSNKPPPPKTATGYGRYTEEAAVTSPSEANVVVAVSTGQRTGSRPAAPPKPKKLQAVNVNSVSTGNVNSVSTGNAGTPASVAPDSPDWETSFSRRFPSLSGLEMVEREIEIPIMIPLTKEQADFPDDLKEVIQHLFEIQSAVHGYLGPETQQELVRKIKNLTTSLATLTSHTNPSASDPNNNPHDPSPSLASIQLPPEIIDYVDASRNPDIYTREFVELVQRGNQDLKGKQAAFASFRDVLAREMRGAMPECTHEVNRAVEATGGVID
Length1129
PositionMiddle
OrganismPenicilliopsis zonata CBS 506.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicilliopsis.
Aromaticity0.05
Grand average of hydropathy-0.625
Instability index59.34
Isoelectric point7.37
Molecular weight123149.60
Publications
PubMed=28196534

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11214
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     174.95|      30|      30|     510|     539|       1
---------------------------------------------------------------------------
  471-  499 (37.10/13.35)	SV..RDQ..PS.V.RESSSHRRPQTSpMETRDSPQ
  500-  530 (46.88/18.71)	QKWQQQQqtP..L.YQPVPQKPSMVS.TGTMTSPP
  531-  562 (39.38/14.60)	STPKQPQ..PSlLsSRPIYRFPPSES.TSSTAADH
  563-  585 (27.01/ 7.81)	RASSQPQ..PS.......PRTSAEKI.AGLSGS..
  586-  608 (24.58/ 6.47)	.....AR..PS.L.ETS...RPSTLDlLGTVDHDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.83|      14|      18|     301|     314|       3
---------------------------------------------------------------------------
  301-  314 (24.97/15.05)	RGKEVPIRDIYAGR
  321-  334 (24.87/14.96)	RYQELPPSPVEAPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.82|      29|      30|     745|     773|       4
---------------------------------------------------------------------------
  745-  773 (53.77/30.48)	GSGSDSNKARTPSPDETAVPARQPTPDMR
  776-  804 (53.05/29.96)	GVGSSGGNDLPMVEDETAEPEDDISPEMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.26|      26|      34|     884|     912|       5
---------------------------------------------------------------------------
  884-  912 (37.04/28.82)	VTSPSEANvVVAVSTGQrTGSrPA..APPKP
  920-  947 (43.22/20.91)	VNSVSTGN.VNSVSTGN.AGT.PAsvAPDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.94|      11|      18|     663|     674|       6
---------------------------------------------------------------------------
  663-  674 (14.28/12.19)	LRhARTEIETER
  684-  694 (18.66/ 9.94)	LR.AKEEEESNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.75|      47|      61|     135|     184|       7
---------------------------------------------------------------------------
  135-  184 (74.26/71.49)	IFDDVAEGvACMHYLKPPLL..HRDLKVENVLISRASASVCYKLCDFgsAAP
  198-  246 (80.48/63.95)	IEDDVQRH.TTLQYRSPEMIdvYRKQPIDEKSDIWALGVLLYKLCYY..TTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.06|      15|      17|     252|     267|       9
---------------------------------------------------------------------------
  252-  267 (24.32/20.21)	QMAILNASFkFPPYPQ
  271-  285 (24.73/15.10)	QLKLLIATM.LKETPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.80|      15|      34|     609|     629|      10
---------------------------------------------------------------------------
  609-  629 (19.73/24.57)	VTRSKSANAAKvrpvsvHAGG
  646-  660 (26.07/15.15)	VVRTTTAAAAN......YEGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.38|      14|     672|     360|     376|      13
---------------------------------------------------------------------------
  341-  354 (26.10/11.91)	PPMQETRIIPEIAP
  363-  376 (25.28/ 7.38)	PSSQQSSAKPSPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.30|      63|    1008|      44|     117|      14
---------------------------------------------------------------------------
   44-  117 (94.91/91.84)	PQPVDDVDTAvlkRvaVPDKMAlanmRTEVETMKK....LKGHR.HIVTYIDSHASQLRGG....GYEVFLLMEYCdgGGLID
 1058- 1129 (94.39/62.25)	PEIIDYVDAS...R..NPDIYT....REFVELVQRgnqdLKGKQaAFASFRDVLAREMRGAmpecTHEVNRAVEAT..GGVID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11214 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGEAFRRFESSGSGSDSNKARTPSPDETAVPARQPTPDMREGGVGSSGGNDLPMVEDETAEPEDDISPEMRRELERRRLSQEEKRVAQAAADYRRRVAAGGGGGGGGGGGAGMRSASIQNKVQSLLQDHSNKPPPPKTATGYGRYTEEAAVTSPSEANVVVAVSTGQRTGSRPAAPPKPKKLQAVNVNSVSTGNVNSVSTGNAGTPASVAPDSPDWETSFSRRFP
2) ILHEKGDKFDFEPTLADSKATTEDEDLARRLTNALADDAFVKLSSPDSKPSVRDQPSVRESSSHRRPQTSPMETRDSPQQKWQQQQQTPLYQPVPQKPSMVSTGTMTSPPSTPKQPQPSLLSSRPIYRFPPSESTSSTAADHRASSQPQPSPRTSAEKIAGLSGSARPSLETSRPSTLDLLGTVDHDPVTRSKSANAAKVRPVSVHAGGMRERSREPDTTRSSIDVVRTTTAAAANYEGGAPLRHARTEIETERSQIVSDVDYLRAKEEEESNRKREKRYSSNGGVGGGAKHIKRTSLSNLS
3) TRIIPEIAPMRRGRPSKPSSQQSSAKPSPSPYRGSTDPFAALDGHSTKGAATATTTTSVKTDEISARFPTLDQF
734
421
346
958
722
419










Molecular Recognition Features






MoRF SequenceStartStop




1) ADYRRRVAA
2) PIYRF
3) QNKVQSL
4) RFGEAFR
5) YGRYTE
824
545
852
733
875
832
549
858
739
880