<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11186

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSFNLPLRPLIDKRDRPDSLPVEIAQINAQYGSFRDVNEASLRAKIQEEKEKDGVLDEDEDDKSTADLDTTERQELLYKRRAEITQFALQAHMETMFALDFVSLLISKNAPRQAETSMSAYLKSVAPLGSLNAEVVNPPPKPESSEGDTKTVSRGWRLQNFDAAANKLLNSATRLEAEVASETRYWNEVLAVKDKGWKVCRLPREQQSLGVQYGFLEATPLFRDRGLASLRRADDGSLILDKGLIPPKARTVRVRVKESGRFTGCSKLQNPVLNGEDSIESRILQARDTVYEEELFHELVREARVIAKQGVTTRQNLIQFAVSDEQEIMLDLVDVNQDSANDEQESHEQDVLADALAYSIRILLAYAHRQNLRRRTQVPPPLTPVRRHALEYQLLRPIMAYLQHSSQVRWLESFVKDIYRVLKSAGITCDYTSSLFSSVNLARKKGLPQVEALVEGFLVPLESTLSANLVTPQSSFNVKIRTNLSPPASGTQFDVSVNLPRHPDTQPPARIGLRDEAAAVITHFVMLDVVSAISSSHPKPSPGAGESATWEAAYPHHGELLTLSPKTGKQKKMKVMLSRHEMTIQVYEMRGIERLGRSATDKEPSLQSRTWKSDPVVPAQSSLMDFVAEVSKE
Length635
PositionHead
OrganismAspergillus wentii DTO 134E9
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Cremei.
Aromaticity0.06
Grand average of hydropathy-0.455
Instability index49.26
Isoelectric point6.15
Molecular weight71131.76
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11186
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     203.68|      59|     105|     131|     192|       1
---------------------------------------------------------------------------
  131-  192 (92.58/66.38)	GSLNAEVVNPPPKPESSEgdtKTVSRGWRLQNFDAAANKLLNSATRLEAE.......V..ASETRYWNEVL
  197-  234 (22.95/ 8.14)	.........................KGWKVCRLPREQQSLGVQYGFLEATplfrdrgL..ASLRR......
  238-  298 (88.16/55.33)	GSLILDKGLIPPKARTVR...VRVKESGRFTGCSKLQNPVLNGEDSIESR.......IlqARDTVYEEELF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.99|      31|      32|     481|     511|       2
---------------------------------------------------------------------------
  481-  511 (55.24/36.94)	KIRTNLSPPASGTQF...D.VSVNLPRHPDTQPPA
  512-  546 (39.96/24.60)	RIGLRDEAAAVITHFvmlDvVSAISSSHPKPSPGA
  559-  582 (29.79/16.39)	HGELLTLSPKTGKQK...K.MKVMLSRH.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.18|      16|      32|     353|     368|       3
---------------------------------------------------------------------------
  353-  368 (26.47/19.27)	VLADALAYS.IRILLAY
  387-  403 (25.71/18.50)	VRRHALEYQlLRPIMAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.96|      19|     135|     302|     343|       4
---------------------------------------------------------------------------
   83-  101 (32.92/11.52)	RAEITQFALQAHMETMFAL
  316-  334 (32.04/30.27)	RQNLIQFAVSDEQEIMLDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11186 with Med17 domain of Kingdom Fungi
Unable to open file!