<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11189

Description Uncharacterized protein
SequenceMAYHSQSPFSGHIPAYNPVAAMTAPAGTFLPGTKVQVGSHRVVVEKYLSEGGFAHVYVVRLPQPVDGVNTAVLKRVAVPDKSALANMRTEVETMKKLKGHRHIVKYIDSHASQLQGGGYEVFLLMEFCSGGGLIDFMNTRLQNRLTEPEIIKIFSDVSEGVACMHYLKPPLLHRDLKVENVLISRQGSTSYYKLCDFGSTAPPRPAATSGAEGRLIEDDVQRHTTLQYRSPEMIDVYRKQPIDEKSDIWALGVLLYKLCYYTTPFEEVGQMAILNASYKFPSYPPFSARLKMFIASMLKENPQKRPNIYEVIREVCLMQGKEVPIRDIYSGRSTSEARRYQELPPSPTEAPQIGAVFSPPVQETQIIPEIAPMRRGRPARPDTSQHNSAKPSPSPYRGSTDPFAALDGKSRGSTEEFANRFPSLDQFQILHEKGGKFDFEPTVAENPEDENLSQRLTNALADDAFAKRPSSEDEPVRESSINRRSQIPSSSDVKLAQPRNTREESRQQTPLYQPVPQKPVMVSTGTMTSPPATPGLPDLNLPARPPIHRFPATEHPRHTSNNPWADETEKRPPVPSKDPSPTVPSFKAEPNPRTSADRISNVSASARPSLETVRPSNLDITDPMTGRSKSANAKARPVSVGAKYDIPRESGSTRSSLELPRPPYDAGAPLQHARTAVDREYERGNISSDVDYLRAREEEEQSRKKEKRASGSSKHTKRSSLSNLSFSGTKTIFAGRFGDAFRRFESSNQDGKSKTPSPEDTPKLPTTIMTEEVAEPGIIEGFEEDEEDISPEMRRELERRRLSQEERRVAEAAAEYRRRAAERGEGGWRPGGDGTRSAVIQNRVQSLMGDTNKPLPQKTATGYGRFTDEASETSPALQAKQTDARVVYGTPTGRTSPVKEGWGAREAPQQTTGSTGYVAAQDSGPRPSLPTRPAVAPKPALPPKPKNLQSGVTGSQGNSPTVQETPTGVNEDWESNFSRRYPSLSGLEMVETEIEIPKVASMRTKEDIIQHLFEIQSAVHGYLGPETQQELVRKIKTLTVALSTLSTHTSQPPSQEPQDNNNSNDPLISNIHLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKKEAFAGFRDVLAREMKSAMPECGGEVERVMERTRSA
Length1144
PositionMiddle
OrganismAspergillus wentii DTO 134E9
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Cremei.
Aromaticity0.06
Grand average of hydropathy-0.747
Instability index62.56
Isoelectric point7.66
Molecular weight126678.48
Publications
PubMed=28196534

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11189
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     396.45|      61|      61|     514|     574|       1
---------------------------------------------------------------------------
  514-  567 (88.03/36.45)	....................P........V......................PQKP.VMVSTGTMTSPPATPGL....PDLNLPA.........RPPIHRFPATEHPR..........HTSNNPWADE
  568-  633 (49.79/17.40)	TEKRPPVpskdpsptvpsfkA........E......................PNPR.TSADRISNVSASARPSL....ETVR.PS.........NLDITD.PMTGRSK..........SANA......
  634-  692 (46.69/15.85)	..KARPV.......svgakyD........I......................PRESgSTRSSLELPRPPYDAGA....P.LQ.HA.........RTAVDR....EYER.........gNISSD..VDY
  693-  760 (59.99/22.48)	LRAREEE.............E........Q......................SRKK.EKRASGS.SKHTKRSSL....SNLSFSGtktifagrfGDAFRRFESSNQ.D..........GKSKTPSPED
  761-  811 (50.13/17.57)	T...................................................PKLP.....TTIMTEEVAEPGIiegfEEDEEDI.........SPEMRR..ELERRR..........LSQEERRVAE
  814-  881 (48.60/16.81)	AEYRRRA....aergeggwrPggdgtrsaV......................IQNR.VQSLMGDTNKP.....L....PQ...KT.........ATGYGRF..TDEAS..........ETSPALQAKQ
  882-  964 (53.21/19.10)	TDAR..........................vvygtptgrtspvkegwgareaPQQT.TG.STGYVAAQDSGP.R....P..SLPT.........RPAVAPKPALP.PKpknlqsgvtgSQGNSPTVQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.33|      36|      62|      13|      57|       2
---------------------------------------------------------------------------
   13-   57 (52.58/68.43)	IPAYNPVAAMTAPAGTF..LPGtkvqvgsHRVVVeKY.......LSEGGFaHVY
   78-  122 (54.75/41.86)	VPDKSALANMRTEVETMkkLKG.......HRHIV.KYidshasqLQGGGY.EVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.15|      33|      43|     306|     347|       3
---------------------------------------------------------------------------
  306-  347 (51.67/41.02)	PNIYEVIREvclmqgkevPIRD.........IYSGR.STSEARRYQELPPSP
  351-  393 (48.47/23.27)	PQIGAVFSP.........PVQEtqiipeiapMRRGRpARPDTSQHNSAKPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.53|       9|      73|     890|     902|       4
---------------------------------------------------------------------------
  890-  902 (14.86/14.53)	TPTGrtspVKEGW
  965-  973 (20.67/ 8.73)	TPTG....VNEDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.44|      16|     694|     400|     418|       5
---------------------------------------------------------------------------
  400-  417 (23.79/19.21)	TDPFAALDGKsrGSTEEF
  424-  439 (29.64/12.74)	LDQFQILHEK..GGKFDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.36|      17|      20|     256|     273|       8
---------------------------------------------------------------------------
  256-  273 (29.39/19.54)	YKLCYYtTPFEEVGQMAI
  278-  294 (33.97/18.39)	YKFPSY.PPFSARLKMFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.20|      25|     553|     441|     511|       9
---------------------------------------------------------------------------
  217-  241 (46.50/ 8.29)	EDDVQRHTTLQYRS..PEMIDVYRKQP
  472-  498 (38.69/15.52)	EDEPVRESSINRRSqiPSSSDVKLAQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11189 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGDAFRRFESSNQDGKSKTPSPEDTPKLPTTIMTEEVAEPGIIEGFEEDEEDISPEMRRELERRRLSQEERRVAEAAAEYRRRAAERGEGGWRPGGDGTRSAVIQNRVQSLMGDTNKPLPQKTATGYGRFTDEASETSPALQAKQTDARVVYGTPTGRTSPVKEGWGAREAPQQTTGSTGYVAAQDSGPRPSLPTRPAVAPKPALPPKPKNLQSGVTGSQGNSPTVQETPTGVNEDWESNFSRRYP
2) TQIIPEIAPMRRGRPARPDTSQHNSAKPSPSPYRGSTDPFAALDGKSRGSTEEFANRFPSLDQFQILHEKGGKFDFEPTVAENPEDENLSQRLTNALADDAFAKRPSSEDEPVRESSINRRSQIPSSSDVKLAQPRNTREESRQQTPLYQPVPQKPVMVSTGTMTSPPATPGLPDLNLPARPPIHRFPATEHPRHTSNNPWADETEKRPPVPSKDPSPTVPSFKAEPNPRTSADRISNVSASARPSLETVRPSNLDITDPMTGRSKSANAKARPVSVGAKYDIPRESGSTRSSLELPRPPYDAGAPLQHARTAVDREYERGNISSDVDYLRAREEEEQSRKKEKRASGSSKHTKRSSLSNLS
737
364
982
725










Molecular Recognition Features






MoRF SequenceStartStop




1) AKYDIPR
2) KTIFAGRFGDAF
642
730
648
741