<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11163

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGGSITNIRVIDGFSNVYWRIYTEDTSSTHPASDGPSNGRTVLKHISRLKELELRLRSQGSLVLSYPRRLGLLIFSATPDFEHLSPTLLSERGDDSSRLLVGSTILKVWTSGSVSSGDLAKSHRSDFQTASANSPAPSQRLQGSSVQPRRVDNSGGSAAIYASFISAVTAAFSLQIVRQNNAIPLGPRTLFNTVESDLNEGQGAVNDEPSSVPALTTLQAQLTSVGKLTIAFQTVVQTGLTRLNKPGENSLEAAPGTDLWLAPTGSIARLVAAHPEDINNKLSFSASEDAGQWKQNVLEWLGYFGLPIDAVTGEGWVEVEVWEPFYSKLSGEARVKQEGHSLPLKRILWPAAYCFRRTKSTQLEAPEKTEVNPPFFCDPLDFAEDWYTKEIPKTAETDLELPSEGPERQISNQDTLSPGFASLPEGIESLSRASLYPEMQSASLVYPTPPDGTAGVGVNPTNIRSTSKSGVDPDVTMEFGPAAGLGVGSGLYDTNEDDDLFGDMNERDFGTKGITDADFSFFDDDGFDHPGKGSNIGHRQESPDFVDPAKPSAVVELSEPIAPSPNSAPIDVKGVTEESPEQTHDLPRHDPIPESNAPMSSPHYGQMQTISPPLSPVEVKRILFPDSSSSNQLVAKSTHVPSHYSPVAFKNNGSSWDQKYGADGKFSFVGPGTAFTQDPYTSTEGIPTIGLPRRKSNVKALTLPKAPGGDEPAPNEMESSSPDSSSETGESDNDGLESNILPTTLATLKRKRARSSPGNSPIISSDKALNGLQGISKSEDSVFLGNFLSTFSDWSIAGFFSLSENQVFPSLAPQEAQVQVAQILVDQITQSSLDHKLDGEFGVSCLDNQAFSHRELLAVSEYLGSFDRLDLNAFVSLEEQIPFSPDASSGLTPRKNSQRKEPGKGSITRLPLPHLRVRRGKSFLETLPPAISFWETFDLEPAHGPKDITAYCIHPHIMTRAADTFLERLGLLYTSCNLGSHSRGDCSGSFSNGLAEWAVNPSKRTNYPSMMLQLKGICGDLAGTALLESPPSKENIIIYIINPFSHAASLVDICAAFWCLLQTYFANEDKQQSKPLNEVLLQVIPMDFVMSAESLVVPPQTDYLNLAMEVYSRCSTGQIQSSLMDCAPPVMLAETLPQSIGFKLASESSPPMQEGKCLHVACSRSRDQRWMSVAWSDNSGALQRTMSYCIRFRNSTTSRALPAVRSEIWAATKDIMDKSQARWRVILVNTENVDQDEHDTWLGLAEQYNKSRPVPVELTILSVNTAADLSLSPPRSPMPMSVLNPQTSSTPIATPLPSGSILSPDQVGNAPTPPSGANAPANAPTPTDPLFESEPESLLTDICDESWSVVLSHRLNGTLHLTEYRPALASGYLLRRKGPTDADGAFSMNVNLLFTQRSSYSHENTLREIIGLYRDLATLARIRGTRIVQTGTLPWHIATAVRAQEILSYVL
Length1454
PositionKinase
OrganismAspergillus versicolor CBS 583.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.341
Instability index52.81
Isoelectric point5.03
Molecular weight157906.88
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11163
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     359.28|      80|     203|     928|    1007|       1
---------------------------------------------------------------------------
  928- 1007 (141.61/89.13)	ETLPPAISFW....ETFDLEPAHGPKDITAYCIH..PHIMTRAADTFLERLGLLYTSCNLGSHSR..GDCS.GSFSNGLAEWAVNPSKR
 1055- 1136 (105.41/64.25)	DI...CAAFWcllqTYFANEDKQQSKPLNEVLLQviPMDFVMSAESLVVPPQTDYLNLAMEVYSR....CStGQIQSSLMDCAPPVMLA
 1137- 1208 (112.26/68.95)	ETLPQSIG........FKLASESSPPMQEGKCLH..V.ACSRSRD...QRWMSVAWSDNSGALQRtmSYCI..RFRNSTTSRAL.PAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.89|      16|      16|    1273|    1288|       2
---------------------------------------------------------------------------
  612-  628 (22.16/ 7.34)	TISPPLSPVEV.KrILFP
 1273- 1288 (31.99/13.90)	SLSPPRSPMPM.S.VLNP
 1291- 1307 (24.73/ 9.06)	SSTPIATPLPSgS.ILSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.41|      20|      20|     528|     547|       3
---------------------------------------------------------------------------
  528-  547 (36.70/19.68)	DGF..DHPGKGSNIGHRQESPD
  576-  597 (26.71/12.12)	KGVteESPEQTHDLPRHDPIPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.86|      16|      42|     796|     811|       5
---------------------------------------------------------------------------
  796-  811 (30.57/18.72)	DWSIAGFFSLS..ENQVF
  837-  854 (25.29/14.17)	DHKLDGEFGVSclDNQAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.88|      37|      43|      74|     115|       6
---------------------------------------------------------------------------
   74-  115 (55.37/42.64)	GLLIFSATPDFEHLSptllSERGDDSSRLLvGSTIL..KVWTSG
  120-  158 (60.51/33.25)	GDLAKSHRSDFQTAS....ANSPAPSQRLQ.GSSVQprRVDNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.72|      18|      20|     407|     426|       7
---------------------------------------------------------------------------
  407-  426 (24.61/20.90)	EGPErQISnQDTLSPGF..ASL
  428-  447 (27.11/13.21)	EGIE.SLS.RASLYPEMqsASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.60|      66|     863|     450|     524|       8
---------------------------------------------------------------------------
  450-  524 (102.99/79.61)	PTPPDGtAGVGVN...PTNirstsKSGVDPDVTMeFGPaaGLGVGSGLYDTNEDDDLFGDMNE...............................RDFGTKGITDADFSF
  662-  705 (58.22/27.10)	........................KYGADGKFSF.VGP..GTAFTQDPYTSTEGIPTIG.LPR...............................RKSNVKALT......
 1314- 1389 (57.39/28.12)	PTPPSG.ANAPANaptPTD...........................PLFES.EPESLLTDICDeswsvvlshrlngtlhlteyrpalasgyllrR....KGPTDADGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.74|      54|     859|       6|      65|       9
---------------------------------------------------------------------------
    6-   65 (85.24/61.50)	GSITNIRvIDGFSNVYWRI.YTEDTSST.HPASDG....PSNGrtvlkHISRLKELELRLRSQGSL
  867-  926 (80.50/45.13)	GSFDRLD.LNAFVSLEEQIpFSPDASSGlTPRKNSqrkePGKG.....SITRLPLPHLRVRRGKSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      12|      22|     346|     357|      12
---------------------------------------------------------------------------
  346-  357 (24.34/13.54)	PLKRILWPAAYC
  369-  380 (24.47/13.65)	PEKTEVNPPFFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.98|      60|     532|     190|     253|      13
---------------------------------------------------------------------------
  190-  253 (82.87/58.66)	PRTLFNTVESDlNEGQGAvNDEPSSVPALTTLQAQlTSVGKLTIAFQTVVQTGLTRLNKpGENS
  725-  784 (100.11/54.04)	PDSSSETGESD.NDGLES.NILPTTLATLKRKRAR.SSPGNSPIISSDKALNGLQGISK.SEDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11163 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKSHRSDFQTASANSPAPSQRLQGSSVQPR
2) FSFFDDDGFDHPGKGSNIGHRQESPDFVDPAKPSAVVELSEPIAPSPNSAPIDVKGVTEESPEQTHDLPRHDPIPESNAPMSSPHYGQMQTISP
3) KTAETDLELPSEGPERQISNQDTLSPGFASL
4) LSLSPPRSPMPMSVLNPQTSSTPIATPLPSGSILSPDQVGNAPTPPSGANAPANAPTPTDPLFESEP
5) MQSASLVYPTPPDGTAGVGVNPTNIRSTSKSGVDPDVTMEFGPAAGLGVGSGLYDTNEDDDLFGDMNERDF
6) SFVGPGTAFTQDPYTSTEGIPTIGLPRRKSNVKALTLPKAPGGDEPAPNEMESSSPDSSSETGESDNDGLESNILPT
7) SPVEVKRILFPDSSSSNQLVAKSTHVPSHYSPVAFKNNGSSW
123
522
396
1272
442
670
618
152
615
426
1338
512
746
659










Molecular Recognition Features






MoRF SequenceStartStop




1) VKRILFP
622
628