<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11184

Description Uncharacterized protein
SequenceMIPHPSAGVHPWGHPLRAVNSGSGRVDVSQGLNQSDFLPEKPSMPVPQPQTRSPAVIDLTTSSQDAQEREPPAKRQRLDVPSGSAIGDASPVPVGGGELKNTAGSASSRPPTVPWRGRPVWSFQALISETPGGGEVHGETTAALAQGEKPASLPPFPTMPWKHTPPDSSGSTRSRESSPVKDVQTTPYRIEVPSNAPALKGDKVADFSPWTGNHPEDVLNEHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSMVTNPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLSKLIPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTTNVQQFLEGVLSSCGTTDWRMKVTYAVSLTARLFFEQLLDHDNFLGWFLSSMESARLNTMPVWLLMLGIYWENIMRYRKRGRRLAELLLQKLSQAIKSEQAASLQPLTDRLSLCIKKLVLEHTSSAILPASWGSYKDLVSSCLNLEENVDKTIFQHLAERNARVQPPKNCQLTAQHSPQQRIIYLFDSMRFTHDISSISAACLTSVDDRTALVSKLLEWTATPFRYGLCRVYAGVRLLRKWKMSGVDIDFHILAFLTEARGDAQLNMGNIYHAISELVRSQTFSVGRYLQWLMAKGVTNSPQVDQHTSISGEVGLLAQLPVSRLPEHVRNLRHTLLARAGVSTLEEASIIASVKASISQHLPNIFGVDVHNIVPCDLSQPNLTWAVKYEIGQWIRRGVNEHCRISNRNIPGVDLSADMKVSALTPSEFYHIRDILESFGDLSILADVLKQAANCDDNTVLASAADTLNYHFDSFCIIGATTDLFRRLVEAYARLKRLGTTSLDLVFSLIEVGLQVPNESNTVALLRQDLSRIESKSALAAPSPLSDHIPEIFSESDPLFHEKLNQLLSSGSGIDESTLDTLFNALTRILLSDDQGKLTRNDACRYLAHLRPFYPKHFDAMLIRWICCALKSATRPSLSKILPPLIGVGCVTIQAFVSLVKRLSQSETMGPTIQDIAALQMDILELLIPPSQEQRRYCDLVTYRFHLAQQEFLVKYPEETFGIIHDAAASMSAQNLESESNPRRSDLANYMTILLCDLLTQHPERAAKYCTQKLIDQHPASIVALQKALDFLLGFDTPTDPGSNMSEAERVISMTNDFSLPFCQLKLQVLFNAESGEEIGNGIVDVMFKAAVADSRAKKSNWAGLVSLMSQSAVRQIRERAEKGFFSVPLFENSADDHSSSTADNSSSLETAKLYLTIIEELAYSIPEAGVSSIAPILVEKMDFLLHRLIIMQTNFSNFAENRHGVAADKAIQSRSNFERTLAFWFSALLKMVVIHRSAFNTSPSLAPKPNSLQDQSRLLISIFCISLSRLPDNALRLFPTANYFPHPVQPESYRPCPGILLQTHALDVAASLIDTFPDEARHQCTRFLKEKCPPFLQHQNDSRFLYLLGPVADTTSLNPSQPASAPSPAASGSASTPTPSGNLPGGTSALQQPVAPLSGMSETSNCVASRLRLQCRGRVIGAYPVRPWELLEDAAPIMGANDTAVNLGYFDARRIRA
Length1593
PositionKinase
OrganismAspergillus wentii DTO 134E9
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Cremei.
Aromaticity0.07
Grand average of hydropathy-0.197
Instability index50.55
Isoelectric point8.14
Molecular weight175882.68
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11184
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     270.91|      99|     313|    1062|    1183|       1
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 1062- 1110 (61.45/59.68)	..................................................................................LIPPSQEQRRYCDLVTYRFHLA.QQEFLVKYPEETFGIIHDAAASMSAQN
 1133- 1183 (62.55/31.31)	LLTQHPERAAKYCTQKLIDQHPaSIVALQKALDFL..LG..FDT....PTDPGSNMSEA.........................................................................
 1448- 1578 (146.91/80.70)	LIDTFPDEARHQCTRFLKEKCP.PFLQHQNDSRFLylLGpvADTtslnPSQPASAPSPAasgsastptpsgnlpggtsalqqPVAPLSGMSETSNCVASRLRLQcRGRVIGAYPVRPWELLEDAAPIMGAND
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     723.30|     168|     322|     219|     391|       2
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  219-  371 (239.94/157.36)	......................LNEHTAKQGH..YDRTQVSQNESNTAR.PSLYAQLKHRSGLQM..........LSSVFAAAL...EKRQNHSMVTNPSTFKPPP......RVTLTD...NKREAWLRDLANPSVPLRRLS.RTIPHGIRGKVLLD.....QCLSKLI.....PVGRAV.WLAKCVG..ANEIRAFKRKGTSGALAIGLEAKW
  372-  508 (165.22/115.10)	VRDWTTNVQQFLEGV..................................................lsscgttdwrMKVTYAVSL...TARLFFEQLLDHDNFLGWF......LSSMESarlNTMPVWLLML...GIYWENIM.RYRKRGRRLAELLL.....QKLSQAI.....KSEQAA.SLQPLTDrlSLCIKKLVLEHTSSAI...LPASW
  511-  695 (195.82/127.95)	YKDLVSSCLNLEENVdktifqhLAERNARVQP..PKNCQLTAQHSPQQRiIYLFDSMRFTHDI.............SSISAACLtsvDDR..TALVSKLLEWTATPfryglcRVYAGV...RLLRKW..KMSGVDIDFHILA...FLTEARGDAQLNmgniyHAISELVrsqtfSVGRYLqWLMAKGV..TNSPQVDQHTSISG..EVGLLAQL
  697-  801 (122.32/76.63)	VS...................rLPEHVRNLRHtlLARAGVSTLE....E.ASIIASVK.ASISQH..........LPNIFGVDV........HNIV..PCDLSQPN......LTWAVK...YEIGQWIRRGVNEHC...RISnRNIP.GV..DLSAD.....MKVSALT.....P.......................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.03|      36|      36|      71|     106|       3
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   25-   66 (28.98/14.10)	......R.VDVSQGLNQSDflpekpSMPVPQPQTrspaviDL..TTSSQDA
   71-  106 (64.34/41.96)	PPAKRQR.LDVPSGSAIGD......ASPVPVGGG......EL..KNTAGSA
  110-  145 (48.72/29.65)	PPTVPWRgRPVWSFQAL........ISETP.GGG......EVhgETTAALA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.53|      19|      21|     930|     948|       4
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  930-  948 (34.34/18.98)	ES..DPLFHEKLNQLLSSGSG
  951-  971 (28.20/14.34)	EStlDTLFNALTRILLSDDQG
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      13|      21|     979|     991|       5
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  979-  991 (26.19/16.23)	CRYLAHLRPFYPK
 1003- 1015 (22.03/12.34)	CALKSATRPSLSK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.65|      16|     147|       3|      23|       9
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    3-   23 (26.87/26.48)	PHPSagvHPWGH.PlrAVNSGS
  155-  171 (32.78/16.92)	PFPT...MPWKHtP..PDSSGS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11184 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHPSAGVHPWGHPLRAVNSGSGRVDVSQGLNQSDFLPEKPSMPVPQPQTRSPAVIDLTTSSQDAQEREPPAKRQRLDVPSGSAIGDASPVPVGGGELKNTAGSASSRPPTVPWRGRPVWSFQALISETPGGGEVHGETTAALAQGEKPASLPPFPTMPWKHTPPDSSGSTRSRESSPVKDVQTTPYRIEVPSNAPALKGDKVADFSPWTGNHPEDVLNEHTAKQGHYDRTQVSQNESNTARPSLYAQL
2) SLNPSQPASAPSPAASGSASTPTPSGNLPGGTSALQQPVA
1
1492
250
1531










Molecular Recognition Features






MoRF SequenceStartStop




1) GRPVWSFQALI
117
127