<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11199

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMASEQWRTFLHRCLMHRIDATEFRDLSKLLFSKCSISETNLIDALLECRAATGVKWDPLLPLYIDCLCKMGKVNPSTVLGSLLKHSSIHDKPQSPSTPAKKQQKCYTLMTDIRVVQDVMLSISTGNTPQTLAEAINIFSAVVEWIQAVISWHNSHVDQNQQTGGLMSSPDVVSLFESLGILLAALSGTGKGLDVLSSHSHESVKIKLGQALTAYVPLCVEVSLPLRNRLDSLQKEFNLYGEPASKTLDVSMMEGVNVNALQFEASVMDGAVINSRAGLYIYINAMLVGRPLVDDTLLINYLTNRHGGHYEALIEEITTAAFDVLSNAMYRNESSRTMFVFRSFLVNKLPAFFAAMLAASMVTIPMEMCISHALSRLDPNTFPSFSQMFSMQSNTVLSDVRQEFLFACALHRLIPESSIERLLGENPMQTLPTGGQYIKDELVSQINNSPERTEQLINEIESMEGNAGAIVGAITEVIHNLCNQKETMTLKNICNSLSRRPQALDVILLFRGTRQVLQPLCTLLDSWHWDADEGENQPVYDEFGSILLLVLAFKYRYDLRPYDLGISSNDSFILRLLERGSCTRKLEDLDEKQNKNLGTWIAALFIAEGISEETMSACSPHEFYLLVTTLFNQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALAWLGNHIWESDSDPSIPLKTLQSLVTPSSISGEGKAIHRTVLQIAARNLEEQLKDVRANHPNRTDIKPILDALEPYLSFQRVGSSRKSELESWTTSSGGGLLGSIRNTFQSLVLWSTNPDISMAPHSYTHRQLIAGVRLLGSVRVLRGLIEELKMQSEGGSGDIALDVAATMICAPMAESFDIDPTDQVEPKQEPLPRCPILTLRDALVLQHQSVPRISEKDPLRAEVIVRLYRRVNALSSPPSQVPNLDVSNIIHNMQLGVEGSGQMELEPPAQEPGNGVGEVDIHQMLDKATAAAAAGYDGGVGVGQEMGLEGGMDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1013
PositionTail
OrganismAspergillus wentii DTO 134E9
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Cremei.
Aromaticity0.06
Grand average of hydropathy-0.046
Instability index47.08
Isoelectric point4.98
Molecular weight111600.46
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11199
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.06|      79|     300|     348|     540|       1
---------------------------------------------------------------------------
  449-  533 (127.68/197.64)	PERTEQLINEIESMEGNAGAIVGAITEV.IHNLCNQketmtLK....NICNSLSRRPqALDVILLFRGTRQVLQPLCTLLDSWHWDADEG
  684-  767 (123.38/35.05)	PLKTLQSLVTPSSISGEGKAIHRTVLQIaARNLEEQ.....LKdvraNHPNRTDIKP.ILDALEPYLSFQRVGSSRKSELESWTTSSGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     333.65|     111|     478|      74|     203|       2
---------------------------------------------------------------------------
   74-  203 (154.16/147.82)	NPSTVLgSLLKHSSIHDKPQSPStpaKKQQKcyTLMTDIrvvqdVMLSISTGNTPQTL.AEAINIFSAVVEWI..QAVISWHNSHVDQNQQTGGL..MSSPdvVsLFESLGILLAALsgtgkGLDVLSSHSHESV
  568-  683 (179.49/115.35)	NDSFIL.RLLERGSCTRKLEDLD...EKQNK..NLGTWI.....AALFIAEGISEETMsACSPHEFYLLVTTLfnQSLGACEAGKLEFDTLKGGFeyLLEP..F.LLPSLVVALAWL.....GNHIWESDSDPSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.88|      33|     673|     216|     255|       3
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  216-  255 (52.82/51.76)	PLCVEVSLPLRNRLDSLQKefnlygePASK..TLDVS.....MMEGV
  890-  929 (48.06/31.11)	PLRAEVIVRLYRRVNALSS.......PPSQvpNLDVSniihnMQLGV
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.47|      16|     391|       3|      18|       4
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    3-   18 (32.49/22.53)	SEQWRTFLHRCLMHRI
  397-  412 (28.98/19.30)	SDVRQEFLFACALHRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11199 with Med5 domain of Kingdom Fungi
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