<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11200

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGMIMDKGSAVKPRLNENAHEASNGVASSTNHGEKIRNIRGPNNGSIRADEKVGENGAVHRFRDQSTLSLPRPELEHITHGFFPFAQLVSRSAQKCWNDLSDLITELADMQVTTQDQASSSPTVGGKLTGAQSPGNVEKKLQLLNFAHRKRGEFIKLLVLSQWSRQSSDVSKLIDLQGFIRTRHMTYNAAIQCVGDMKIDLVRAQVANPDLNTALEILFRGGISSMPDLGYDLPKPLTAKKTLKKLQKINRLISARLALHSIIPQCFQTYRIHDGRVTFFVPGEFELDLSIGEESATSQFFFVDIRFNFSPSSPIPKGRLLNELDIKINEILRDGNLTGCFNYLHGLVLTNKVNVLFKQAAELSRGAWSESLRVELLHRTLVLHYWALRPGAKSWIEVGIKRGRSENHIDTNLPPGTPYIGLRWMRDGKIVDSKNVRFNMENLSMEDILRSVIALHISHILHTAYSKLIATSLFASRALSLRGQLSGIEPGDCRLDVQLTVSKHLRVSIEPASGAIILSAIPTTLDRFETVRNPERSASDAIFSRVSRIRCIAAMEEVECDVKMLGLEVIGPKGLRLDIRRIFFPPVLRVSFFSHRSWGRDWIAAATSSMDGDHWWVVQLQSAVAISSRPASDTDAQGSSILPAAQMISKAPIATQQGPGATSFADLGLCLSGMIAVHANVRFLAEMEIPFSPPLSKLQVGPHLEIPDVIIRYNVSKLPLPLCIVIPTGLRRMPLIKDAVRLVFGGLDAQSESVTFVAYGQLARPIIPLNKLALKPDHSLVFKRNSTSFAMRLSTHAGQSVIVELLERLQRLEYALAIVESLHQRRIPIYSFSLSRISFGYSTQKDLLARIHIQTYESSGVAHDPVNLKSRTEPLFRTSLDIHFDHPNPHRRIQESLSSILNQDAAGAGFQTVVELLPITFPLLQALDSITSIRDRLRIHVTVRNAKTYVISYPRYNFRFLLTAKQHFSRVHWILKEMEKSRNRSDQDQLVSCLQERLYRGRGDGWKGLGNGAIVDYDKAGNLLTALDACFRSMPELSDVNAPSGQASMGFGVATKQNAPGIPDTPGGLGNHAPKSIQDTSIITID
Length1087
PositionTail
OrganismPenicilliopsis zonata CBS 506.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicilliopsis.
Aromaticity0.07
Grand average of hydropathy-0.141
Instability index41.43
Isoelectric point9.43
Molecular weight120709.40
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11200
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     370.17|      90|     382|     302|     391|       1
---------------------------------------------------------------------------
  302-  383 (134.68/71.51)	........FFVDIRFNFSPS.SPI.PKGRLLNELDIK..INEILRDGNLTGCFNYL.HGL.......VLTNKVNVLFKQ.....AAELSRG...AWSESLR.VEL..LHRTLV
  384-  461 (92.35/46.98)	LHYWALRP................gAKSWI..EVGIKrgRSENHIDTNLPPGTPYI..GLrwmrdgkIVDSK.NVRFNM......ENLS......MEDILRsVIA..LHISHI
  684-  768 (101.12/52.06)	........FLAEMEIPFSPPlSKL.QVGPHLEIPDVI..IRYNVSKLPLPLCIVIP.TGL...........RRMPLIKD.....AVRLVFGgldAQSESVTfVAYgqLARPII
  770-  809 (42.01/17.80)	LNKLALKP................................................dHSL.......V........FKRnstsfAMRLSTH...A.GQSVI.VEL..LER...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.76|      23|     118|     831|     853|       2
---------------------------------------------------------------------------
  831-  853 (40.57/24.37)	YSFSLSRISFGY.STQKDLLARIH
  950-  973 (39.19/23.32)	YVISYPRYNFRFlLTAKQHFSRVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.97|      22|      72|     125|     153|       3
---------------------------------------------------------------------------
  125-  146 (36.10/16.69)	VGGKLTGAQSPGNVEKKLQLLN
  230-  251 (33.87/ 8.97)	LGYDLPKPLTAKKTLKKLQKIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.93|      42|     118|     473|     514|       4
---------------------------------------------------------------------------
  473-  514 (69.20/43.08)	SLFASRALSLRGQLSGIE...PGDC...RLDVQLTVSKHLRVSIEPAS
  542-  580 (46.55/26.53)	AIF.SRVSRIRC.IAAME...EVECdvkMLGLEVIGPKGLRLDI....
  592-  633 (64.18/39.41)	SFFSHRSWG.RDWIAAATssmDGDH...WWVVQL..QSAVAISSRPAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11200 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGMIMDKGSAVKPRLNENAHEASNGVASSTNHGEKIRNIRGPNNGSIRADEKVGENGAVHRFRDQSTLSLP
1
72










Molecular Recognition Features






MoRF SequenceStartStop




NANANA