<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11168

Description Uncharacterized protein
SequenceMIPHSSAGVQSWGHPLRKLDNGSGRVDASQAPSLSDFRSETQQSTPVLPPHTGQPAVIDLTSSINDAQEREPPAKRLRLDVSAGSSAKDASPAPATGGDSRVTPGIANAKPSSLSWRGRPVWSFQAMVSEATNGGEVMEDDAGLTPEGKKPASPPPFPPLPWKGAPPEQYGNNATKISESPTSKEVQTTPFRVQIPSIAPALKGDRIADFAPWTGDHPEDALNDQTVKQGYYDRTQVSQTESNTARPSLYAQLKHRSGLQMLSSVFMAALEKRQNHNTVNAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKALLDQCLSKLIPVSRAVWLAKCVGANEIRAFKRKGTSGSLAIGLEAKWVREWTSGVQQFLEGVVGACGSTGWKSKMTYAASLTARLFFERLLDHDQYFTWFLASLEASPLNMIPVWLLMLGIYWDSLLRYRKRGRRLAEVLLEKLRQITELRRPILLQPLADRLSSYIRKLVLEHTSSVILPNLWETHRNLILSCLKMKETADKTIFETLAERNTRVQLPKSRPESTEQSAQQRVVQLFDSIRSSHDISSTSTACLNALEDRVTLVAKLLEWSATRFRSGLRRVYTAARLLRKWKMSGIDIDTYIILFVSNVQDTSQLDMDNIYHVISELVRSQTFSISRYLQWLMAKGVARNAGGDNNEVLAGDTLLLTQLPLGRLPEHVRNLRYTLLARTGMSVTEESSTIQDLKLAISQRLPNIFQVKDSNKVFTELPQPNLTWAVKSEVSIWIRQGVAKHLRDTTRKIAGRPFSIDSKVSALIPEEFYCVREILEGFGDLSILADVIKQATECDDNTVLASASDTVNYHFDALSIIGATSDLFRGLVGAYARLKRFGTLNLDFTFSLIELGLRIPEESGTVSLLRQDLARIESKSALAAPSPLSDHIPTTFSDTDASFQEKLDQLLSCGNGIDESTLGSVFHSLTKILTFGSGTTKLSAKDACRYLAYLRPFSPKYFDIMLVRYVCGLLKSSSRPTMSRILAPLIGVGCVTIHSFVLLVNKLSAPENAVPAIPNMSSLRLDVLELLIPQSEPNTDLVTYRFHLAQQEFLVKYSDETLSIINDAIPLFDSLEDATLGTRRPDLQACTAKLLRSLLTQNSSSVAEYCMRELTGNSSFTTVLGKAVDLLLRFDSQDDVDPSAQAEQVILMNNDFSLPFCQLKLQLLFHANPGDEVKNNIVDVMFKAAVADSRSKKSHWVGLVNLMNQDAARQIRERAESGFFSVAMFDEPADDLISSDGAASTDAIDSAKLYLTIIEKLAHNIPEAGVPSVTPLLVERLDLLLQKLIIMQTNTNSFAENRNVSSSGPVVMARFNFERSLAFWFSALLRMTVLHRTAFNAPASHGHKAGSLQEQTRLLVSIFCISLARLPDNIIHLFPTANYFPHTVQPKNFRPCPGILLQTHALDVAASLIDSFPDEARLQCGRFLKEKCPPFLQFQNDHRFLYLLGPMADTTTHNSQLPASISSPAAGGSTPTPTPSGNASAGPSNQSQQVAASTGSVPGSSESTNSVADRLRIQHRGRIIGPYPVRPWELLEDAAPILGVNDTAVSLKLFDARRVRA
Length1596
PositionKinase
OrganismAspergillus versicolor CBS 583.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.188
Instability index49.37
Isoelectric point8.67
Molecular weight176156.02
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11168
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.95|      24|     317|     329|     352|       1
---------------------------------------------------------------------------
  329-  352 (45.40/29.63)	LD.....QCLSKLI.....PVSRAV.WL.AKCVGAN
  644-  679 (22.55/10.96)	LDmdniyHVISELVrsqtfSISRYLqWLmAKGVARN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     630.74|     212|     255|     846|    1073|       2
---------------------------------------------------------------------------
  846- 1073 (324.95/290.91)	VNYHFDALSIIGATSDLFRGLVGA............YARLKRfgTLNLDFTFSLIELGLR.IPEESGTVSLLRQ..D.LARIESKSALaAPSPLSDHIPTTFSDTDASF.QEKLdQLLSCGNGIDEsTLGSVFHSLTKILTFGS........GTTKLSAKDACRYLaYLRPFSpKYFDI.MLVRYVCGLLKSSSRPTMSRILAPLIgvgcvtihsFVLLVNKL..SAPENAVPAIPNMSSLRLDVL..ELLIPQSEPN
 1090- 1331 (305.80/225.22)	VKYSDETLSIINDAIPLFDSLEDAtlgtrrpdlqacTAKLLR..SLLTQNSSSVAEYCMReLTGNSSFTTVLGKavDlLLRFDSQDDV.DPSAQAEQVILMNNDFSLPFcQLKL.QLLFHANPGDE.VKNNIVDVMFKAAVADSrskkshwvGLVNLMNQDAARQI.RERAES.GFFSVaMFDEPADDLISSDGAASTDAIDSAKL.........YLTIIEKLahNIPEAGVPSVTPLLVERLDLLlqKLIIMQTNTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.15|      23|     314|      99|     122|       3
---------------------------------------------------------------------------
   99-  122 (39.33/24.46)	DSRVTPgIANAKP.SSLSWRGRPVW
  146-  166 (32.67/15.15)	PEGKKP..ASPPPfPPLPWKGAP..
  428-  442 (21.16/ 6.81)	.......LASLEA.SPLNM..IPVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.10|      29|     701|     682|     710|       6
---------------------------------------------------------------------------
  682-  710 (49.69/30.35)	GDNNEVLAGDTLLLTQ...LPLGRLPEHVRNL
 1381- 1412 (43.41/25.57)	GHKAGSLQEQTRLLVSifcISLARLPDNIIHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.03|      65|    1434|      24|      97|      10
---------------------------------------------------------------------------
   24-   97 (96.62/78.40)	GRVDASQAPSLSDFRSEtQQSTPVLPP......H.tgqPAVIDLTSSINDAQEREPPAkrlrlDVSAGSSAKDASPAPATG
 1460- 1534 (106.41/63.59)	GRFLKEKCPPFLQFQND.HRFLYLLGPmadtttHnsqlPASISSPAAGGSTPTPTPSG.....NASAGPSNQSQQVAASTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11168 with Med12 domain of Kingdom Fungi
Unable to open file!