<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11180

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGNITNIRVIDGFSNIYWRIYTEEPGITNYSAETPANGFTILKHLSRLKDIELRLRNLDCLASCYPRRLGLWVFSATPNFEGLSPLCLNESKDDSSRLLIGSTTLKVSASGNTTSQDLVRTLSAEPQPPNGGAAGPQRAQNAPNSSRRTDGYANFAAIHASFISAVTGAISLQLIRRHNAIPLGSRTLFTAIEIDGYESPKIINDSPASISSLTTVQIQLTSVGKLTVSLQTIAQAGIARLYSPRNQPAEIADAQSGMDLWLSPNGTIARLVNSNTNLQNSSPFPSGMWGTSSEGSLGTSATKRKQWKLNVLEWLGNSGLQVNSIEDEPWVEVEVWEPFYARLSGEILRQNEQNPSVLPLKRILWPARYCFKRTRSPTARHTNETQDFCPFADDPLEFAEKWYVMAIPGDEASFKPQIGHEEPPKGQEMSPFRIDPPDGIESLSRIAHYPDLQTASLVYPTPPDGAVAVGPNSINPTDVFAEDPDSGLSQVQNQVKQNIHDQVSSKHRPGSDLTMDFGPAAGLVVGSGLYDTNDDDDLFGEMNDKDFGSKGITDADFSFFDDPGFDMGGDTLAGDIQEAPSIAVDLEEPRAQSTADADNELPEIPMEEIPAEPVDEIPASPKDLATNLDDKQIASDSNDHGPSPQNENSQTMSPPLSPVEVKKILFSGSNENDPSVKEARKHSHYNPVNFQQNIGNWNQKYGAEGKFWFSGTEKSGAANSTNSTSDIPTIGLPQRSVKAKAMAESSSGTNSHETPSSGLKQSLHSDSDSNSDSSDDSDEIISEGGLSPIPAASATLKRKRAGSNSETSHALSPARPPIDAGQDINTSKLEDSTFLGNFLSTFSDWSLTGYFSASQAQIMPVLVRKDEYIQIAQLLVDQVTQSSLNHKLDGQVGLSDLETEAFSLRTFLEDTDFIGEIERLDLKGYVSLQDMSPSPPASDGTISRQTPQRKETTKGSISRLSAPHLRIRRDKDYLEALPPAIAFWETFGLEPAHGNKNISAYCIHPHPAADAADAFLERLGLLYSSCNLGKHIRGDRSKLFERGLASWNTKSSGISGYPSVMQSLRILCEELGTAFLRSPPSKDNLVIYIINPFTHAAALADICSAFWQLFQRYVADADKTQAQQLDEIVLQVIPLGFVMSSESIVVPSQSEYLSLALEVYSRCPPDGSGASLVNCAPPVLLAEPLPRSINFKLASERLSPLQEARCLHVACSRSLDQRWITVAWSDNTGSLQRTMSYCLRFRNSNASRNVLEMRGEIWSATKSILDKIQARWRVVIVNTEPIDQEEVDTWMNLAEQYNKTRPVPLELTMLNVNTTPDLYLEPPLMPMPMSVFNQQVSSTPVATPNPSVASPDQSAATPTGSGAPANAPTPIDYPFEAETESLLTDVYDESWGVVLSHRLNSSPHLTEYRPALASGYLLRRKGPTDGDGVLPMNVNLIYTQRPSSSHESLLREILGMYRGLSTLARARGTRNVQRNTLPWHIATAIRAQELLSYVL
Length1499
PositionKinase
OrganismAspergillus wentii DTO 134E9
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Cremei.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index54.63
Isoelectric point4.97
Molecular weight163932.15
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11180
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.68|      34|      89|     986|    1019|       1
---------------------------------------------------------------------------
  986- 1019 (66.17/42.63)	AFWETFG...LEPAHGNKNISAYCIHP..HPA..ADAADAF
 1070- 1110 (47.51/28.35)	ILCEELGtafLRSPPSKDNLVIYIINPftHAAalADICSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.82|      41|      89|    1285|    1328|       2
---------------------------------------------------------------------------
 1285- 1328 (70.66/51.07)	PIDQE.EVDTWMNLAEQYNKTRPVPLELTMlnvNTTPDL.YLEPPL
 1374- 1416 (65.15/39.64)	PIDYPfEAETESLLTDVYDESWGVVLSHRL...NSSPHLtEYRPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.25|      25|      27|     729|     755|       3
---------------------------------------------------------------------------
  730-  755 (37.68/22.07)	DIPTIGLPQrSVKAKAMAESSSGTNS
  757-  781 (42.57/17.41)	ETPSSGLKQ.SLHSDSDSNSDSSDDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.52|      15|      27|     421|     443|       4
---------------------------------------------------------------------------
  427-  441 (31.90/15.95)	PPKGQEMSPFRIDPP
 1168- 1182 (28.61/ 7.58)	PPDGSGASLVNCAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.18|      19|      23|     467|     488|       7
---------------------------------------------------------------------------
  133-  157 (30.15/11.32)	PNGGAAgpqraqNAPNSSRRTDGYA
  467-  485 (36.04/24.83)	PDGAVA......VGPNSINPTDVFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.75|      16|      23|     611|     627|       8
---------------------------------------------------------------------------
  611-  627 (24.65/18.20)	EEIPAEPVDEIPaSPKD
  635-  650 (29.10/17.21)	KQIASDSNDHGP.SPQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.53|      19|      24|     521|     539|       9
---------------------------------------------------------------------------
  521-  539 (35.32/18.39)	FGPAAGLVVGS.GLYDTN....DD
  543-  566 (26.21/11.98)	FGEMNDKDFGSkGITDADfsffDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.32|      32|      90|     782|     816|      10
---------------------------------------------------------------------------
  785-  816 (52.81/32.00)	ISEGGLSPIPAAS.ATLKRKRAGSNSETSHALS
  930-  962 (51.51/23.95)	VSLQDMSPSPPASdGTISRQTPQRKETTKGSIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.45|      24|      25|     311|     335|      11
---------------------------------------------------------------------------
  312-  335 (42.85/28.98)	KLNVLE..WLGNSGLQVNSIEDEPWV
  336-  361 (37.60/18.44)	EVEVWEpfYARLSGEILRQNEQNPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      14|      15|    1188|    1201|      15
---------------------------------------------------------------------------
 1188- 1201 (23.83/16.26)	PLPRSINFKLASER
 1204- 1217 (25.81/18.31)	PLQEARCLHVACSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11180 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AASATLKRKRAGSNSETSHALSPARPPIDAGQDINT
2) QDLVRTLSAEPQPPNGGAAGPQRAQNAPNSS
3) SFFDDPGFDMGGDTLAGDIQEAPSIAVDLEEPRAQSTADADNELPEIPMEEIPAEPVDEIPASPKDLATNLDDKQIASDSNDHGPSPQNENSQTMSPPLSPVEVKKILFSGSNENDPSVKEARKHSHYNPVNFQQNIGNW
4) SVFNQQVSSTPVATPNPSVASPDQSAATPTGSGAPANAPTPIDYPF
5) WFSGTEKSGAANSTNSTSDIPTIGLPQRSVKAKAMAESSSGTNSHETPSSGLKQSLHSDSDSNSDSSDDSDEIISEGGLSPI
6) YPTPPDGAVAVGPNSINPTDVFAEDPDSGLSQVQNQVKQNIHDQVSSKHRPGSDLTMDFG
795
120
562
1334
712
463
830
150
701
1379
793
522










Molecular Recognition Features






MoRF SequenceStartStop




1) TLKRKR
2) VKKILF
3) YLLRRK
799
665
1420
804
670
1425