<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11201

Description Uncharacterized protein
SequenceMIPHSSAGVQPWDHPLRALNNGAARVENVQGPPQVADLPTARLPAQSQLRQPVIVDLTASGPDSQEPPSKRQKLDTPAAPTSGDPHITPSTADQKNGTLAAAGSRPTALSWRGRPAWSFQALISETYGAGSQGEGQQQEAKSASSPPPFPVLPANLSLPEAGGGDPVGSREKSPDQEVKTTPYRIKVPLVAPTLKGEKVADFSPWNGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHNMVTAPSTFKPPPRVTLTDNKREAWLRDLANPAVPLRRLSRTIPHGIRGKLLLDQCLSKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAVGLEVKWVRDWTTSVQQFIEGVLSTCGKADWKVKMTYAVSLTSRLFFEHLLDHDHYLEWMLSSLEAASTNALPLWLLMLGIYWDNIMQYRKRGRRLTEILLQKLQQVTKSKQAGPLQPLVDRLSHCIKRIVHEQTSSAVLPNCWDTFKETVASCLDLNENVNRSIFQSLSERNARVQYPKDPRCKTQYPSQQRIIRYLDSVRSTHDIQSISSACLDTVEDKALLVFKLLEWSATPFRSGLCRVYTAVRLLRKWKISGVDVDSHILAFLRGAAGNVRIDANNIYHVISELVRSQTFSVGKYLQWLMAKGVAKDSDETQSTGKLSDAQLLAQLPVSRLLEHVRNLRNTLLDRVGISALEESRMIEHVRACVAQRLPHMFDSGLADLKHTELVPVSLTWAVKSEIGQWLRRAVAQHYQSGGARAPGSRRSFSGSLEVSALTPEEFYTVRDLFETFGDLSMLADVLHHASNSGDPIVLASAADTLNYHYDSFTVIGATTDLFRRLVEASARLKNMGITSLDLVFSLIELGLRLPTESSTVTLLRQELARMENRSALAVPSPLSDNVPDALHGSDPSFYDKLEQLLLSGTGLDEFTLNTIFQSLVKKLECGDLGGELSPNEICRRLAHLRSFNPKHFDILLVRWVCTILKSPTRPSLRHILVPLIGVGCVTIQAFISLARKMSKAETATASLPDLAGLQLDILELLVSPTQETPKFYDLVDYRFRLARQEFLSKHVQEILVIAHESAVAITQQNAGLDTDTRRAKFKSYMTILLRHVLISDPECVGQDHMQRLLDQHPEATVALQHALDLLLGLDASGSDCKSSLAEANQLIDMTNDFSLPFCQLKLQSLFNTNTEDGVRAGIVDMMFKAAVADSRAKSSHWVDLVALMNRDAIQQIRERAERGFFSITLPSDHTNEDSSGPIENITSFEAARVYLKVIEDLAYSIPDHGVSHVAPMLVEKLDQLLHRLITTQTNFRSIVGSRDAMLTEQIIQSRSNVERAFAFWFSALLRMVVIHRQAFHTNAVSEQSRLLVSIISIAFARFPDKVLRMFPSAGYFPRHGQDENNRPCPGVLLQTHALDVAASLIDTFPDEARHQCARMLKEKCPPFIHFQKDPRFLYLLGPAMDGSLINLSQLASLPSPAASGSTPTPGPSGNTLMAPAPSHQQPCMSSSSSSVLSENSVFMANRLHLQQRGRVVGPYPIRPWELLGDAAPILGANDTAIGLGLFEARRVRV
Length1588
PositionKinase
OrganismPenicilliopsis zonata CBS 506.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicilliopsis.
Aromaticity0.07
Grand average of hydropathy-0.207
Instability index49.55
Isoelectric point8.63
Molecular weight175922.07
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11201
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.96|      34|      35|    1333|    1366|       2
---------------------------------------------------------------------------
 1319- 1340 (34.51/20.89)	LLHRLI.TTQ...TN............FRSIVGSRDAM
 1341- 1374 (59.95/42.32)	LTEQII.QSR...SNVERAFAFWFSALLRMVVIHRQAF
 1375- 1404 (26.49/14.14)	HTNAVSeQSRllvSIISIAFARFPDKVLRM........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.83|      27|      35|     130|     156|       3
---------------------------------------------------------------------------
   94-  118 (34.93/15.57)	..QKNGTLAAAGSRPTALSWRGRPAWS
  130-  156 (45.85/22.69)	GSQGEGQQQEAKSASSPPPFPVLPANL
  168-  194 (41.04/19.56)	GSREKSPDQEVKTTPYRIKVPLVAPTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.86|      11|      23|     690|     700|       4
---------------------------------------------------------------------------
  690-  700 (20.26/13.14)	LPVSRLLEHVR
  715-  725 (20.60/13.49)	LEESRMIEHVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.27|      30|      35|     359|     388|       5
---------------------------------------------------------------------------
  359-  388 (50.70/33.00)	AVGLEVKWVRDWTTSVQQFIEGVLSTCGKA
  397-  426 (49.78/32.26)	AVSLTSRLFFEHLLDHDHYLEWMLSSLEAA
  646-  664 (19.79/ 8.05)	.....SELVRSQTFSVGKYLQWLM......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.30|      23|      38|     579|     603|      10
---------------------------------------------------------------------------
  579-  603 (36.88/30.48)	DKALLVFklLEWSATPFRSGLCRVY
  620-  642 (39.42/25.85)	DSHILAF..LRGAAGNVRIDANNIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.90|      55|     445|     742|     831|      11
---------------------------------------------------------------------------
  765-  831 (72.98/87.84)	LRRAVAQhyqsggARAPGSRRSfsgSLeVSALTPEEFYTVRDLFET.FGDLSMLADvlHHASNSGDPI
 1222- 1277 (89.92/38.14)	FKAAVAD......SRAKSSHWV...DL.VALMNRDAIQQIRERAERgFFSITLPSD..HTNEDSSGPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.68|      53|     450|    1009|    1068|      17
---------------------------------------------------------------------------
 1009- 1068 (75.79/74.16)	PSLRHILVPLIGVGCVTIQAFISLArkmSKAETATASLPDLAGLQLdileLLVSPTQETP
 1469- 1521 (93.89/69.76)	PRFLYLLGPAMDGSLINLSQLASLP...SPAASGSTPTPGPSGNTL....MAPAPSHQQP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11201 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKVADFSPWNGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPSLY
2) LISETYGAGSQGEGQQQEAKSASSPPPFPVLPANLSLPEAGGGDPVGSREKSPDQEVKTTPYRIKV
3) MIPHSSAGVQPWDHPLRALNNGAARVENVQGPPQVADLPTARLPAQSQLRQPVIVDLTASGPDSQEPPSKRQKLDTPAAPTSGDPHITPSTADQKNGTLAAAGSRPTALSW
197
122
1
242
187
111










Molecular Recognition Features






MoRF SequenceStartStop




NANANA