<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11177

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTPSAPLRTGPLSPSSPAPFTSPKDSLQPAITLDQVPQTPTSPPLMSVSAPNNASDFASMQALPNQATSQPASLSSPPSSAPMSTQTSQQPTSGITNSFPTPASSVDPDHNDKSFGTGISEAGASAPAGASVVPTQQSEDRRADHDKNLESLQTGTGVRDFAQMGGSSQVPHGDAMELDTEPSAHTNSNWPSLESLQKEFSSAFHLCKSSHIATGPDPSVDLISLYGLGPVARSVARNDPVTGEKINRLRKSYEGKLKGLGLSGRNKPVKHDPSTPGGLRQMTMWPEEEWQNQKVFGKEIKVADMDSALHNLQMKAMKMEPGPVPNNDYWEDVLGHDKPTKNTNTGEAAKKPAAPQSSVRTAAQPNGTPISTEPERSRPSRGRKRNYDDNSFVGYGEGYADDDDESGFYSNSEGSGKKKRKKDHVSKIPAPPDRGGSYGVGMFGIDPYQKTLTLIDTAHSADPKQVTPPQAQSPIPYELLYADKMTKYLSLRSPSAPDALRLAVRAQHLRRWEVPRTDFPATKIGYHSWRSHLARRQAEIARGFCVEAGYDEPFAERVAALVRKEGLKSSGEDADVQVLEDVACLVFLEDQLEDFQSGYDEEKVIGILQRTWAKMSEKGRELALGMELSGKSKELVGRALADGSAA
Length649
PositionHead
OrganismAspergillus versicolor CBS 583.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.728
Instability index54.27
Isoelectric point5.94
Molecular weight70060.05
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11177
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     484.14|     155|     189|     148|     332|       1
---------------------------------------------------------------------------
  148-  220 (67.19/41.51)	.........................................................................................................................HDKNLESLQTGTGVRDFAQMGGSSQV...PHGDAMELD.TE.PSAHTN.SNWPS.LESLQKEFSSAFhlCksshIATGPD
  224-  390 (193.19/157.01)	DLISLYGLGpvaRSVARNDPVTGekinrlrksYEGKLKGLGLSGRNKP.VKHDPSTP..GGLRQMTMWPEEEWQnqkvfgKEIKVadMDSAlHNLQMKAM..KMEPGPVPNND.YwedvlgHDKPTKNTNTGEAAKKPAAPQSSVRTaaqPNG..TPIS.TE.P....E.RSRPS..RGRKRNY.................
  391-  554 (223.76/129.22)	DDNSFVGYG...EGYADDDDESG.........FYSNSEGSGKKKRKKDhVSKIPAPPdrGGSYGVGMFGIDPYQ......KTLTL..IDTA.HSADPKQVtpPQAQSPIPYELlY....adKMTKYLSLRSPSA.PDALRLAVRAQ.....HLRRWEVPrTDfPATKIGyHSWRShLARRQAEIARGF..C....VEAGYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.23|      30|      35|      17|      48|       2
---------------------------------------------------------------------------
    4-   35 (38.72/14.02)	...RTPSAPLRtgplsP.................SSPAPFTSPKDSLQPAIT
   38-   88 (39.81/17.04)	QVPQTPTSPPLmsvsaPnnasdfasmqalpnqatSQPASLSSPPSS.APMST
   89-  111 (36.70/10.65)	QTSQQPTSGIT.....N.................S....FPTPASSVDP...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11177 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKGLGLSGRNKPVKHDPSTPGGLRQMTMWPEEEWQ
2) MSDRTPSAPLRTGPLSPSSPAPFTSPKDSLQPAITLDQVPQTPTSPPLMSVSAPNNASDFASMQALPNQATSQPASLSSPPSSAPMSTQTSQQPTSGITNSFPTPASSVDPDHNDKSFGTGISEAGASAPAGASVVPTQQSEDRRADHDKNLESLQTGTGVRDFAQMGGSSQVPHGDAMELDTEPSAHTNSNWPSLES
3) SALHNLQMKAMKMEPGPVPNNDYWEDVLGHDKPTKNTNTGEAAKKPAAPQSSVRTAAQPNGTPISTEPERSRPSRGRKRNYDDNSFVGYGEGYADDDDESGFYSNSEGSGKKKRKKDHVSKIPAPPDRGGSYGVGM
260
1
310
294
198
445










Molecular Recognition Features






MoRF SequenceStartStop




1) PYELLY
2) WEDVL
479
333
484
337